scholarly journals Estimation of the Contribution of Non–Assisted Reproductive Technology Ovulation Stimulation Fertility Treatments to US Singleton and Multiple Births

2009 ◽  
Vol 170 (11) ◽  
pp. 1396-1407 ◽  
Author(s):  
Laura A. Schieve ◽  
Owen Devine ◽  
Coleen A. Boyle ◽  
Joann R. Petrini ◽  
Lee Warner
Keyword(s):  
Assisted Reproductive Technology ◽  
Reproductive Technology ◽  
Multiple Births ◽  
Fertility Treatments ◽  
Ovulation Stimulation

Estimation of the Contribution of Assisted and Non-Assisted Reproductive Technology Fertility Treatments to Multiple Births During the Past 30 Years in Japan: 1979–2008

2011 ◽  
Vol 14 (5) ◽  
pp. 476-483 ◽  
Author(s):  
Syuichi Ooki
Keyword(s):  
Assisted Reproductive Technology ◽  
Social Impact ◽  
Vital Statistics ◽  
Reproductive Technology ◽  
Multiple Births ◽  
Fertility Treatment ◽  
Approximation Formula ◽  
Multiple Birth ◽  
Fertility Treatments ◽  
Ovulation Stimulation

The effect of assisted reproductive technology (ART) and non-ART ovulation stimulation fertility treatment on the number and rate of multiple live births from 1979–2008 in Japan was estimated using two independent data sources, ART statistics and vital statistics. Japanese ART statistics presented by the Japan Society of Obstetrics and Gynecology between 1989 and 2008 were gathered and reanalyzed. The number and rates of ART between 1984 and 1988 were interpolated using an approximation formula, using the values from 1983, when the first ART baby was born in Japan, and the 1989–1992 values. The number of ART multiples between 1979–1982 was set as equal to zero. The minimum (or maximum) number of non-ART iatrogenic multiple births was estimated by subtracting the maximum (or minimum) ART multiples from the total iatrogenic multiples, which was estimated by vital statistics assuming that spontaneous multiple-birth rates according to maternal age class would be constant. There was an overall increase in the non-ART multiple births during the 30-year period, whereas ART multiples tended to increase from 1983 to 2005, and then rapidly decreased thereafter. The number or percentage of ART multiples was almost consistently lower than that of non-ART multiples. The percentage of non-ART multiples (33%) among the total multiples was estimated to be about three times more than the ART multiples (11–12%) in 2008. Given the medical and social impact of multiple births, it is imperative to construct a hospital-based monitoring system for fertility treatments, specially non-ART fertility treatments and multiple births.

Trends in Multiple Births Conceived Using Assisted Reproductive Technology, United States, 1997–2000

PEDIATRICS ◽  
2003 ◽  
Vol 111 (Supplement_1) ◽  
pp. 1159-1162 ◽  
Author(s):  
Meredith A. Reynolds ◽  
Laura A. Schieve ◽  
Joyce A. Martin ◽  
Gary Jeng ◽  
Maurizio Macaluso
Keyword(s):  
United States ◽  
Assisted Reproductive Technology ◽  
The United States ◽  
Population Based ◽  
Reproductive Technology ◽  
Multiple Births ◽  
Multiple Gestation ◽  
Birth Rates ◽  
Live Births ◽  
Natural Conception

Objective. To examine trends in multiple births conceived using assisted reproductive technology (ART) in the United States between 1997 and 2000 and to estimate the proportion of all US multiple births attributable to ART use. Methods. We analyzed population-based data of 109 519 live-born infants who were conceived in the United States using ART and born between 1997 and 2000 and population-based data of 15 856 809 live-born infants who were delivered in the United States between 1997 and 2000. Multiple birth rates (the number of live-born infants delivered in multiple gestation pregnancies per 1000 live births) and the proportion of all US multiple births attributable to ART were evaluated. Results. The twin rate for ART patients increased between 1997 and 2000, reaching 444.7 per 1000 live births in 2000, whereas the triplet/+ rate declined substantially from 134.3 to 98.7 per 1000 live births from 1997–2000. From 1997–2000, the proportion of multiple births in the United States attributable to ART increased from 11.2% to 13.6%, whereas the proportion attributable to natural conception decreased from 69.9% to 64.5%. In 2000, the proportion of triplet/+ births attributable to ART and to natural conception was 42.5% and 17.7%, respectively. The contribution of ART to multiple births increased substantially with maternal age, from 11.6% for triplet/+ infants born to women aged 20 to 24 to 92.8% for women aged 45 to 49 years. Conclusions. The contribution of ART to twin birth rates continues to increase, but the contribution of ART to triplet/+ birth rates has declined.

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