Spina bifida before and after folic acid fortification in Canada

2008 ◽  
Vol 82 (9) ◽  
pp. 622-626 ◽  
Author(s):  
Philippe De Wals ◽  
Fassiatou Tairou ◽  
Margot I. Van Allen ◽  
R. Brian Lowry ◽  
Jane A. Evans ◽  
...  
Keyword(s):  
Folic Acid ◽  
Spina Bifida ◽  
Folic Acid Fortification ◽  
Before And After

Prevalence of spina bifida and anencephaly during the transition to mandatory folic acid fortification in the United States

Teratology ◽  
2002 ◽  
Vol 66 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Laura J. Williams ◽  
Cara T. Mai ◽  
Larry D. Edmonds ◽  
Gary M. Shaw ◽  
Russell S. Kirby ◽  
...  
Keyword(s):  
United States ◽  
Folic Acid ◽  
Spina Bifida ◽  
The United States ◽  
Folic Acid Fortification

Effects of folic acid fortification on spina bifida prevalence in Brazil

2011 ◽  
Vol 91 (9) ◽  
pp. 831-835 ◽  
Author(s):  
Iêda Maria Orioli ◽  
Ricardo Lima do Nascimento ◽  
Jorge Santiago López-Camelo ◽  
Eduardo Enrique Castilla
Keyword(s):  
Folic Acid ◽  
Spina Bifida ◽  
Folic Acid Fortification

scholarly journals Serum homocysteine and folate concentrations among a US cohort of adolescents before and after folic acid fortification

2012 ◽  
Vol 15 (10) ◽  
pp. 1818-1826 ◽  
Author(s):  
Daniel A Enquobahrie ◽  
Henry A Feldman ◽  
Deanna H Hoelscher ◽  
Lyn M Steffen ◽  
Larry S Webber ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cardiovascular Health ◽  
Serum Folate ◽  
Vitamin B ◽  
Serum Concentrations ◽  
Folic Acid Fortification ◽  
Serum Homocysteine ◽  
Cereal Grain ◽  
Before And After ◽  
Average Serum

AbstractObjectiveWe assessed serum homocysteine (tHcy) and folate concentrations among US adolescents before and after fortification of cereal-grain products with folic acid, and associations with demographic, behavioural and physiological factors.DesignObservational study conducted among participants of a randomized trial.SettingThe Child and Adolescent Trial for Cardiovascular Health (CATCH) study.SubjectsAdolescents (n2445) in grades 8 (pre-fortification, mean age 14 years) and 12 (post-fortification, mean age 18 years).ResultsAverage serum concentrations of tHcy, folate and vitamin B6increased by 17 %, 16 % and 14 %, respectively, while serum concentrations of vitamin B12decreased by 11 % post-fortification. Folic acid fortification provided, on average, an additional intake of 118 μg folate/d. Male sex (P< 0·0001) and white race (P= 0·0008) were associated with significantly greater increases in tHcy concentration, while increases in BMI (P= 0·006) and serum folate concentration (P< 0·0001) were associated with significant decreases in tHcy concentration. Female sex (P< 0·0001), non-smoking (P< 0·0001), use of multivitamins (P< 0·0001) and higher dietary intake of folate (P= 0·001) were associated with significantly greater increases in serum folate concentrations. From grade 8 to grade 12, the upward age trend in serum tHcy concentration was uninterrupted in its course (P> 0·50); whereas serum folic acid concentration showed a downward trend that incurred a discrete jump upward (17 % higher;P< 0·0001) with fortification. These trends differed significantly for malesv. females (P< 0·001 for interaction).ConclusionsFortification had a significant impact on improving folate status but not serum tHcy concentrations among US adolescents.

Prevalence of Spina Bifida and Anencephaly During the Transition to Mandatory Folic Acid Fortification in the United States

2003 ◽  
Vol 58 (2) ◽  
pp. 90-92
Author(s):  
Laura J. Williams ◽  
Cara T. Mai ◽  
Larry D. Edmonds ◽  
Gary M. Shaw ◽  
Russell S. Kirby ◽  
...  
Keyword(s):  
United States ◽  
Folic Acid ◽  
Spina Bifida ◽  
The United States ◽  
Folic Acid Fortification

scholarly journals The mortality rate after hospital discharge in patients with myelomeningocele decreased after implementation of mandatory flour fortification with folic acid

2017 ◽  
Vol 75 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Renato Manganelli Salomão ◽  
Tatiana Protzenko Cervante ◽  
José Francisco Manganelli Salomão ◽  
Soniza Vieira Alves Leon
Keyword(s):  
Folic Acid ◽  
Hospital Discharge ◽  
Cause Of Death ◽  
Chiari Ii Malformation ◽  
Folic Acid Fortification ◽  
Significant Difference ◽  
Before And After ◽  
Reference Hospital ◽  
The Central Nervous System ◽  
Chiari Ii

ABSTRACT Objective: To evaluate the mandatory folic acid fortification of flour on mortality rates after the hospital discharge of children born with myelomeningocele, the most affected age group and the most frequent cause of death. Methods: A retrospective study of 383 children born with myelomeningocele from January 1990 to December 2013 in a high-fetal-risk reference hospital. Results: A total of 39 patients died (10.1%),of which 23 (6%) died after discharge. Most children who died were younger than 12 months of age. The most frequent cause of death was infection of the central nervous system, followed by urinary tract sepsis and infections of the respiratory system. Symptomatic Chiari II malformation was the most frequent comorbidity factor. Conclusion: Although there was no significant difference in infant mortality before and after folic acid fortification, there was a significant reduction in deaths after hospital discharge in babies born after implementation of mandatory folic acid fortification

Sign in / Sign up

Export Citation Format

Share Document