Analysis of polymorphisms of genes associated with folate-mediated one-carbon metabolism and neural tube defects in Chinese Han Population

2016 ◽  
Vol 106 (4) ◽  
pp. 232-239 ◽  
Author(s):  
Wei Piao ◽  
Jin Guo ◽  
Yihua Bao ◽  
Fang Wang ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Carbon Metabolism ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
One Carbon Metabolism

Association Study of PARD3 Gene Polymorphisms With Neural Tube Defects in a Chinese Han Population

2012 ◽  
Vol 19 (7) ◽  
pp. 764-771 ◽  
Author(s):  
Yonghui Gao ◽  
Xiaoli Chen ◽  
Shaofang Shangguan ◽  
Yihua Bao ◽  
Xiaoli Lu ◽  
...  
Keyword(s):  
Association Study ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Association between ALDH1L1 gene polymorphism and neural tube defects in the Chinese Han population

2016 ◽  
Vol 37 (7) ◽  
pp. 1049-1054 ◽  
Author(s):  
Lihua Wu ◽  
Xiaolin Lu ◽  
Jin Guo ◽  
Ting Zhang ◽  
Fang Wang ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Novel Mutation of LRP6 Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects

2017 ◽  
Vol 110 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Zhiwen Shi ◽  
Xueyan Yang ◽  
Bin-Bin Li ◽  
Shuxia Chen ◽  
Luming Yang ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Novel Mutation ◽  
Chinese Han Population ◽  
Canonical Wnt Signaling ◽  
Chinese Han ◽  
Han Population ◽  
Canonical Wnt

scholarly journals Neural tube defects and maternal intake of micronutrients related to one-carbon metabolism or antioxidant activity

2012 ◽  
Vol 94 (11) ◽  
pp. 864-874 ◽  
Author(s):  
Angela L. Chandler ◽  
Charlotte A. Hobbs ◽  
Bridget S. Mosley ◽  
Robert J. Berry ◽  
Mark A. Canfield ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Carbon Metabolism ◽  
One Carbon Metabolism

One-carbon metabolism in pregnancies complicated by neural tube defects

The Lancet ◽  
1995 ◽  
Vol 345 (8952) ◽  
pp. 791 ◽  
Author(s):  
Nozar Habibzadeh ◽  
Jennifer Wild ◽  
MarkD. Lucock ◽  
ChristopherJ. Schorah
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Carbon Metabolism ◽  
One Carbon Metabolism

Neural tube defects and disturbed maternal folate- and homocysteine-mediated one-carbon metabolism

2008 ◽  
Vol 212 (2) ◽  
pp. 515-521 ◽  
Author(s):  
Hong-Yang Zhang ◽  
Guo-An Luo ◽  
Qiong-Lin Liang ◽  
Yong Wang ◽  
Hui-Hua Yang ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Carbon Metabolism ◽  
One Carbon Metabolism

scholarly journals Balanced Essential Micronutrients during Pregnancy: High Concern

2018 ◽  
Vol 4 (2) ◽  
pp. 259-261
Author(s):  
Srilatha Bashetti ◽  
Kumar SaiSailesh ◽  
Aparna Varma ◽  
Rajagopalan Vijayaraghavan
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Carbon Metabolism ◽  
Strong Predictor ◽  
Fetal Loss ◽  
Folate Deficiency ◽  
Cobalamin Deficiency ◽  
One Carbon Metabolism

Nutrition and epigenetic changes is the emerging topic of interest in the present scenario to understand the effects of increased supplementation of micronutrients like Folic Acid (FA). The study is taken up in the public health interest, to evaluate the importance of balancing the different micronutrients in the diet to avoid unbalanced nutritional disorders and other health complications later in life. It has been hypothesized that disease risks after birth or later in life can be determined by paternal or maternal diet. This raised an interest to study in-utero effects of environmental exposures like air pollution, toxins, nutrition, etc. It had been assumed that during embryonic period most of the dividing tissues get exposed to the environmental insults and that change results in predisposition of cancer or other health outcomes. There could be the possibility of maternal exposures like nutrition may alter the intrauterine one-carbon metabolism or the precursor milieu and may be involved in the disruption of one-carbon metabolism in developing offspring. Modification in methyl me of offspring with subsequent changes in phenotypes has been noted in the preliminary studies with increased folic acid (FA) supplementation during pregnancy. Maternal folate deficiency has been implicated as a cause of prematurity and both folate deficiency and cobalamin deficiency have been implicated in recurrent fetal loss and neural tube defects. Folic acid supplementation at the time of conception and in the first 12 weeks of pregnancy is expected to reduce by 70% the incidence of neural tube defects (NTDs) (meningomyelocele, encephalocele and spina bifida) in the fetus. Most of the protective effect can be achieved by taking folic acid, 0.4 mg daily at the time of conception. However there is no clear relationship between maternal folatestatus and the fetal abnormalities. It has been observed that, the lower the maternal folate, the greater the risk to the fetus. On the other hand maternal cobalamin status is a strong predictor of vitamin B12 in breastfed infants up to at least 6 months of age. Because of the transfer from mother to offspring during pregnancy and lactation, maternal requirements during this period are increased and deficiency may occur. The influence of low vitamin B12 during pregnancy may have cognitive ability of children later in life. Hypothyroidism is caused by insufficient production of thyroid hormones by the thyroid gland. In females, hypothyroidism is associated mainly with oligomenorrhea.

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