scholarly journals Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints

2012 ◽  
Vol 64 (10) ◽  
pp. 3267-3277 ◽  
Author(s):  
Lin-Hsiu Weng ◽  
Jih-Yang Ko ◽  
Ching-Jen Wang ◽  
Yi-Chih Sun ◽  
Feng-Sheng Wang
Keyword(s):  
Synovial Fibroblasts ◽  
Cartilage Matrix ◽  
And Cartilage

scholarly journals Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yan Zhou ◽  
Jianghua Ming ◽  
Yaming Li ◽  
Bochun Li ◽  
Ming Deng ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Apoptotic Cell ◽  
Synovial Fibroblasts ◽  
Cartilage Degeneration ◽  
Cartilage Degradation ◽  
Exosomal Mirnas ◽  
Exosomal Mirna ◽  
And Control ◽  
And Cartilage

AbstractMicroRNAs (miRNAs) encapsulated within exosomes can serve as essential regulators of intercellular communication and represent promising biomarkers of several aging-associated disorders. However, the relationship between exosomal miRNAs and osteoarthritis (OA)-related chondrocytes and synovial fibroblasts (SFCs) remain to be clarified. Herein, we profiled synovial fluid-derived exosomal miRNAs and explored the effects of exosomal miRNAs derived from SFCs on chondrocyte inflammation, proliferation, and survival, and further assessed their impact on cartilage degeneration in a surgically-induced rat OA model. We identified 19 miRNAs within synovial fluid-derived exosomes that were differentially expressed when comparing OA and control patients. We then employed a microarray-based approach to confirm that exosomal miRNA-126-3p expression was significantly reduced in OA patient-derived synovial fluid exosomes. At a functional level, miRNA-126-3p mimic treatment was sufficient to promote rat chondrocyte migration and proliferation while also suppressing apoptosis and IL-1β, IL-6, and TNF-α expression. SFC-miRNA-126-3p-Exos were able to suppress apoptotic cell death and associated inflammation in chondrocytes. Our in vivo results revealed that rat SFC-derived exosomal miRNA-126-3p was sufficient to suppress the formation of osteophytes, prevent cartilage degeneration, and exert anti-apoptotic and anti-inflammatory effects on articular cartilage. Overall, our findings indicate that SFC exosome‐delivered miRNA-126-3p can constrain chondrocyte inflammation and cartilage degeneration. As such, SFC-miRNA-126-3p-Exos may be of therapeutic value for the treatment of patients suffering from OA.

MORQUIO'S DISEASE

PEDIATRICS ◽  
1964 ◽  
Vol 34 (6) ◽  
pp. 839-850 ◽  
Author(s):  
Eric A. Schenk ◽  
James Haggerty
Keyword(s):  
Patent Ductus Arteriosus ◽  
Clinical Features ◽  
Ductus Arteriosus ◽  
Foam Cells ◽  
Cartilage Matrix ◽  
Abnormal Accumulation ◽  
The Matrix ◽  
And Cartilage ◽  
Morphologic Changes ◽  
Patent Ductus

The radiologic and morphologic changes seen in a patient with Morquio's disease who came to autopsy are described and discussed. Pathologic changes were limited to cartilage and consisted of cytochemically definable lesions of the matrix characterized by the presence of amorphous and fibrillar lesions and the accumulation of foam cells. An abnormal accumulation of mucopolysaccharides in foam cells and cartilage matrix was present. No evidence of visceral storage of mucopolysaccharides, such as is seen in Hurler's disease, was present. In addition to Morquio's disease, this patient had a patent ductus arteriosus. Clinical features and radiologic changes in an older living sibling, who has had Morquio's disease and is now apparently developing the Morquio-Ullrich variant, are described.

scholarly journals Impact of Hypothermia upon Chondrocyte Viability and Cartilage Matrix Permeability after 1 Month of Refrigerated Storage

2011 ◽  
Vol 38 (6) ◽  
pp. 387-392 ◽  
Author(s):  
Kelvin G.M. Brockbank ◽  
Eliza Rahn ◽  
Gregory J. Wright ◽  
Zhenzhen Chen ◽  
Hai Yao
Keyword(s):  
Cartilage Matrix ◽  
Refrigerated Storage ◽  
Chondrocyte Viability ◽  
Matrix Permeability ◽  
And Cartilage

scholarly journals 221 COLLAGEN TYPE IX AND CARTILAGE OLIGOMERIC MATRIX PROTEIN INFLUENCE CARTILAGE MATRIX ASSEMBLY

2008 ◽  
Vol 16 ◽  
pp. S104
Author(s):  
Y.M. Bastiaansen-Jenniskens ◽  
K. Blumbach ◽  
W. Koevoet ◽  
M. Paulsson ◽  
J. DeGroot ◽  
...  
Keyword(s):  
Cartilage Oligomeric Matrix Protein ◽  
Matrix Protein ◽  
Collagen Type ◽  
Cartilage Matrix ◽  
Matrix Assembly ◽  
And Cartilage
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