scholarly journals Dietary weight loss and exercise for obese adults with knee osteoarthritis: Modest weight loss targets, mild exercise, modest effects

2004 ◽  
Vol 50 (5) ◽  
pp. 1366-1369 ◽  
Author(s):  
Marlene Fransen
Keyword(s):  
Weight Loss ◽  
Knee Osteoarthritis ◽  
Obese Adults ◽  
Modest Weight Loss ◽  
Dietary Weight Loss

Effects of dietary weight loss with and without exercise on fibrosis biomarkers in adults with knee osteoarthritis

2021 ◽  
Vol 29 ◽  
pp. S157-S158
Author(s):  
A.-C. Bay-Jensen ◽  
R. Loeser ◽  
P. Frederiksen ◽  
D. Beaver ◽  
M.A. Karsdal ◽  
...  
Keyword(s):  
Weight Loss ◽  
Knee Osteoarthritis ◽  
Dietary Weight Loss

scholarly journals Change in Physical Activity and Sedentary Time Associated With 2-Year Weight Loss in Obese Adults With Osteoarthritis

2016 ◽  
Vol 13 (5) ◽  
pp. 461-466 ◽  
Author(s):  
Christine A. Pellegrini ◽  
Jing Song ◽  
Rowland W. Chang ◽  
Pamela A. Semanik ◽  
Jungwha Lee ◽  
...  
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Knee Osteoarthritis ◽  
Weight Change ◽  
Sedentary Time ◽  
Vigorous Physical Activity ◽  
Elevated Risk ◽  
Obese Adults ◽  
Strong Trend ◽  
Light Activity

Background:We examined if changes in moderate-to-vigorous physical activity (MVPA), light activity, and sedentary behavior are related to weight change over a 2-year period in obese adults with/elevated risk for knee osteoarthritis.Methods:Weight, physical activity, and sedentary time at baseline and 2 years were obtained from 459 obese participants from the Osteoarthritis Initiative. Weight change was categorized as ≥ 10 lbs, 5.0 to 9.9 lbs, 4.9 to –4.9 lbs, –5.0 to –9.9 lbs, and ≤ –10 lbs. We examined the association between 2-year weight change categories and changes in activity/sedentary time from accelerometer monitoring by multiple linear regression adjusted for baseline weight, demographic, and health factors.Results:Across the 5 weight categories (loss to gain), average 2-year change ranged from -7.4 to 28.0 sedentary minutes/day, 4.2 to –23.1 light activity minutes/day, and 3.2 to –4.9 MVPA minutes/day, respectively. Higher weight loss categories were separately associated with increased MVPA (P for trend < 0.001) and less sedentary gain (P for trend = 0.01). Weight loss categories had a strong trend with light activity gain but not statistically significant (P for trend = 0.06).Conclusions:Small increases in MVPA and decreases in sedentary time over 2 years were associated with weight loss among adults with obesity and with or at elevated risk for knee osteoarthritis.

scholarly journals Changes in Plasma Short-Chain Fatty Acid Levels after Dietary Weight Loss among Overweight and Obese Adults over 50 Weeks

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 452
Author(s):  
Solomon A. Sowah ◽  
Frank Hirche ◽  
Alessio Milanese ◽  
Theron S. Johnson ◽  
Mirja Grafetstätter ◽  
...  
Keyword(s):  
Weight Loss ◽  
Calorie Restriction ◽  
Energy Homeostasis ◽  
Dietary Intervention ◽  
Short Chain Fatty Acids ◽  
Initial Study ◽  
Short Chain ◽  
Metabolic Effects ◽  
Obese Adults ◽  
Dietary Weight Loss

Gut microbial-derived short-chain fatty acids (SCFAs) may regulate energy homeostasis and exert anti-carcinogenic, immunomodulatory and anti-inflammatory effects. Smaller trials indicate that dietary weight loss may lead to decreased SCFA production, but findings have been inconclusive. SCFA concentrations were measured by HPLC-MS/MS in plasma samples of 150 overweight or obese adults in a trial initially designed to evaluate the metabolic effects of intermittent (ICR) versus continuous (CCR) calorie restriction (NCT02449148). For the present post hoc analyses, participants were classified by quartiles of weight loss, irrespective of the dietary intervention. Linear mixed models were used to analyze weight-loss-induced changes in SCFA concentrations after 12, 24 and 50 weeks. There were no differential changes in SCFA levels across the initial study arms (ICR versus CCR versus control) after 12 weeks, but acetate concentrations significantly decreased with overall weight loss (mean log-relative change of −0.7 ± 1.8 in the lowest quartile versus. −7.6 ± 2 in the highest, p = 0.026). Concentrations of propionate, butyrate and other SCFAs did not change throughout the study. Our results show that weight-loss, achieved through calorie restriction, may lead to smaller initial decreases in plasma acetate, while plasma SCFAs generally remain remarkably stable over time.

Sign in / Sign up

Export Citation Format

Share Document