A precision medicine approach to develop and internally validate optimal exercise and weight loss treatments for overweight and obese adults with knee osteoarthritis

2020 ◽  
Author(s):  
Xiaotong Jiang ◽  
Amanda E. Nelson ◽  
Rebecca J. Cleveland ◽  
Daniel P. Beavers ◽  
Todd A. Schwartz ◽  
...  
Keyword(s):  
Weight Loss ◽  
Knee Osteoarthritis ◽  
Precision Medicine ◽  
Obese Adults ◽  
Weight Loss Treatments

scholarly journals Change in Physical Activity and Sedentary Time Associated With 2-Year Weight Loss in Obese Adults With Osteoarthritis

2016 ◽  
Vol 13 (5) ◽  
pp. 461-466 ◽  
Author(s):  
Christine A. Pellegrini ◽  
Jing Song ◽  
Rowland W. Chang ◽  
Pamela A. Semanik ◽  
Jungwha Lee ◽  
...  
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Knee Osteoarthritis ◽  
Weight Change ◽  
Sedentary Time ◽  
Vigorous Physical Activity ◽  
Elevated Risk ◽  
Obese Adults ◽  
Strong Trend ◽  
Light Activity

Background:We examined if changes in moderate-to-vigorous physical activity (MVPA), light activity, and sedentary behavior are related to weight change over a 2-year period in obese adults with/elevated risk for knee osteoarthritis.Methods:Weight, physical activity, and sedentary time at baseline and 2 years were obtained from 459 obese participants from the Osteoarthritis Initiative. Weight change was categorized as ≥ 10 lbs, 5.0 to 9.9 lbs, 4.9 to –4.9 lbs, –5.0 to –9.9 lbs, and ≤ –10 lbs. We examined the association between 2-year weight change categories and changes in activity/sedentary time from accelerometer monitoring by multiple linear regression adjusted for baseline weight, demographic, and health factors.Results:Across the 5 weight categories (loss to gain), average 2-year change ranged from -7.4 to 28.0 sedentary minutes/day, 4.2 to –23.1 light activity minutes/day, and 3.2 to –4.9 MVPA minutes/day, respectively. Higher weight loss categories were separately associated with increased MVPA (P for trend < 0.001) and less sedentary gain (P for trend = 0.01). Weight loss categories had a strong trend with light activity gain but not statistically significant (P for trend = 0.06).Conclusions:Small increases in MVPA and decreases in sedentary time over 2 years were associated with weight loss among adults with obesity and with or at elevated risk for knee osteoarthritis.

scholarly journals Effects of an intensive weight loss program on knee joint loading in obese adults with knee osteoarthritis

2011 ◽  
Vol 19 (7) ◽  
pp. 822-828 ◽  
Author(s):  
J. Aaboe ◽  
H. Bliddal ◽  
S.P. Messier ◽  
T. Alkjær ◽  
M. Henriksen
Keyword(s):  
Weight Loss ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Weight Loss Program ◽  
Joint Loading ◽  
Obese Adults ◽  
Knee Joint Loading

scholarly journals Intensive Weight Loss Program Improves Physical Function in Older Obese Adults with Knee Osteoarthritis*

Obesity ◽  
2006 ◽  
Vol 14 (7) ◽  
pp. 1219-1230 ◽  
Author(s):  
Gary D. Miller ◽  
Barbara J. Nicklas ◽  
Cralen Davis ◽  
Richard F. Loeser ◽  
Leon Lenchik ◽  
...  
Keyword(s):  
Weight Loss ◽  
Knee Osteoarthritis ◽  
Physical Function ◽  
Weight Loss Program ◽  
Obese Adults

Comparative efficacy of different weight loss treatments on knee osteoarthritis: A network meta‐analysis

2021 ◽  
Author(s):  
Simona Panunzi ◽  
Sabina Maltese ◽  
Andrea De Gaetano ◽  
Esmeralda Capristo ◽  
Stefan R. Bornstein ◽  
...  
Keyword(s):  
Weight Loss ◽  
Knee Osteoarthritis ◽  
Meta Analysis ◽  
Comparative Efficacy ◽  
Weight Loss Treatments
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