scholarly journals Modulation of human t cell responses by nitric oxide and its derivative,s-nitrosoglutathione

1993 ◽  
Vol 36 (10) ◽  
pp. 1414-1422 ◽  
Author(s):  
Parvin F. Merryman ◽  
Robert M. Clancy ◽  
Xiao Yuen He ◽  
Steven B. Abramson
Keyword(s):  
Nitric Oxide ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Human T Cell

Human T-cell responses to oral streptococci in human PBMC-NOD/SCID mice

2006 ◽  
Vol 21 (3) ◽  
pp. 169-176 ◽  
Author(s):  
M. A. Salam ◽  
R. Nakao ◽  
H. Yonezawa ◽  
H Watanabe ◽  
H. Senpuku
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Scid Mice ◽  
Oral Streptococci ◽  
Human Pbmc ◽  
Cell Responses ◽  
Human T Cell

scholarly journals Human T cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells

2001 ◽  
Vol 94 (6) ◽  
pp. 807-812 ◽  
Author(s):  
Emma J. Davidson ◽  
Michael D. Brown ◽  
Deborah J. Burt ◽  
Joanna L. Parish ◽  
Kevin Gaston ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Hpv 16 ◽  
Cell Responses ◽  
Human T Cell

Human T cell responses to the antigen ESAT-6 characterize vaccine candidate and potential diagnostic test for tuberculosis

1999 ◽  
Vol 39 (1) ◽  
pp. A9
Author(s):  
A. Lalvani ◽  
A. Pathan ◽  
R. Brookes ◽  
H. Pritchard ◽  
R. Wilkinson ◽  
...  
Keyword(s):  
T Cell ◽  
Diagnostic Test ◽  
Vaccine Candidate ◽  
T Cell Responses ◽  
Cell Responses ◽  
Human T Cell

Human T cell responses to endogenously presented HLA-A*0201 restricted peptides of simian virus 40 large T antigen

2001 ◽  
Vol 82 (1) ◽  
pp. 155-162 ◽  
Author(s):  
Markwin P. Velders ◽  
M. Fatima Macedo ◽  
Maurizio Provenzano ◽  
Amira G. Elmishad ◽  
Hermann-Georg Holzhütter ◽  
...  
Keyword(s):  
T Cell ◽  
Simian Virus 40 ◽  
T Cell Responses ◽  
Simian Virus ◽  
T Antigen ◽  
Large T Antigen ◽  
Cell Responses ◽  
Human T Cell

Enhancement of human T cell responses to allogeneic stimuli by factor VIII concentrates

1992 ◽  
Vol 82 (1) ◽  
pp. 94-98 ◽  
Author(s):  
Alison Batchelor ◽  
C. Michael Steel ◽  
Christopher A. Ludlam
Keyword(s):  
T Cell ◽  
Factor Viii ◽  
T Cell Responses ◽  
Cell Responses ◽  
Human T Cell ◽  
Factor Viii Concentrates

scholarly journals ADP exerts P2Y12 -dependent and P2Y12 -independent effects on primary human T cell responses to stimulation

2019 ◽  
Vol 14 (1) ◽  
pp. 111-126 ◽  
Author(s):  
Harika Vemulapalli ◽  
Samara Albayati ◽  
Viren C. Patwa ◽  
Douglas G. Tilley ◽  
Alexander Y. Tsygankov ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Human T Cell ◽  
Independent Effects

scholarly journals Human T-cell responses to secreted antigen fractions of Mycobacterium tuberculosis.

1995 ◽  
Vol 63 (4) ◽  
pp. 1491-1497 ◽  
Author(s):  
H Boesen ◽  
B N Jensen ◽  
T Wilcke ◽  
P Andersen
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Human T Cell

Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice

Blood ◽  
2000 ◽  
Vol 95 (1) ◽  
pp. 212-220 ◽  
Author(s):  
Iñigo Angulo ◽  
Federico Gómez de las Heras ◽  
José F. Garcı́a-Bustos ◽  
Domingo Gargallo ◽  
M. Angeles Muñoz-Fernández ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Proliferation ◽  
T Cell ◽  
T Cell Responses ◽  
T Cell Proliferation ◽  
Intensive Chemotherapy ◽  
Suppressive Activity ◽  
Cell Responses ◽  
Nos Inhibitors ◽  
Ifn Γ

Abstract During recovery from intensive chemotherapy with cyclophosphamide (CTX), mice suffer a severe but transitory impairment in spleen cell proliferation to T-cell mitogens (Con A or anti-CD3 plus IL-2). Although CTX treatment reduced spleen T-cell cellularity, this cannot fully account for T-cell unresponsiveness. The results showed that CTX induces the colonization of spleen by an immature myeloid CD11b+Ly-6G+CD31+ population. Its presence closely correlated with the maximum inhibition of T-cell proliferation. Moreover, this suppressive activity was dependent on nitric oxide (NO) production in cultures since (1) higher amounts of nitric oxide and inducible nitric oxide synthase (iNOS) mRNA were produced in CTX spleen cells (CTX-SC) than in control splenocyte cultures and (2) NOS inhibitors greatly improved the proliferation of T lymphocytes. Nitric oxide production and suppressive activity were also dependent on endogenous interferon-γ (IFN-γ) production since anti–IFN-γ abrogated both effects. Finally, iNOS protein expression was restricted to a heterogeneous population of CD31+cells in which CD11b+Ly-6G+ cells were required to suppress T-cell proliferation. These results indicated that CTX might also cause immunosuppression by a mechanism involving the presence of immature myeloid cells with suppressor activity. This may have implications in clinical praxis since inappropriate immunotherapies in patients treated with intensive chemotherapy could lead to deleterious T-cell responses. (Blood. 2000;95:212-220)

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