Human T-Cell Responses to Islet Cell Antigens

2001 ◽  
pp. 239-251 ◽  
Author(s):  
G. Sonderstrup ◽  
I. Durinovich-Bell�
Keyword(s):  
T Cell ◽  
Islet Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Human T Cell ◽  
Islet Cell Antigens

A New Model for Analyzing Immunomodulation of T Cell Responses Induced by Oral Administration of Islet Cell Antigens

2006 ◽  
Vol 958 (1) ◽  
pp. 179-181 ◽  
Author(s):  
SØREN BREGENHOLT ◽  
MIKALA WANG ◽  
MAJA ZDRAVKOVIC ◽  
THOMAS DYRBERG ◽  
JACOB S. PETERSEN
Keyword(s):  
T Cell ◽  
Oral Administration ◽  
Islet Cell ◽  
T Cell Responses ◽  
New Model ◽  
Cell Responses ◽  
Islet Cell Antigens

Human T-cell responses to oral streptococci in human PBMC-NOD/SCID mice

2006 ◽  
Vol 21 (3) ◽  
pp. 169-176 ◽  
Author(s):  
M. A. Salam ◽  
R. Nakao ◽  
H. Yonezawa ◽  
H Watanabe ◽  
H. Senpuku
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Scid Mice ◽  
Oral Streptococci ◽  
Human Pbmc ◽  
Cell Responses ◽  
Human T Cell

scholarly journals Human T cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells

2001 ◽  
Vol 94 (6) ◽  
pp. 807-812 ◽  
Author(s):  
Emma J. Davidson ◽  
Michael D. Brown ◽  
Deborah J. Burt ◽  
Joanna L. Parish ◽  
Kevin Gaston ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Hpv 16 ◽  
Cell Responses ◽  
Human T Cell

Human T cell responses to the antigen ESAT-6 characterize vaccine candidate and potential diagnostic test for tuberculosis

1999 ◽  
Vol 39 (1) ◽  
pp. A9
Author(s):  
A. Lalvani ◽  
A. Pathan ◽  
R. Brookes ◽  
H. Pritchard ◽  
R. Wilkinson ◽  
...  
Keyword(s):  
T Cell ◽  
Diagnostic Test ◽  
Vaccine Candidate ◽  
T Cell Responses ◽  
Cell Responses ◽  
Human T Cell

Human T cell responses to endogenously presented HLA-A*0201 restricted peptides of simian virus 40 large T antigen

2001 ◽  
Vol 82 (1) ◽  
pp. 155-162 ◽  
Author(s):  
Markwin P. Velders ◽  
M. Fatima Macedo ◽  
Maurizio Provenzano ◽  
Amira G. Elmishad ◽  
Hermann-Georg Holzhütter ◽  
...  
Keyword(s):  
T Cell ◽  
Simian Virus 40 ◽  
T Cell Responses ◽  
Simian Virus ◽  
T Antigen ◽  
Large T Antigen ◽  
Cell Responses ◽  
Human T Cell

Enhancement of human T cell responses to allogeneic stimuli by factor VIII concentrates

1992 ◽  
Vol 82 (1) ◽  
pp. 94-98 ◽  
Author(s):  
Alison Batchelor ◽  
C. Michael Steel ◽  
Christopher A. Ludlam
Keyword(s):  
T Cell ◽  
Factor Viii ◽  
T Cell Responses ◽  
Cell Responses ◽  
Human T Cell ◽  
Factor Viii Concentrates

scholarly journals ADP exerts P2Y12 -dependent and P2Y12 -independent effects on primary human T cell responses to stimulation

2019 ◽  
Vol 14 (1) ◽  
pp. 111-126 ◽  
Author(s):  
Harika Vemulapalli ◽  
Samara Albayati ◽  
Viren C. Patwa ◽  
Douglas G. Tilley ◽  
Alexander Y. Tsygankov ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Human T Cell ◽  
Independent Effects

scholarly journals Human T-cell responses to secreted antigen fractions of Mycobacterium tuberculosis.

1995 ◽  
Vol 63 (4) ◽  
pp. 1491-1497 ◽  
Author(s):  
H Boesen ◽  
B N Jensen ◽  
T Wilcke ◽  
P Andersen
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Human T Cell

scholarly journals A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes Human β-Cell Replication and Survival as well as GABA’s Ability to Inhibit Inflammatory T Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Jide Tian ◽  
Hoa Dang ◽  
Nataliya Karashchuk ◽  
Irvin Xu ◽  
Daniel L. Kaufman
Keyword(s):  
T Cell ◽  
Cell Survival ◽  
Islet Cell ◽  
Cell Mass ◽  
T Cell Responses ◽  
Human Islet ◽  
Cell Replication ◽  
Cell Responses ◽  
Autoreactive T Cell

A major goal of T1D research is to develop new approaches to increase β-cell mass and control autoreactive T cell responses. GABAA-receptors (GABAA-Rs) are promising drug targets in both those regards due to their abilities to promote β-cell replication and survival, as well as inhibit autoreactive T cell responses. We previously showed that positive allosteric modulators (PAMs) of GABAA-Rs could promote rat β-cell line INS-1 and human islet cell replication in vitro. Here, we assessed whether treatment with alprazolam, a widely prescribed GABAA-R PAM, could promote β-cell survival and replication in human islets after implantation into NOD/scid mice. We observed that alprazolam treatment significantly reduced human islet cell apoptosis following transplantation and increased β-cell replication in the xenografts. Evidently, the GABAA-R PAM works in conjunction with GABA secreted from β-cells to increase β-cell survival and replication. Treatment with both the PAM and GABA further enhanced human β-cell replication. Alprazolam also augmented the ability of suboptimal doses of GABA to inhibit antigen-specific T cell responses in vitro. Thus, combined GABAA-R agonist and PAM treatment may help control inflammatory immune responses using reduced drug dosages. Together, these findings suggest that GABAA-R PAMs represent a promising drug class for safely modulating islet cells toward beneficial outcomes to help prevent or reverse T1D and, together with a GABAA-R agonist, may have broader applications for ameliorating other disorders in which inflammation contributes to the disease process.

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