scholarly journals Human T cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells

2001 ◽  
Vol 94 (6) ◽  
pp. 807-812 ◽  
Author(s):  
Emma J. Davidson ◽  
Michael D. Brown ◽  
Deborah J. Burt ◽  
Joanna L. Parish ◽  
Kevin Gaston ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Hpv 16 ◽  
Cell Responses ◽  
Human T Cell

Induction of human T cell responses to tumour-associated neoantigens and virus antigens using cultured dendritic cells

1997 ◽  
Vol 25 (2) ◽  
pp. 204S-204S ◽  
Author(s):  
JIN LI ◽  
GLORIA BOWEN ◽  
JOHN J MURPHY ◽  
HUW DAVIES ◽  
SIMON HOLLINGSWORTH ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Human T Cell ◽  
Virus Antigens

scholarly journals Profiling HPV-16–specific T cell responses reveals broad antigen reactivities in oropharyngeal cancer patients

2020 ◽  
Vol 217 (10) ◽  
Author(s):  
Kunal H. Bhatt ◽  
Michelle A. Neller ◽  
Sriganesh Srihari ◽  
Pauline Crooks ◽  
Lea Lekieffre ◽  
...  
Keyword(s):  
T Cell ◽  
Oropharyngeal Cancer ◽  
T Cell Responses ◽  
T Cell Response ◽  
Smoking History ◽  
Hpv 16 ◽  
Cell Responses ◽  
Treatment Status ◽  
Human T Cell ◽  
E6 And E7

Cellular immunotherapeutics targeting the human papillomavirus (HPV)–16 E6 and E7 proteins have achieved limited success in HPV-positive oropharyngeal cancer (OPC). Here we have conducted proteome-wide profiling of HPV-16–specific T cell responses in a cohort of 66 patients with HPV-associated OPC and 22 healthy individuals. Unexpectedly, HPV-specific T cell responses from OPC patients were not constrained to the E6 and E7 antigens; they also recognized E1, E2, E4, E5, and L1 proteins as dominant targets for virus-specific CD8+ and CD4+ T cells. Multivariate analysis incorporating tumor staging, treatment status, and smoking history revealed that treatment status had the most significant impact on HPV-specific CD8+ and CD4+ T cell immunity. Specifically, the breadth and overall strength of HPV-specific T cell responses were significantly higher before the commencement of curative therapy than after therapy. These data provide the first glimpse of the overall human T cell response to HPV in a clinical setting and offer groundbreaking insight into future development of cellular immunotherapies for HPV-associated OPC patients.

Sign in / Sign up

Export Citation Format

Share Document