scholarly journals Experimentally Induced Osteoarthritis in Guinea Pigs

1981 ◽  
Vol 24 (11) ◽  
pp. 1345-1355 ◽  
Author(s):  
Edith R. Schwartz ◽  
Won H. Oh ◽  
Cynthia R. Leveille
Keyword(s):  
Guinea Pigs ◽  
Experimentally Induced

Liver fibrosis in guinea pigs experimentally induced by combined copper and aflatoxin application

1998 ◽  
Vol 50 (4-6) ◽  
pp. 519-527 ◽  
Author(s):  
Frank Schiller ◽  
Ulrich Lippold ◽  
Rita Heinze ◽  
Allhard Hoffmann ◽  
Wolfgang Seffner
Keyword(s):  
Liver Fibrosis ◽  
Guinea Pigs ◽  
Experimentally Induced

scholarly journals STUDIES ON THE ETIOLOGY OF RABBIT POX

1936 ◽  
Vol 63 (4) ◽  
pp. 491-507 ◽  
Author(s):  
Louise Pearce ◽  
Paul D. Rosahn ◽  
Ch'uan-K'uei Hu
Keyword(s):  
Guinea Pig ◽  
Special Reference ◽  
Guinea Pigs ◽  
Fatal Outcome ◽  
White Mouse ◽  
Intradermal Injection ◽  
Cutaneous Reaction ◽  
Active Virus ◽  
Experimentally Induced

The white mouse, the guinea pig, the calf, and probably the rat, were found to be susceptible to infection with the virus of rabbit pox. Serial transmission of the virus in mice by brain to brain passage was characterized by a fatal outcome usually on the 5th or 6th day after inoculation. Infection of the guinea pig was accomplished by intratesticular injection and the virus was continued to the 2nd passage in this species. Guinea pigs developed a well marked cutaneous reaction from the intradermal injection of both rabbit and guinea pig tissue virus. Active virus was demonstrated in the testicles of rats 8 days after intratesticular injection by rabbit subinoculation. In the calf inoculation of the scarified skin was followed by the development of large papular lesions with marked hemorrhage and necrosis. The results of the investigations on the etiology of rabbit pox and of the experimentally induced infection reported in this and the four preceding papers (1–4) are discussed with special reference to the relation of pox virus to other viruses and of rabbit pox to other pock diseases.

Comparative pathology and pathogenesis of naturally acquired and experimentally induced colonic spirochetosis

2001 ◽  
Vol 2 (1) ◽  
pp. 3-18 ◽  
Author(s):  
Gerald E. Duhamel
Keyword(s):  
Guinea Pigs ◽  
Etiologic Agent ◽  
Future Research ◽  
Colonic Crypt ◽  
Epithelial Surface ◽  
Comparative Pathology ◽  
The Past ◽  
Naturally Occurring ◽  
Lower Intestine ◽  
Experimentally Induced

AbstractResearch in the past decade has led to the recognition ofBrachyspira(formerlySerpulina)pilosicolias the primary etiologic agent of colonic spirochetosis (CS), an emerging cause of colitis in humans and animals. Attachment of spirochetes to the epithelial surface of the lower intestine is considered to be the hallmark of CS. However, becauseB. pilosicoli, B. aalborgiand unclassified flagellated bacteria are found singly or together in humans and non-human primates with CS lesions, attachment of spiral-shaped bacteria may not represent the same etiopathogenetic entity in all hosts. Moreover, North American opossums with CS are infected withB. aalborgi-like spirochetes together with flagellated bacteria, whereasB. pilosicoliis found alone in dogs, pigs, chickens and other species of birds with CS. Conversely, guinea-pigs with CS have unidentified spirochetes that may beB. pilosicoli or B. aalborgi.The pig model of CS suggests that attachment ofB. pilosicolito epithelial cells may be transient. By contrast, persistence ofB. pilosicoliin the cecal and colonic crypt lumina, chronic inflammation caused by spirochetal invasion into the subepithelial lamina propria and translocation to extraintestinal sites may be more important than previously thought. This review describes the lesions seen in naturally occurring and experimentally induced CS of animals, and it sets the stage for future research into the pathogenic mechanisms of infection and colitis caused byB. pilosicoli.

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