The stuctural and functional unit in the human liver (liver acinus)

1958 ◽  
Vol 130 (4) ◽  
pp. 673-689 ◽  
Author(s):  
A. M. Rappaport ◽  
W. D. Wilson
Keyword(s):  
Human Liver ◽  
Functional Unit ◽  
Liver Acinus

scholarly journals WHAT NEED CONSIDER AS A STRUCTURAL AND FUNCTIONAL UNIT OF THE HUMAN LIVER?

2018 ◽  
Vol 26 (4) ◽  
pp. 35-38
Author(s):  
G. G. Aminova
Keyword(s):  
Human Liver ◽  
Functional Organization ◽  
Functional Unit ◽  
Liver Parenchyma ◽  
Hepatic Lobule ◽  
Common Base ◽  
Volumetric Reconstruction ◽  
The Common ◽  
Number Of Authors

The article discusses the issues of structural and functional organization of the human liver. The analysis of classical ideas in this problem is carried out and their shortcomings are shown. The data of a number of authors are presented in whose works on the reconstruction of the hepatic lobules in humans and cats it was shown that the liver parenchyma consists of complexes of the hepatic lobules. Each complex of hepatic lobules is a combination of 2-4 classic lobules, united by one common base. The central veins in the lobules of the complex begin with the 2nd third of the length of the lobule. Merging, they form a collective vein located in the common base of the lobules. The hepatic lobule complex is morphologically and functionally combined. Separate classic hepatic lobule in the liver is rare. The author proves that portal lobules and hepatic acini do not exist as real morphological structures, since their volumetric reconstruction cannot be created.

Distribution of alcohol dehydrogenase isoenzymes in the human liver acinus

1999 ◽  
Vol 111 (5) ◽  
pp. 391-397 ◽  
Author(s):  
I. Piotr Maly ◽  
Mireille Toranelli ◽  
D. Sasse
Keyword(s):  
Alcohol Dehydrogenase ◽  
Human Liver ◽  
Alcohol Dehydrogenase Isoenzymes ◽  
Liver Acinus

Endothelial cell heterogeneity in the normal human liver acinus: in situ immunohistochemical demonstration

2008 ◽  
Vol 14 (3) ◽  
pp. 113-123 ◽  
Author(s):  
Jean-Yves Scoazec ◽  
Lorraine Racine ◽  
Anne Couvelard ◽  
Jean-Francois Flejou ◽  
Gérard Feldmann
Keyword(s):  
Endothelial Cell ◽  
Human Liver ◽  
Cell Heterogeneity ◽  
Liver Acinus ◽  
Immunohistochemical Demonstration ◽  
Normal Human Liver ◽  
Endothelial Cell Heterogeneity ◽  
Normal Human

scholarly journals A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX

Lab on a Chip ◽  
2018 ◽  
Vol 18 (17) ◽  
pp. 2614-2631 ◽  
Author(s):  
Xiang Li ◽  
Subin M. George ◽  
Lawrence Vernetti ◽  
Albert H. Gough ◽  
D. Lansing Taylor
Keyword(s):  
Human Liver ◽  
Experimental Modeling ◽  
Liver Acinus

We developed a glass based, vascularized human biomimetic liver MPS recreating oxygen zonation present in the liver acinus.

scholarly journals Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

2017 ◽  
Vol 242 (16) ◽  
pp. 1617-1632 ◽  
Author(s):  
Felipe T Lee-Montiel ◽  
Subin M George ◽  
Albert H Gough ◽  
Anup D Sharma ◽  
Juanfang Wu ◽  
...  
Keyword(s):  
Oxygen Tension ◽  
Human Liver ◽  
Imaging Method ◽  
Porcine Liver ◽  
Current Form ◽  
Liver Acinus ◽  
Wide Range ◽  
Liver Functions ◽  
The Impact

This article describes our next generation human Liver Acinus MicroPhysiology System (LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 microenvironments can be established by controlling the oxygen tension in individual devices over the range of ca. 3 to 13%. The oxygen tension was computationally modeled using input on the microfluidic device dimensions, numbers of cells, oxygen consumption rates of hepatocytes, the diffusion coefficients of oxygen in different materials and the flow rate of media in the MicroPhysiology System (MPS). In addition, the oxygen tension was measured using a ratiometric imaging method with the oxygen sensitive dye, Tris(2,2′-bipyridyl) dichlororuthenium(II) hexahydrate (RTDP) and the oxygen insensitive dye, Alexa 488. The Zone 1 biased functions of oxidative phosphorylation, albumin and urea secretion and Zone 3 biased functions of glycolysis, α1AT secretion, Cyp2E1 expression and acetaminophen toxicity were demonstrated in the respective Zone 1 and Zone 3 MicroPhysiology System. Further improvements in the Liver Acinus MicroPhysiology System included improved performance of selected nonparenchymal cells, the inclusion of a porcine liver extracellular matrix to model the Space of Disse, as well as an improved media to support both hepatocytes and non-parenchymal cells. In its current form, the Liver Acinus MicroPhysiology System is most amenable to low to medium throughput, acute through chronic studies, including liver disease models, prioritizing compounds for preclinical studies, optimizing chemistry in structure activity relationship (SAR) projects, as well as in rising dose studies for initial dose ranging. Impact statement Oxygen zonation is a critical aspect of liver functions. A human microphysiology system is needed to investigate the impact of zonation on a wide range of liver functions that can be experimentally manipulated. Because oxygen zonation has such diverse physiological effects in the liver, we developed and present a method for computationally modeling and measuring oxygen that can easily be implemented in all MPS models. We have applied this method in a liver MPS in which we are then able to control oxygenation in separate devices and demonstrate that zonation-dependent hepatocyte functions in the MPS recapitulate what is known about in vivo liver physiology. We believe that this advance allows a deep experimental investigation on the role of zonation in liver metabolism and disease. In addition, modeling and measuring oxygen tension will be required as investigators migrate from PDMS to plastic and glass devices.

Functional and anatomic heterogeneity in the liver acinus: impact on transport

1983 ◽  
Vol 244 (6) ◽  
pp. G578-G582
Author(s):  
J. J. Gumucio
Keyword(s):  
Plasma Protein ◽  
Functional Unit ◽  
Solute Concentration ◽  
Similar Concentration ◽  
Hepatic Parenchyma ◽  
Specific Chemical ◽  
Solute Exchange ◽  
Liver Acinus ◽  
Inlet Zone ◽  
Chemical Groups

The site of solute exchange between blood and hepatocytes is the liver acinus, the structural and functional unit of hepatic parenchyma. Because the perfusion of acinar hepatocytes occurs in a sequential manner, differences in solute concentration between hepatocytes located at the inlet (zone 1) and at the outlet (zone 3) of the acinus are predictable. However, the distribution and transport of solutes by hepatocytes of each acinar zone also seem to be influenced by factors other than the sequential perfusion of blood. The concentration of receptors in hepatocytes at each zone, the presence of specific chemical groups on the incoming molecules, and the binding of the solutes to plasma protein are all factors that modify the interaction with, and the cellular concentration attained by, solutes in each acinar zone. Therefore, solute concentration in hepatocytes of each acinar zone may produce a profile of decreasing solute concentration from cells in zone 1 to those in zone 3, a reverse profile from zone 3 to zone 1, or a similar concentration in all hepatocytes.

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Author response for "Human liver‐derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR‐independent activation"

2020 ◽  
Author(s):  
Rajesh Lamichhane ◽  
Fran Munro ◽  
Thomas W. R. Harrop ◽  
Sara M. Harpe ◽  
Peter K. Dearden ◽  
...  
Keyword(s):  
Human Liver ◽  
Author Response ◽  
Mait Cells

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

2000 ◽  
Vol 86 (5) ◽  
pp. 215-221 ◽  
Author(s):  
Paivi Taavitsainen ◽  
Markku Anttila ◽  
Leena Nyman ◽  
Hari Karnani ◽  
Jarmo S. Salonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Vitro Study
Sign in / Sign up

Export Citation Format

Share Document