HISTOPATHOLOGIC CHANGES IN THE STRUCTURAL AND FUNCTIONAL UNIT OF THE HUMAN LIVER

1958 ◽  
Vol 32 (3) ◽  
pp. 240-255 ◽  
Author(s):  
A.M. Rappaport ◽  
G.Y. Hiraki
Keyword(s):  
Human Liver ◽  
Functional Unit ◽  
Histopathologic Changes

The stuctural and functional unit in the human liver (liver acinus)

1958 ◽  
Vol 130 (4) ◽  
pp. 673-689 ◽  
Author(s):  
A. M. Rappaport ◽  
W. D. Wilson
Keyword(s):  
Human Liver ◽  
Functional Unit ◽  
Liver Acinus

scholarly journals WHAT NEED CONSIDER AS A STRUCTURAL AND FUNCTIONAL UNIT OF THE HUMAN LIVER?

2018 ◽  
Vol 26 (4) ◽  
pp. 35-38
Author(s):  
G. G. Aminova
Keyword(s):  
Human Liver ◽  
Functional Organization ◽  
Functional Unit ◽  
Liver Parenchyma ◽  
Hepatic Lobule ◽  
Common Base ◽  
Volumetric Reconstruction ◽  
The Common ◽  
Number Of Authors

The article discusses the issues of structural and functional organization of the human liver. The analysis of classical ideas in this problem is carried out and their shortcomings are shown. The data of a number of authors are presented in whose works on the reconstruction of the hepatic lobules in humans and cats it was shown that the liver parenchyma consists of complexes of the hepatic lobules. Each complex of hepatic lobules is a combination of 2-4 classic lobules, united by one common base. The central veins in the lobules of the complex begin with the 2nd third of the length of the lobule. Merging, they form a collective vein located in the common base of the lobules. The hepatic lobule complex is morphologically and functionally combined. Separate classic hepatic lobule in the liver is rare. The author proves that portal lobules and hepatic acini do not exist as real morphological structures, since their volumetric reconstruction cannot be created.

Cytopathology of Cardiac Tissue from Daunomycin-Treated Mice

1971 ◽  
Vol 29 ◽  
pp. 550-551
Author(s):  
Robert H. Liss ◽  
Frances A. Cotton
Keyword(s):  
Cardiac Tissue ◽  
Cardiac Toxicity ◽  
Drug Distribution ◽  
Personal Communication ◽  
Intravenous Dose ◽  
Single Intravenous Dose ◽  
Physiologic Saline ◽  
Histopathologic Changes ◽  
Distribution Studies ◽  
Lung And Kidney

Daunomycin, an antibiotic used in the clinical management of acute leukemia, produces a delayed, lethal cardiac toxicity. The lethality is dose and schedule dependent; histopathologic changes induced by the drug have been described in heart, lung, and kidney from hamsters in both single and multiple dose studies. Mice given a single intravenous dose of daunomycin (10 mg/kg) die 6-7 days later. Drug distribution studies indicate that the rodents excrete most of a single dose of the drug as daunomycin and metabolite within 48 hours after dosage (M. A. Asbell, personal communication).Myocardium from the ventricles of 6 moribund BDF1 mice which had received a single intravenous dose of daunomycin (10 mg/kg), and from controls dosed with physiologic saline, was fixed in glutaraldehyde and prepared for electron microscopy.

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Author response for "Human liver‐derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR‐independent activation"

2020 ◽  
Author(s):  
Rajesh Lamichhane ◽  
Fran Munro ◽  
Thomas W. R. Harrop ◽  
Sara M. Harpe ◽  
Peter K. Dearden ◽  
...  
Keyword(s):  
Human Liver ◽  
Author Response ◽  
Mait Cells

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

2000 ◽  
Vol 86 (5) ◽  
pp. 215-221 ◽  
Author(s):  
Paivi Taavitsainen ◽  
Markku Anttila ◽  
Leena Nyman ◽  
Hari Karnani ◽  
Jarmo S. Salonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Vitro Study

Human Liver Cocaine Carboxylesterases

1997 ◽  
Author(s):  
William F. Bosron ◽  
Robert A. Dean ◽  
Monica R. Brzezinski ◽  
Evgenia V. Pindel
Keyword(s):  
Human Liver

Human liver cell cultivation for long-term in vitro toxicity studies in a miniaturized multi-compartment 3D bioreactor system

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
SA Hoffmann ◽  
M Lübberstedt ◽  
U Müller-Vieira ◽  
D Knobeloch ◽  
A Nüssler ◽  
...  
Keyword(s):  
Liver Cell ◽  
Human Liver ◽  
In Vitro Toxicity ◽  
Cell Cultivation ◽  
Toxicity Studies ◽  
Human Liver Cell ◽  
Bioreactor System
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