Designing crosslinked hyaluronic acid hydrogels with tunable mechanical properties for biomedical applications

2015 ◽  
Vol 132 (22) ◽  
pp. n/a-n/a ◽  
Author(s):  
Anahita Khanlari ◽  
Jason E. Schulteis ◽  
Tiffany C. Suekama ◽  
Michael S. Detamore ◽  
Stevin H. Gehrke
Keyword(s):  
Mechanical Properties ◽  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Tunable Mechanical Properties

scholarly journals Design of Biomimetic Cell-Interactive Substrates Using Hyaluronic Acid Hydrogels with Tunable Mechanical Properties

2012 ◽  
Vol 13 (6) ◽  
pp. 1818-1827 ◽  
Author(s):  
Emilie Hachet ◽  
Hélène Van Den Berghe ◽  
Eric Bayma ◽  
Marc R. Block ◽  
Rachel Auzély-Velty
Keyword(s):  
Mechanical Properties ◽  
Hyaluronic Acid ◽  
Tunable Mechanical Properties

The Antigenicity of Silk-Based Materials: Source, influential factors and applications

2021 ◽  
Author(s):  
Lili Chen ◽  
Yanlin Long ◽  
Xian Cheng ◽  
Qingming Tang
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Influential Factors ◽  
Tunable Mechanical Properties

Silk is an ancient material which acts important roles in numerous biomedical applications, such as tissue regeneration, drug delivery, because of its excellent tunable mechanical properties and diverse physical structures....

Cross-linked PMS/PLA nanofibers with tunable mechanical properties and degradation rate for biomedical applications

2020 ◽  
Vol 130 ◽  
pp. 109633
Author(s):  
Mahya Rahmani ◽  
Reza Faridi-Majidi ◽  
Mohammad-Mehdi Khani ◽  
Alireza Mashaghi ◽  
Farsad Noorizadeh ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Biomedical Applications ◽  
Degradation Rate ◽  
Tunable Mechanical Properties

In situ photocrosslinkable hyaluronic acid-based surgical glue with tunable mechanical properties and high adhesive strength

2018 ◽  
Vol 57 (4) ◽  
pp. 522-530 ◽  
Author(s):  
Ajeesh Chandrasekharan ◽  
Keum-Yong Seong ◽  
Sang-Gu Yim ◽  
Sodam Kim ◽  
Sungbaek Seo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Hyaluronic Acid ◽  
Adhesive Strength ◽  
Tunable Mechanical Properties ◽  
High Adhesive Strength

The effects of hyaluronic acid hydrogels with tunable mechanical properties on neural progenitor cell differentiation

Biomaterials ◽  
2010 ◽  
Vol 31 (14) ◽  
pp. 3930-3940 ◽  
Author(s):  
Stephanie K. Seidlits ◽  
Zin Z. Khaing ◽  
Rebecca R. Petersen ◽  
Jonathan D. Nickels ◽  
Jennifer E. Vanscoy ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Hyaluronic Acid ◽  
Cell Differentiation ◽  
Progenitor Cell ◽  
Neural Progenitor Cell ◽  
Neural Progenitor ◽  
Tunable Mechanical Properties

Cellulose Nanofibrils-based Hydrogels for Biomedical Applications: Progresses and Challenges

2020 ◽  
Vol 27 (28) ◽  
pp. 4622-4646 ◽  
Author(s):  
Huayu Liu ◽  
Kun Liu ◽  
Xiao Han ◽  
Hongxiang Xie ◽  
Chuanling Si ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Metal Ion ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Cellulose Nanofibrils ◽  
Wound Dressings ◽  
Preparation Methods ◽  
Tissue Scaffold ◽  
Surface Areas ◽  
Mechanical Methods

Background: Cellulose Nanofibrils (CNFs) are natural nanomaterials with nanometer dimensions. Compared with ordinary cellulose, CNFs own good mechanical properties, large specific surface areas, high Young's modulus, strong hydrophilicity and other distinguishing characteristics, which make them widely used in many fields. This review aims to introduce the preparation of CNFs-based hydrogels and their recent biomedical application advances. Methods: By searching the recent literatures, we have summarized the preparation methods of CNFs, including mechanical methods and chemical mechanical methods, and also introduced the fabrication methods of CNFs-based hydrogels, including CNFs cross-linked with metal ion and with polymers. In addition, we have summarized the biomedical applications of CNFs-based hydrogels, including scaffold materials and wound dressings. Results: CNFs-based hydrogels are new types of materials that are non-toxic and display a certain mechanical strength. In the tissue scaffold application, they can provide a micro-environment for the damaged tissue to repair and regenerate it. In wound dressing applications, it can fit the wound surface and protect the wound from the external environment, thereby effectively promoting the healing of skin tissue. Conclusion: By summarizing the preparation and application of CNFs-based hydrogels, we have analyzed and forecasted their development trends. At present, the research of CNFs-based hydrogels is still in the laboratory stage. It needs further exploration to be applied in practice. The development of medical hydrogels with high mechanical properties and biocompatibility still poses significant challenges.

scholarly journals 3D Printing of High Viscosity Reinforced Silicone Elastomers

Polymers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 2239
Author(s):  
Nicholas Rodriguez ◽  
Samantha Ruelas ◽  
Jean-Baptiste Forien ◽  
Nikola Dudukovic ◽  
Josh DeOtte ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
High Performance ◽  
New Technologies ◽  
Three Dimensional ◽  
High Viscosity ◽  
Layer By Layer ◽  
Silicone Elastomers ◽  
Uv Curable ◽  
Octet Truss ◽  
Tunable Mechanical Properties

Recent advances in additive manufacturing, specifically direct ink writing (DIW) and ink-jetting, have enabled the production of elastomeric silicone parts with deterministic control over the structure, shape, and mechanical properties. These new technologies offer rapid prototyping advantages and find applications in various fields, including biomedical devices, prosthetics, metamaterials, and soft robotics. Stereolithography (SLA) is a complementary approach with the ability to print with finer features and potentially higher throughput. However, all high-performance silicone elastomers are composites of polysiloxane networks reinforced with particulate filler, and consequently, silicone resins tend to have high viscosities (gel- or paste-like), which complicates or completely inhibits the layer-by-layer recoating process central to most SLA technologies. Herein, the design and build of a digital light projection SLA printer suitable for handling high-viscosity resins is demonstrated. Further, a series of UV-curable silicone resins with thiol-ene crosslinking and reinforced by a combination of fumed silica and MQ resins are also described. The resulting silicone elastomers are shown to have tunable mechanical properties, with 100–350% elongation and ultimate tensile strength from 1 to 2.5 MPa. Three-dimensional printed features of 0.4 mm were achieved, and complexity is demonstrated by octet-truss lattices that display negative stiffness.

scholarly journals Dynamic Mechanical Control of Alginate-Fibronectin Hydrogels with Dual Crosslinking: Covalent and Ionic

Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 433
Author(s):  
Sara Trujillo ◽  
Melanie Seow ◽  
Aline Lueckgen ◽  
Manuel Salmeron-Sanchez ◽  
Amaia Cipitria
Keyword(s):  
Mechanical Properties ◽  
Biomedical Applications ◽  
Divalent Cations ◽  
Dynamic Control ◽  
Dynamic Mechanical Properties ◽  
Full Length ◽  
Dynamic Mechanical ◽  
Covalent Crosslinking ◽  
Calcium Cations ◽  
Different Tissues

Alginate is a polysaccharide used extensively in biomedical applications due to its biocompatibility and suitability for hydrogel fabrication using mild reaction chemistries. Though alginate has commonly been crosslinked using divalent cations, covalent crosslinking chemistries have also been developed. Hydrogels with tuneable mechanical properties are required for many biomedical applications to mimic the stiffness of different tissues. Here, we present a strategy to engineer alginate hydrogels with tuneable mechanical properties by covalent crosslinking of a norbornene-modified alginate using ultraviolet (UV)-initiated thiol-ene chemistry. We also demonstrate that the system can be functionalised with cues such as full-length fibronectin and protease-degradable sequences. Finally, we take advantage of alginate’s ability to be crosslinked covalently and ionically to design dual crosslinked constructs enabling dynamic control of mechanical properties, with gels that undergo cycles of stiffening–softening by adding and quenching calcium cations. Overall, we present a versatile hydrogel with tuneable and dynamic mechanical properties, and incorporate cell-interactive features such as cell-mediated protease-induced degradability and full-length proteins, which may find applications in a variety of biomedical contexts.

scholarly journals Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Erfan Dashtimoghadam ◽  
Farahnaz Fahimipour ◽  
Andrew N. Keith ◽  
Foad Vashahi ◽  
Pavel Popryadukhin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Reconstructive Surgery ◽  
Biomedical Applications ◽  
The Body ◽  
Surrounding Tissue ◽  
Curing Time ◽  
Materials Used ◽  
Significant Health

AbstractCurrent materials used in biomedical devices do not match tissue’s mechanical properties and leach various chemicals into the body. These deficiencies pose significant health risks that are further exacerbated by invasive implantation procedures. Herein, we leverage the brush-like polymer architecture to design and administer minimally invasive injectable elastomers that cure in vivo into leachable-free implants with mechanical properties matching the surrounding tissue. This strategy allows tuning curing time from minutes to hours, which empowers a broad range of biomedical applications from rapid wound sealing to time-intensive reconstructive surgery. These injectable elastomers support in vitro cell proliferation, while also demonstrating in vivo implant integrity with a mild inflammatory response and minimal fibrotic encapsulation.

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