scholarly journals Liposome Microencapsulation for the Surface Modification and Improved Entrapment of Cytochrome c for Targeted Delivery

2018 ◽  
Vol 95 (1) ◽  
pp. 101-109 ◽  
Author(s):  
Kazuaki Kajimoto ◽  
Tatsuhito Katsumi ◽  
Takashi Nakamura ◽  
Masatoshi Kataoka ◽  
Hideyoshi Harashima
Keyword(s):  
Surface Modification ◽  
Cytochrome C ◽  
Targeted Delivery

scholarly journals Ferritin nanovehicle for targeted delivery of cytochrome C to cancer cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alberto Macone ◽  
Silvia Masciarelli ◽  
Federica Palombarini ◽  
Deborah Quaglio ◽  
Alberto Boffi ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Cancer Cells ◽  
Targeted Delivery

scholarly journals Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195542 ◽  
Author(s):  
Manoj Saxena ◽  
Yamixa Delgado ◽  
Rohit Kumar Sharma ◽  
Shweta Sharma ◽  
Solimar Liz Ponce De León Guzmán ◽  
...  
Keyword(s):  
Cell Death ◽  
Cytochrome C ◽  
Cancer Cells ◽  
Targeted Delivery

scholarly journals Comprehensive Study of Ni Nanotubes for Bioapplications: From Synthesis to Payloads Attaching

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
A. L. Kozlovskiy ◽  
I. V. Korolkov ◽  
G. Kalkabay ◽  
M. A. Ibragimova ◽  
A. D. Ibrayeva ◽  
...  
Keyword(s):  
Surface Modification ◽  
Targeted Delivery ◽  
Uniform Magnetic Field ◽  
Organosilicon Compound ◽  
Biomedical Application ◽  
Specific Density ◽  
Full Control ◽  
Nanostructure Surface ◽  
Synthesis Stage ◽  
Comprehensive Study

Due to the Ni nanotubes’ shape anisotropy, low specific density, large specific surface, and uniform magnetic field, they have been offered as carriers for targeted delivery of drug or protein and the process of their formation from synthesis stage to the stage of surface modification and protein attaching has been demonstrated. Some steps to hasten their biomedical application have been applied. First, to have full control over the carrier dimensions and structure parameters, electrodeposition method in pores of polyethylene terephthalate template has been applied. Second, to understand the scope of Ni nanostructures application, their degradation in media with different acidity has been studied. Third, to improve the biocompatibility and to make payloads attachment possible, nanotubes surface modification with organosilicon compound has been carried out. At last, the scheme of protein attaching to the nanostructure surface has been developed and the binding process was demonstrated as an example of the bovine serum albumin.

scholarly journals Correction: In situ surface modification of bulk or nano materials by cytochrome-c for active hydrogen evolution catalysis

2021 ◽  
Vol 5 (5) ◽  
pp. 2470-2470
Author(s):  
Pallavi Thakur ◽  
Jamsad Mannuthodikayil ◽  
Golap Kalita ◽  
Kalyaneswar Mandal ◽  
Tharangattu N. Narayanan
Keyword(s):  
Surface Modification ◽  
Cytochrome C ◽  
Hydrogen Evolution ◽  
Nano Materials ◽  
Active Hydrogen

Correction for ‘In situ surface modification of bulk or nano materials by cytochrome-c for active hydrogen evolution catalysis’ by Pallavi Thakur et al., Mater. Chem. Front., 2021, 5, 1295–1300, DOI: 10.1039/D0QM00627K.

Abstract 2179: Targeted delivery of nanoparticulate cytochrome c into GL261 glioma cells through the proton-coupled folate transporter

2017 ◽  
Author(s):  
Yuriy Kucheryavykh ◽  
Jescelica Ortiz-Rivera ◽  
Michael Inyushin ◽  
Luis Cubano ◽  
Moraima Morales-Cruz ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Targeted Delivery ◽  
Glioma Cells ◽  
Gl261 Glioma

In situ surface modification of bulk or nano materials by cytochrome-c for active hydrogen evolution catalysis

2021 ◽  
Author(s):  
Pallavi Thakur ◽  
Jamsad Mannuthodikayil ◽  
Golap Kalita ◽  
Kalyaneswar Mandal ◽  
Tharangattu N. Narayanan
Keyword(s):  
Surface Modification ◽  
Cytochrome C ◽  
Hydrogen Evolution ◽  
Nano Materials ◽  
Active Hydrogen ◽  
Catalyst Development ◽  
P Protein

Protein assisted electrochemical hydrogen evolution catalyst development has been proposed here.

scholarly journals Surface Modification of Liposomes by a Lipopolymer Targeting Prostate Specific Membrane Antigen for Theranostic Delivery in Prostate Cancer

Materials ◽  
2019 ◽  
Vol 12 (5) ◽  
pp. 756 ◽  
Author(s):  
Hooman Yari ◽  
Gregory Nkepang ◽  
Vibhudutta Awasthi
Keyword(s):  
Prostate Cancer ◽  
Surface Modification ◽  
Surface Functionalization ◽  
Targeted Delivery ◽  
Prostate Specific Membrane Antigen ◽  
Lncap Cells ◽  
Binding Motifs ◽  
Ic50 Value ◽  
Pc3 Cells ◽  
Specific Membrane

Prostate specific membrane antigen (PSMA) is a marker for diagnosis and targeted delivery of therapeutics to advanced/metastasized prostate cancer. We report a liposome-based system for theranostic delivery to PSMA-expressing (PSMA+) LNCaP cells. A lipopolymer (P3) comprising of PSMA ligand (PSMAL), polyethylene glycol (PEG2000), and palmitate was synthesized and post-inserted into the surface of preformed liposomes. These P3-liposomes were loaded with doxorubicin and radiolabeled with 99mTc radionuclide to study their theranostic characteristics. Differential expression of PSMA on LNCaP and PC3 cells was confirmed by immunoblotting as well as by uptake of PSMAL labeled with 18F radionuclide. We found that the uptake of 99mTc-labeled P3-liposomes by LNCaP cells was >3-fold higher than 99mTc-labeled Plain-liposomes; the amount of doxorubicin delivered to LNCaP cells was also found to be >3-fold higher by P3-liposomes. Cell-based cytotoxicity assay results showed that doxorubicin-loaded P3-liposomes were significantly more toxic to LNCaP cells (p < 0.05), but not to PSMA-negative PC3 cells. Compared to doxorubicin-loaded Plain-liposomes, the IC50 value of doxorubicin-loaded P3-liposomes was reduced by ~5-fold in LNCaP cells. Together, these results suggest that surface functionalization of liposomes with small PSMA-binding motifs, such as PSMAL, can provide a viable platform for specific delivery of theranostics to PSMA+ prostate cancer.

scholarly journals Targeted Delivery of Nanoparticulate Cytochrome C into Glioma Cells Through the Proton-Coupled Folate Transporter

Biomolecules ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 154 ◽  
Author(s):  
Yuriy V. Kucheryavykh ◽  
Josue Davila ◽  
Jescelica Ortiz-Rivera ◽  
Mikhael Inyushin ◽  
Luis Almodovar ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Targeted Delivery ◽  
Folate Receptor ◽  
Glioma Cells ◽  
Confocal Imaging ◽  
Patch Clamp Recording ◽  
Whole Cell Patch Clamp ◽  
Cultured Astrocytes ◽  
Starting Point ◽  
Cyt C

In this study, we identified the proton-coupled folate transporter (PCFT) as a route for targeted delivery of drugs to some gliomas. Using the techniques of confocal imaging, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and small interfering (siRNA) knockdown against the PCFT, we demonstrated that Gl261 and A172 glioma cells, but not U87 and primary cultured astrocytes, express the PCFT, which provides selective internalization of folic acid (FA)-conjugated cytochrome c-containing nanoparticles (FA-Cyt c NPs), followed by cell death. The FA-Cyt c NPs (100 µg/mL), had no cytotoxic effects in astrocytes but caused death in glioma cells, according to their level of expression of PCFT. Whole-cell patch clamp recording revealed FA-induced membrane currents in FA-Cyt c NPs-sensitive gliomas, that were reduced by siRNA PCFT knockdown in a similar manner as by application of FA-Cyt c NPs, indicating that the PCFT is a route for internalization of FA-conjugated NPs in these glioma cells. Analysis of human glioblastoma specimens revealed that at least 25% of glioblastomas express elevated level of either PCFT or folate receptor (FOLR1). We conclude that the PCFT provides a mechanism for targeted delivery of drugs to some gliomas as a starting point for the development of efficient methods for treating gliomas with high expression of PCFT and/or FOLR1.

Sign in / Sign up

Export Citation Format

Share Document