Redox-Sensitive and Intrinsically Fluorescent Photoclick Hyaluronic Acid Nanogels for Traceable and Targeted Delivery of Cytochrome c to Breast Tumor in Mice

2016 ◽  
Vol 8 (33) ◽  
pp. 21155-21162 ◽  
Author(s):  
Shuai Li ◽  
Jian Zhang ◽  
Chao Deng ◽  
Fenghua Meng ◽  
Lin Yu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cytochrome C ◽  
Targeted Delivery ◽  
Breast Tumor

scholarly journals Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy

Crystals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 321
Author(s):  
Shenghui Zhong ◽  
Peng Liu ◽  
Jinsong Ding ◽  
Wenhu Zhou
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
High Dose ◽  
One Pot ◽  
Inflammatory Site ◽  
Pei Nanoparticles ◽  
Toxic Reactions

Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA); however, long-term and high-dose usage of MTX for patients can cause many side effects and toxic reactions. To address these difficulties, selectively delivering MTX to the inflammatory site of a joint is promising in the treatment of RA. In this study, we prepared MTX-PEI@HA nanoparticles (NPs), composed of hyaluronic acid (HA) as the hydrophilic negative electrical shell, and MTX-linked branched polyethyleneimine (MTX-PEI) NPs as the core. MTX-PEI@HA NPs were prepared in the water phase by a one-pot method. The polymeric NPs were selectively internalized via CD44 receptor-mediated endocytosis in the activated macrophages. In the in vivo mice mode study, treatment with MTX-PEI@HA NPs mitigated inflammatory arthritis with notable safety at a high dose of MTX. We highlight the distinct advantages of aqueous-synthesized NPs coated with HA for arthritis-selective targeted delivery, thus verifying MTX-PEI@HA NPs as a promising MTX-based nanoplatform for treatment of RA.

Mitochondrial Targeted Doxorubicin-Triphenylphosphonium Delivered by Hyaluronic Acid Modified and pH Responsive Nanocarriers to Breast Tumor: in Vitro and in Vivo Studies

2018 ◽  
Vol 15 (3) ◽  
pp. 882-891 ◽  
Author(s):  
Hui-Na Liu ◽  
Ning-Ning Guo ◽  
Tian-Tian Wang ◽  
Wang-Wei Guo ◽  
Meng-Ting Lin ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Breast Tumor ◽  
In Vivo Studies ◽  
Ph Responsive

scholarly journals Ferritin nanovehicle for targeted delivery of cytochrome C to cancer cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alberto Macone ◽  
Silvia Masciarelli ◽  
Federica Palombarini ◽  
Deborah Quaglio ◽  
Alberto Boffi ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Cancer Cells ◽  
Targeted Delivery

scholarly journals Liposome Microencapsulation for the Surface Modification and Improved Entrapment of Cytochrome c for Targeted Delivery

2018 ◽  
Vol 95 (1) ◽  
pp. 101-109 ◽  
Author(s):  
Kazuaki Kajimoto ◽  
Tatsuhito Katsumi ◽  
Takashi Nakamura ◽  
Masatoshi Kataoka ◽  
Hideyoshi Harashima
Keyword(s):  
Surface Modification ◽  
Cytochrome C ◽  
Targeted Delivery

scholarly journals Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195542 ◽  
Author(s):  
Manoj Saxena ◽  
Yamixa Delgado ◽  
Rohit Kumar Sharma ◽  
Shweta Sharma ◽  
Solimar Liz Ponce De León Guzmán ◽  
...  
Keyword(s):  
Cell Death ◽  
Cytochrome C ◽  
Cancer Cells ◽  
Targeted Delivery
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