scholarly journals Comprehensive Study of Ni Nanotubes for Bioapplications: From Synthesis to Payloads Attaching

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
A. L. Kozlovskiy ◽  
I. V. Korolkov ◽  
G. Kalkabay ◽  
M. A. Ibragimova ◽  
A. D. Ibrayeva ◽  
...  
Keyword(s):  
Surface Modification ◽  
Targeted Delivery ◽  
Uniform Magnetic Field ◽  
Organosilicon Compound ◽  
Biomedical Application ◽  
Specific Density ◽  
Full Control ◽  
Nanostructure Surface ◽  
Synthesis Stage ◽  
Comprehensive Study

Due to the Ni nanotubes’ shape anisotropy, low specific density, large specific surface, and uniform magnetic field, they have been offered as carriers for targeted delivery of drug or protein and the process of their formation from synthesis stage to the stage of surface modification and protein attaching has been demonstrated. Some steps to hasten their biomedical application have been applied. First, to have full control over the carrier dimensions and structure parameters, electrodeposition method in pores of polyethylene terephthalate template has been applied. Second, to understand the scope of Ni nanostructures application, their degradation in media with different acidity has been studied. Third, to improve the biocompatibility and to make payloads attachment possible, nanotubes surface modification with organosilicon compound has been carried out. At last, the scheme of protein attaching to the nanostructure surface has been developed and the binding process was demonstrated as an example of the bovine serum albumin.

scholarly journals Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2896
Author(s):  
Sara Ferraris ◽  
Silvia Spriano ◽  
Alessandro Calogero Scalia ◽  
Andrea Cochis ◽  
Lia Rimondini ◽  
...  
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Electrospun Fibers ◽  
Natural Polymers ◽  
Polymeric Fibers ◽  
Biological Phenomena ◽  
Proper Design ◽  
Synthetic And Natural Polymers ◽  
Selection Of

Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.

scholarly journals Influence of Annealing Temperature on Corrosion Resistance of TiO2 Nanotubes Grown on Ti–30Ta Alloy

Metals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1106
Author(s):  
Patricia Capellato ◽  
Daniela Sachs ◽  
Filipe Bueno Vilela ◽  
Mirian M. Melo ◽  
Gilbert Silva ◽  
...  
Keyword(s):  
Surface Modification ◽  
Electrochemical Behavior ◽  
Anatase Phase ◽  
Saturated Calomel Electrode ◽  
Reference Electrode ◽  
Annealing Treatment ◽  
Sweep Rate ◽  
Tio2 Nanotube ◽  
X Ray Diffraction ◽  
Nanostructure Surface

With little success, researchers has been searching for alloys with elements such as tantalum to improve the long-term life of implants. The Ti–30Ta alloy presents an elastic modulus E = 69 GPa that is close to that of bone (E = 17–25 GPa) than Ti cp (E = 105 GPa). In addition, nanostructure surface modification influences cell behavior and antimicrobial activity. So, this study investigates the corrosion behavior of surface modification by TiO2 nanotube grown on Ti–30Ta alloy after anodization process in the electrolyte glycerol + NH4F 0.25% at 30 V, for nine hours without annealing and annealed in 450 °C, 530 °C and 600 °C (5 °C/min). The electrochemical behavior was evaluated by three electrodes cell. The counter-electrode of graphite, reference-electrode of saturated calomel electrode and working-electrode at electrolyte of 0.15 M NaCl + 0.03 M NaF, with pH = 6 for 8000 s. The scanned region ranged from −0.8 V to values up to 3.5 V with a sweep rate 0.166 mV/s. Potentiodynamic polarization curves were obtained with a potentiostat. The sample was characterized by scanning electron microscopy (SEM) imaging, X-ray diffraction analysis (XRD) and wettability with a contact angle goniometer. We concludes from the obtained results that all treatment surfaces are hydrophilic (<90°). The surface covered with TiO2 nanotube crystallinity showed anatase phase after annealing at 450 °C, 530 °C and 600 °C; the exceptions were the anodized-without-annealing treatment and without-surface-modification alloys. The electrochemical behavior of the five groups investigated showed similar high resistance to corrosion solution under all conditions.

scholarly journals Liposome Microencapsulation for the Surface Modification and Improved Entrapment of Cytochrome c for Targeted Delivery

2018 ◽  
Vol 95 (1) ◽  
pp. 101-109 ◽  
Author(s):  
Kazuaki Kajimoto ◽  
Tatsuhito Katsumi ◽  
Takashi Nakamura ◽  
Masatoshi Kataoka ◽  
Hideyoshi Harashima
Keyword(s):  
Surface Modification ◽  
Cytochrome C ◽  
Targeted Delivery

scholarly journals Optimization of Anodization Parameters in Ti-30Ta Alloy

Metals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1059
Author(s):  
Patricia Capellato ◽  
Daniela Sachs ◽  
Lucas V. B. Vasconcelos ◽  
Miriam M. Melo ◽  
Gilbert Silva ◽  
...  
Keyword(s):  
Surface Modification ◽  
Biomedical Application ◽  
Anatase Phase ◽  
X Ray Diffraction ◽  
Bulk Alloy ◽  
Force Microscopy ◽  
Atomic Force ◽  
Anodization Process ◽  
Metallic Biomaterial ◽  
Cold Worked

The current metallic biomaterial still presents failures associated with the bulk alloy and the interface of material/human body. In previous studies, titanium alloy with tantalum showed the elastic modulus decrease in comparison with that of commercially pure (cp) titanium. In this study, surface modification on Ti-30Ta alloy was investigated. Titanium and tantalum were melted, homogenized, cold-worked by a rotary swaging process and solubilized. The anodization process was performed in electrolyte contained glycerol + NH4F 0.25% at 30 V using seven different durations—4 h, 5 h, 6 h, 7 h, 8 h, 9 h, and 10 h and annealed at 530 °C for 1 h. The surface topography was characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM) measurements, X-ray diffraction analysis (XRD), and contact angle. From the results, we conclude the time of anodization process influences the shape and morphology of the anodized layer. The 5 h-anodization process produced a smooth and porous surface. The 4-, 6-, 7-, 8-, 9-, and 10-h conditions showed nanotubes morphology. All surfaces are hydrophilic (<90°). Likewise, all the investigated conditions present anatase phase. So, this surface modification presents potential for biomedical application. However, more work needs to be done to better understand the influence of time on the anodization process.

scholarly journals Surface Modification of Titanium and its Alloys for Biomedical Application

2014 ◽  
Vol 887-888 ◽  
pp. 1115-1120 ◽  
Author(s):  
Liang Luo ◽  
Zheng Yi Jiang ◽  
Dong Bin Wei ◽  
Xiao Feng He
Keyword(s):  
Surface Modification ◽  
Service Life ◽  
Hybrid Methods ◽  
Biomedical Application ◽  
Medical Engineering ◽  
Biochemical Methods ◽  
Cell Tissue ◽  
Great Performance ◽  
Tissue Responses ◽  
Modification Of Titanium

Titanium and its alloys have excellent properties and are promising biomaterial in medical engineering field. A bioactive surface on a Ti substrate is a prerequisite for great performance and long service life of implants. Based on the mechanism for inducing cell/tissue responses, three kinds of methods, namely morphological, physicochemical and biochemical methods, are reviewed in this paper. Hybrid methods that integrate individual methods or have additional functions are also discussed.

Innovative surface modification of Ti6Al4V alloy by electron beam technique for biomedical application

2017 ◽  
Vol 78 ◽  
pp. 105-113 ◽  
Author(s):  
Claudia Ramskogler ◽  
Fernando Warchomicka ◽  
Sepideh Mostofi ◽  
Annelie Weinberg ◽  
Christof Sommitsch
Keyword(s):  
Surface Modification ◽  
Electron Beam ◽  
Biomedical Application ◽  
Ti6al4v Alloy ◽  
Beam Technique
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