Study of the chemical structure and the microbial effect of iron(III) metal ions with four consecutive generations of quinolones in a nanometric form for the purpose of increasing the efficacy of antibacterial and antifungal drugs

2018 ◽  
Vol 32 (3) ◽  
pp. e4195
Author(s):  
Moamen S. Refat ◽  
Mohamed Y. El‐Sayed ◽  
Reham F. Hassan
Keyword(s):  
Metal Ions ◽  
Chemical Structure ◽  
Antifungal Drugs ◽  
Antibacterial And Antifungal

FDA’s Limited Population Pathway for Antibacterial and Antifungal Drugs

2021 ◽  
Vol 109 (4) ◽  
pp. 813-815
Author(s):  
Sumathi Nambiar ◽  
Sarah Walinsky ◽  
Katherine Schumann
Keyword(s):  
Antifungal Drugs ◽  
Antibacterial And Antifungal

scholarly journals Ribosomally derived lipopeptides containing distinct fatty acyl moieties

2022 ◽  
Vol 119 (3) ◽  
pp. e2113120119
Author(s):  
Florian Hubrich ◽  
Nina M. Bösch ◽  
Clara Chepkirui ◽  
Brandon I. Morinaka ◽  
Michael Rust ◽  
...  
Keyword(s):  
Natural Products ◽  
Cyclic Peptide ◽  
Fatty Acyl ◽  
Antifungal Drugs ◽  
Guided Discovery ◽  
Bacterial Phyla ◽  
Peptide Synthetases ◽  
Antibacterial And Antifungal ◽  
Microbial Natural Products

Lipopeptides represent a large group of microbial natural products that include important antibacterial and antifungal drugs and some of the most-powerful known biosurfactants. The vast majority of lipopeptides comprise cyclic peptide backbones N-terminally equipped with various fatty acyl moieties. The known compounds of this type are biosynthesized by nonribosomal peptide synthetases, giant enzyme complexes that assemble their products in a non–gene-encoded manner. Here, we report the genome-guided discovery of ribosomally derived, fatty-acylated lipopeptides, termed selidamides. Heterologous reconstitution of three pathways, two from cyanobacteria and one from an arctic, ocean-derived alphaproteobacterium, allowed structural characterization of the probable natural products and suggest that selidamides are widespread over various bacterial phyla. The identified representatives feature cyclic peptide moieties and fatty acyl units attached to (hydroxy)ornithine or lysine side chains by maturases of the GCN5-related N-acetyltransferase superfamily. In contrast to nonribosomal lipopeptides that are usually produced as congener mixtures, the three selidamides are selectively fatty acylated with C10, C12, or C16 fatty acids, respectively. These results highlight the ability of ribosomal pathways to emulate products with diverse, nonribosomal-like features and add to the biocatalytic toolbox for peptide drug improvement and targeted discovery.

scholarly journals Photostability of triazole antifungal drugs in the solid state

2013 ◽  
Vol 26 (3) ◽  
pp. 247-251
Keyword(s):  
Solid State ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Chemical Structure ◽  
Antifungal Drugs ◽  
Densitometric Detection ◽  
Clinically Significant ◽  
Considerable Degradation ◽  
Layer Chromatography

The publication is devoted to photostability assessment of four triazole antifungal drugs: fluconazole, itraconazole, posaconazole and voriconazole. The compounds were exposed in the solid state using the whole spectrum of UV-Vis radiation. The analyses were performed using high performance thin layer chromatography (HPTLC) technique with densitometric detection. The results indicates considerable degradation of structurally similar itraconazole and posaconazole which could be clinically significant. After 72 hours of itraconazole irradiation there remain less than 25%, and 60% in case of posaconazole. To a lesser extent photodegradation concern two other compounds with a separate chemical structure: fluconazole and voriconazole. After 72 hours of irradiation there left 75% and 82% of these substances, respectively. The strict dependence between compound photostability and its chemical structure was observed.

scholarly journals Design and Development of Complexation of Ce+3 Metal Ions with Synthesized INZ Incorporated Bio-active Schiff Bases

2021 ◽  
Vol 11 (4) ◽  
pp. 3989-4006
Keyword(s):  
Schiff Base ◽  
Metal Ions ◽  
Schiff Bases ◽  
Elemental Analysis ◽  
Metal Ion ◽  
Organic Ligands ◽  
Schiff Base Complexes ◽  
Spectral Techniques ◽  
The Stability ◽  
Antibacterial And Antifungal

In the present research, a series of Ce+3 metal ions complexation with INZ incorporating Schiff bases have been reported. INZ incorporated Schiff Bases (3a-e) were developed by condensing INZ with substituted aromatic aldehyde and confirmed with various spectral Techniques such as Elemental analysis, UV, IR, 1H-NMR, 13H NMR. All the synthesized organic ligands were evaluated against antibacterial and antifungal stains and found moderate to significant results. The Ce+3 metal ion solution mixed with newly prepared bio-active INZ Schiff bases (3a-e) to afford the [Ce-INZ Schiff Base] complexes (4a-e). The stability constants of prepared complexes were evaluated and found in order as a (3e) > (3d) > (3a) > (3b) > (3c).

scholarly journals Synthesis, Molecular Docking and Evaluation of Library of 3-Mercapto-1,2,4-Triazole Derivatives as Antimicrobial Agents

2021 ◽  
Vol 33 (12) ◽  
pp. 3039-3046
Author(s):  
Swarnagowri Nayak ◽  
Santosh L. Gaonkar ◽  
Sushruta S. Hakkimane ◽  
Swapna B ◽  
Nitinkumar S. Shetty
Keyword(s):  
Antimicrobial Activity ◽  
Molecular Docking ◽  
In Silico ◽  
Structural Modification ◽  
Antimicrobial Agents ◽  
Antifungal Drugs ◽  
Aromatic Acids ◽  
Triazole Derivatives ◽  
In Silico Study ◽  
Antibacterial And Antifungal

Due to the increasing microbial resistance to antibacterial and antifungal drugs, the development of new antimicrobial agents is an urgent priority. In search of newer antimicrobial agents, a series of 4,5-disubstituted-3-mercapto-1,2,4-triazole derivatives were synthesized from aromatic acids and substituted isothiocyanates. The in silico study was performed to study the binding interactions of the synthesized compounds with the active pocket of CYP51. Among the synthesized 3-mercapto-triazole derivatives, compounds 6r, 6s and 6u exhibited promising antimicrobial activity comparable to standard drugs. The results suggested that the structural modification to 3-mercapto-1,2,4-triazole derivatives could lead to promising antimicrobial scaffolds.

Triumvirate to treat mucormycosis: Interplay of pH, metal ions and antifungal drugs

2022 ◽  
pp. 110748
Author(s):  
Bhupinder Kapoor ◽  
Rajpal Singh Kochhar ◽  
Monica Gulati ◽  
Pooja Rani ◽  
Reena Gupta ◽  
...  
Keyword(s):  
Metal Ions ◽  
Antifungal Drugs

scholarly journals Clinical practice of managing corneal ulcer of unknown etiology with pro-tracted course in presence of toxic and allergic component

2021 ◽  
pp. 58-65
Author(s):  
D.Y. Maychuk ◽  
◽  
A. A. Tarkhanova ◽  
A.O. Loshkareva ◽  
I. A. Drozdkov ◽  
...  
Keyword(s):  
Allergic Reaction ◽  
Corneal Ulcer ◽  
Positive Response ◽  
Antifungal Drugs ◽  
Response To Treatment ◽  
Unknown Etiology ◽  
The Subject ◽  
Long Term Observation ◽  
Antibacterial And Antifungal

Purpose. The representation of the clinical case of corneal ulcer course with unknown etiology in presence of patient's acute toxic and allergic reaction. The patient was under long-term observation of the local ophthalmologist and didn't show positive response to treatment. Material and methods. Patient examination on the date of his encounter sug-gested bacterial etiology of the process. However, the etiological factor wasn't re-vealed by laboratory tests. The presence of toxic and allergic components in biomi-croscopy of both eyes, long-term prestudy antibacterial therapy, character of corneal ulcer gave rise to prescription of the therapy. Results. The main areas of the therapy are allergy medications, antibacterial and antifungal drugs. The positive response in the disease course allowed us to be-lieve that the treatment was accurately prescribed Conclusion. Protracted course of the corneal ulcer without positive response is the subject to estimate the presence of toxic and allergic components. Considering the duration of the disease the antifungal drugs were prescribed at the beginning of the therapy, in spite of the assumption that bacterial etiology of the process may take place. Keywords: corneal ulcer, toxic and allergic reaction.

scholarly journals Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on Lisinopril

2017 ◽  
Vol 58 (2) ◽  
Author(s):  
M. Zaky ◽  
Mohamed Y. El-Sayed ◽  
Samy M. El-Megharbel ◽  
Sameh Abo Taleb ◽  
Moamen S. Refat
Keyword(s):  
Oxygen Atom ◽  
Metal Ions ◽  
Thermodynamic Parameters ◽  
Structure Elucidation ◽  
Chemical Structure ◽  
Carboxylate Oxygen Atom ◽  
Carboxylate Oxygen ◽  
Biological Studies ◽  
Bacteria And Fungi

<p>Complexes of lisinopril as a pharmaceutical ligand with Ca(II), Mg(II), Zn(II), Fe(III) and VO(II), were synthesized and characterized by microanalysis, conductance, infrared and thermogravimetric (TGA/DTG and DTA) measurements. The lisinopril ligand acts as a monodentate feature via one carboxylate oxygen atom. Lisinopril and their complexes have been checked against some kinds of bacteria and fungi which gave a significant effect. The kinetic thermodynamic parameters such as: activation of E*, ΔH*, ΔS* and ΔG* were estimated using Coats and Redfern as well as Horowitz-Metzger equations.</p>

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