Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on Lisinopril

<p>Complexes of lisinopril as a pharmaceutical ligand with Ca(II), Mg(II), Zn(II), Fe(III) and VO(II), were synthesized and characterized by microanalysis, conductance, infrared and thermogravimetric (TGA/DTG and DTA) measurements. The lisinopril ligand acts as a monodentate feature via one carboxylate oxygen atom. Lisinopril and their complexes have been checked against some kinds of bacteria and fungi which gave a significant effect. The kinetic thermodynamic parameters such as: activation of E*, ΔH*, ΔS* and ΔG* were estimated using Coats and Redfern as well as Horowitz-Metzger equations.</p>

Metallkomplexe mit biologisch wichtigen Liganden, L [1] Palladium(II)-, Platin(II)- und Kupfer(II)-Komplexe von α-Aminosäure-N-Glykosiden und von Fructose-Aminosäuren (Amadori-Verbindungen) / Metal Complexes of Biologically Important Ligands, L [1] Palladium(II), Platinum(II) and Copper(II) Complexes of α-Amino Acid-N-Glycosides and of Fructose-Amino Acids (Amadori-Compounds)

Various N-glycosides derived from glucose and α-amino acids and the isomeric Amadori compounds form bis(chelate) complexes of copper(II), palladium (II) and platinum (II). The IR spectra indicate that the ligands are coordinated through the amino group and a carboxylate oxygen atom.