Catalytic Asymmetric Tandem Reaction of Tertiary Enamides: Expeditious Synthesis of Pyrrolo[2,1-a ]isoquinoline Alkaloid Derivatives

2016 ◽  
Vol 55 (11) ◽  
pp. 3799-3803 ◽  
Author(s):  
Xin-Ming Xu ◽  
Liang Zhao ◽  
Jieping Zhu ◽  
Mei-Xiang Wang
Keyword(s):  
Isoquinoline Alkaloid ◽  
Tandem Reaction ◽  
Catalytic Asymmetric

Catalytic Asymmetric Tandem Reaction of o-Alkynylbenzaldehydes, Amines, and Diazo Compounds

2021 ◽  
Author(s):  
Wei Wu ◽  
Na Liao ◽  
Qi Wei ◽  
Jiaying Huang ◽  
Qi Huang ◽  
...  
Keyword(s):  
Diazo Compounds ◽  
Tandem Reaction ◽  
Catalytic Asymmetric

Catalytic asymmetric trifluoromethylthiolation of carbonyl compounds via a diastereo and enantioselective Cu-catalyzed tandem reaction

2018 ◽  
Vol 54 (36) ◽  
pp. 4581-4584 ◽  
Author(s):  
Ming Yu Jin ◽  
Juncheng Li ◽  
Renke Huang ◽  
Yuxuan Zhou ◽  
Lung Wa Chung ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Tandem Reaction ◽  
Catalytic Asymmetric

The tandem reaction realizes the asymmetric integration of –SCF3 group to carbonyl compounds, establishing the chiral tertiary α-carbon center and affording the α-SCF3-β-substituted carbonyl compounds in 50–92% yields with up to 20 : 1 dr and 96% ee.

Bimetallic Catalytic Asymmetric Tandem Reaction of β‐Alkynyl Ketones to Synthesize 6,6‐Spiroketals

2019 ◽  
Vol 58 (12) ◽  
pp. 4017-4021 ◽  
Author(s):  
Shulin Ge ◽  
Weidi Cao ◽  
Tengfei Kang ◽  
Bowen Hu ◽  
Hang Zhang ◽  
...  
Keyword(s):  
Tandem Reaction ◽  
Catalytic Asymmetric

Bimetallic Catalytic Asymmetric Tandem Reaction of β‐Alkynyl Ketones to Synthesize 6,6‐Spiroketals

2019 ◽  
Vol 131 (12) ◽  
pp. 4057-4061 ◽  
Author(s):  
Shulin Ge ◽  
Weidi Cao ◽  
Tengfei Kang ◽  
Bowen Hu ◽  
Hang Zhang ◽  
...  
Keyword(s):  
Tandem Reaction ◽  
Catalytic Asymmetric

scholarly journals Catalytic asymmetric tandem Friedel–Crafts alkylation/Michael addition reaction for the synthesis of highly functionalized chromans

2013 ◽  
Vol 9 ◽  
pp. 1210-1216 ◽  
Author(s):  
Jiahuan Peng ◽  
Da-Ming Du
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Tandem Reaction ◽  
Michael Addition Reaction ◽  
Catalytic Asymmetric

The enantioselective tandem Friedel–Crafts alkylation/Michael addition reaction of indoles with nitroolefin enoates catalyzed by a diphenylamine-linked bis(oxazoline)-Zn(OTf)2 complex was investigated. This tandem reaction afforded functionalized chiral chromans in good yields with moderate to high stereoselectivities (up to 95:5 dr, up to 99% ee).

Catalytic enantioselective synthesis of indolizino[8,7-b]indole alkaloid derivatives based on the tandem reaction of tertiary enamides

2021 ◽  
Author(s):  
Xin-Ming Xu ◽  
Ming Xie ◽  
Jiazhu Li ◽  
Mei-Xiang Wang
Keyword(s):  
Indole Alkaloid ◽  
Enantioselective Synthesis ◽  
High Yield ◽  
Tandem Reaction ◽  
Indole Derivatives

An exquisite Pybox/Cu(OTf)2-catalyzed asymmetric tandem reaction of tertiary enamides was developed, which enabled the expeditious synthesis of indolizino[8,7-b]indole derivatives in high yield, excellent enantioselectivity and diastereoselectivity.

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