Catalytic asymmetric trifluoromethylthiolation of carbonyl compounds via a diastereo and enantioselective Cu-catalyzed tandem reaction

2018 ◽  
Vol 54 (36) ◽  
pp. 4581-4584 ◽  
Author(s):  
Ming Yu Jin ◽  
Juncheng Li ◽  
Renke Huang ◽  
Yuxuan Zhou ◽  
Lung Wa Chung ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Tandem Reaction ◽  
Catalytic Asymmetric

The tandem reaction realizes the asymmetric integration of –SCF3 group to carbonyl compounds, establishing the chiral tertiary α-carbon center and affording the α-SCF3-β-substituted carbonyl compounds in 50–92% yields with up to 20 : 1 dr and 96% ee.

Catalytic Asymmetric Tandem Reaction of o-Alkynylbenzaldehydes, Amines, and Diazo Compounds

2021 ◽  
Author(s):  
Wei Wu ◽  
Na Liao ◽  
Qi Wei ◽  
Jiaying Huang ◽  
Qi Huang ◽  
...  
Keyword(s):  
Diazo Compounds ◽  
Tandem Reaction ◽  
Catalytic Asymmetric

Catalytic asymmetric enamine protonation reaction

2018 ◽  
Vol 16 (4) ◽  
pp. 510-520 ◽  
Author(s):  
Niankai Fu ◽  
Long Zhang ◽  
Sanzhong Luo
Keyword(s):  
Carbonyl Compounds ◽  
Optically Active ◽  
Protonation Reaction ◽  
Recent Advances ◽  
Catalytic Asymmetric

Recent advances in catalytic enantioselective enamine protonation for the synthesis of optically active carbonyl compounds are summarized in this review.

scholarly journals Recent Developments and Applications of the Chiral Brønsted Acid Catalyzed Allylboration of Carbonyl Compounds

Synthesis ◽  
2018 ◽  
Vol 50 (10) ◽  
pp. 1935-1957 ◽  
Author(s):  
Daniel Sedgwick ◽  
Matthew Grayson ◽  
Santos Fustero ◽  
Pablo Barrio
Keyword(s):  
Carbonyl Compounds ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
The Past ◽  
Homoallylic Alcohols ◽  
Brönsted Acid ◽  
Recent Developments ◽  
Acid Catalyzed ◽  
Catalytic Asymmetric ◽  
Chiral Bronsted Acid

The 50-year-old allylboration reaction has seen dramatic developments since the dawn of the new century after the first catalytic asymmetric versions came into play. In the past decade alone, several methodologies capable of achieving the desired homoallylic alcohols in over 90% ee have been developed. This review focuses on the chiral Brønsted acid catalyzed allylboration reaction, covering everything from the very first examples and precedents to modern day variations and applications.1 Introduction2 Early Developments3 Synthetic Applications4 Variants5 Computational Contribution6 Conclusions

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