Catalytic Asymmetric Five-Component Tandem Reaction: Diastereo- and Enantioselective Synthesis of Densely Functionalized Tetrahydropyridines with Biological Importance

2013 ◽  
Vol 355 (8) ◽  
pp. 1605-1622 ◽  
Author(s):  
Feng Shi ◽  
Wei Tan ◽  
Ren-Yi Zhu ◽  
Gui-Juan Xing ◽  
Shu-Jiang Tu
Author(s):  
Xin-Ming Xu ◽  
Ming Xie ◽  
Jiazhu Li ◽  
Mei-Xiang Wang

An exquisite Pybox/Cu(OTf)2-catalyzed asymmetric tandem reaction of tertiary enamides was developed, which enabled the expeditious synthesis of indolizino[8,7-b]indole derivatives in high yield, excellent enantioselectivity and diastereoselectivity.


2021 ◽  
Author(s):  
Mengxue Lu ◽  
Zongli Xiong ◽  
Yuqiao Zhou ◽  
Xin Wang ◽  
Xiaoyi Li ◽  
...  

The enantioselective synthesis of fluorinated tricyclic chromanones with multiple vicinal stereogenic centers has been realized for the first time, through the tandem reaction between 2-fluorinated 1-(2-hydroxyaryl)-1,3-diketones and α,β-unsaturated aldehydes. In...


2016 ◽  
Vol 14 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Allegra Franchino ◽  
Pavol Jakubec ◽  
Darren J. Dixon

A concise synthesis of (−)-chloramphenicol, based on the catalytic asymmetric aldol reaction between 4-nitrobenzaldehyde and benzhydryl isocyanoacetate, is reported.


2021 ◽  
Author(s):  
Wei Wu ◽  
Na Liao ◽  
Qi Wei ◽  
Jiaying Huang ◽  
Qi Huang ◽  
...  

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