scholarly journals Studies on the syntheses of heterocyclic compounds and natural products. CMXCII. Synthesis of an A-homograyanotoxane and a phyllocladane ring system from a common precursor.

1983 ◽  
Vol 31 (1) ◽  
pp. 57-63 ◽  
Author(s):  
KOZO SHISHIDO ◽  
TAKAHIRO MATSUURA ◽  
KEIICHIRO FUKUMOTO ◽  
TETSUJI KAMETANI
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Ring System ◽  
Common Precursor

Synthesis of Spongidine A, D and Petrosaspongiolide L Methyl Ester Using Pyridine C-H Functionalization

2019 ◽  
Author(s):  
Florian Bartels ◽  
Manuela Weber ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Methyl Ester ◽  
Hydrogen Atom ◽  
Phospholipase A2 ◽  
Late Stage ◽  
Hydrogen Atom Transfer ◽  
Ring System ◽  
Tetracyclic Core ◽  
Intramolecular Hydrogen ◽  
Phospholipase A2 Inhibitors

<div>An efficient strategy for the synthesis of the potent phospholipase A2 inhibitors spongidine A and D is presented. The tetracyclic core of the natural products was assembled via an intramolecular hydrogen atom transfer‐initiated Minisci reaction. A divergent late‐stage functionalization of the tetracyclic ring system was also used to achieve a concise synthesis of petrosaspongiolide L methyl ester.</div>

Heterocyclic compounds. XVI . Chemistry of the 1,4,2,3,5,6-dithiatetrazine ring system

1979 ◽  
Vol 16 (4) ◽  
pp. 751-752 ◽  
Author(s):  
Boris Weinstein ◽  
Louis T. Hahn ◽  
Alvin K. Eng
Keyword(s):  
Heterocyclic Compounds ◽  
Ring System

Research Progress of N-Alkylation of Alcohol and Amine by "Hydrogen Reaction"

2021 ◽  
Vol 871 ◽  
pp. 312-317
Author(s):  
Si Min Feng ◽  
Qing Liu
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Amino Alcohols ◽  
New Method ◽  
Research Progress ◽  
Primary Alcohols ◽  
Ammonia Gas ◽  
Fine Chemical ◽  
Chemical Products ◽  
Amine Compounds

Amine compounds are widely found in natural products, pharmaceuticals and fine chemical products. Therefore, it is of great significance to develop methods for synthesizing amine compounds. Therefore, in recent years, a new method of synthesizing amines has been developed, namely "hydrogen borrowing reaction". This article reviews the alkylation of primary alcohols and amines, the cyclization of amino alcohols to form N-heterocyclic compounds, the reaction of diols and amines to form N-heterocyclic compounds, the reaction of alcohols and sulfonamides, and the reaction of alcohols and amines containing N heteroatoms , Alcohol and ammonia gas and ammonia to produce amine by hydrogen reaction research progress.

scholarly journals Expedient Access to Enantiopure Cyclopentanic Natural Products: Total Synthesis of (-)-Cyclonerodiol

2015 ◽  
Vol 10 (1) ◽  
pp. 1934578X1501000
Author(s):  
Carmen Pérez Morales ◽  
M. Mar Herrador ◽  
José F. Quílez del Moral ◽  
Alejandro F. Barrero
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Radical Cyclization ◽  
Formal Synthesis ◽  
Common Precursor ◽  
Enantiospecific Synthesis ◽  
Optically Pure

Following the principles of collective total synthesis, a number of natural products sharing an optically pure, multifunctional, cyclopentanic core were synthesized from a common precursor: plinol A (1). This intermediate was efficiently obtained in only four steps from (-)-linalool (2) using as the key step a Ti(III)-mediated diastereoselective radical cyclization. The feasibility of this approach was confirmed with the expedient enantiospecific synthesis of cyclonerodiol (3), and the formal synthesis of chocol G (4) and piperitone (5).

Talaronoids A–D: four fusicoccane diterpenoids with an unprecedented tricyclic 5/8/6 ring system from the fungus Talaromyces stipitatus

2020 ◽  
Vol 7 (21) ◽  
pp. 3486-3492
Author(s):  
Mi Zhang ◽  
Shan Yan ◽  
Yu Liang ◽  
Meijia Zheng ◽  
Zhaodi Wu ◽  
...  
Keyword(s):  
Natural Products ◽  
Ring System ◽  
Carbon Skeleton

Talaronoids A–D (1–4), four fusicoccane diterpenoids with an unexpected tricyclic 5/8/6 carbon skeleton from Talaromyces stipitatus, represent the first examples of natural products with a benzo[a]cyclopenta[d]cyclooctane skeleton.

scholarly journals Two decades of recent advances of Ugi reactions: synthetic and pharmaceutical applications

RSC Advances ◽  
2020 ◽  
Vol 10 (70) ◽  
pp. 42644-42681
Author(s):  
Manar Ahmed Fouad ◽  
Hamida Abdel-Hamid ◽  
Mohammed Salah Ayoup
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Cyclic Peptides ◽  
Ugi Reaction ◽  
Pharmaceutical Applications ◽  
Recent Advances

We highlight the recent advances of the Ugi reaction in the last two decades from 2000–2019, mainly in the synthesis of linear or cyclic peptides, heterocyclic compounds with versatile ring sizes, and natural products, as well as the enantioselective Ugi reactions.

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