MiRNA Delivery System Based on Stimuli-Responsive Gold Nanoparticle Aggregates for Multimodal Tumor Therapy

2019 ◽  
Vol 2 (7) ◽  
pp. 2833-2839 ◽  
Author(s):  
Xiangdong Wang ◽  
Nuo Jin ◽  
Qiao Wang ◽  
Tao Liu ◽  
Kangcan Liu ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Delivery System ◽  
Tumor Therapy ◽  
Stimuli Responsive ◽  
Nanoparticle Aggregates

Preparation of controlled gold nanoparticle aggregates using a dendronization strategy

2012 ◽  
Vol 384 (1) ◽  
pp. 10-21 ◽  
Author(s):  
Julieta I. Paez ◽  
Eduardo A. Coronado ◽  
Miriam C. Strumia
Keyword(s):  
Gold Nanoparticle ◽  
Nanoparticle Aggregates

scholarly journals Environment Responsive Metal–Organic Frameworks as Drug Delivery System for Tumor Therapy

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Chao Yan ◽  
Yue Jin ◽  
Chuanxiang Zhao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Metal Organic Frameworks ◽  
Delivery Systems ◽  
Drug Uptake ◽  
High Concentration ◽  
Metal Organic

AbstractNanoparticles as drug delivery systems can alter the drugs' hydrophilicity to affect drug uptake and efflux in tissues. They prevent drugs from non-specifically binding with bio-macromolecules and enhance drug accumulation at the lesion sites, improving therapy effects and reducing unnecessary side effects. Metal–organic frameworks (MOFs), the typical nanoparticles, a class of crystalline porous materials via self-assembled organic linkers and metal ions, exhibit excellent biodegradability, pore shape and sizes, and finely tunable chemical composition. MOFs have a rigid molecular structure, and tunable pore size can improve the encapsulation drug's stability under harsh conditions. Besides, the surface of MOFs can be modified with small-molecule ligands and biomolecule, and binding with the biomarkers which is overexpressed on the surface of cancer cells. MOFs formulations for therapeutic have been developed to effectively respond to the unique tumor microenvironment (TEM), such as high H2O2 levels, hypoxia, and high concentration glutathione (GSH). Thus, MOFs as a drug delivery system should avoid drugs leaking during blood circulation and releasing at the lesion sites via a controlling manner. In this article, we will summary environment responsive MOFs as drug delivery systems for tumor therapy under different stimuli.

Schiff base-containing dextran nanogel as pH-sensitive drug delivery system of doxorubicin: Synthesis and characterization

2018 ◽  
Vol 33 (2) ◽  
pp. 170-181 ◽  
Author(s):  
Hongying Su ◽  
Wen Zhang ◽  
Yayun Wu ◽  
Xiaodong Han ◽  
Gang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Cell Uptake ◽  
Stimuli Responsive ◽  
Drug Release Profile

Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. Approximately 66, 28, and 9% of drug was released in 72 h at pH 2.0, 5.0, and 7.4, respectively. Cell uptake by the human breast cancer cell (MCF-7) demonstrated that the DOX-loaded dextran nanogel could be internalized through endocytosis and distributed in endocytic compartments inside tumor cells. These results indicated that the Schiff base-containing nanogel can serve as a pH-sensitive drug delivery system. And the presence of multiple aldehyde groups on the nanogel are available for further conjugations of targeting ligands or imaging probes.

Dynamic motions and architectural changes in DNA supramolecular aggregates visualized via transmission electron microscopy without liquid cells

Nanoscale ◽  
2021 ◽  
Vol 13 (37) ◽  
pp. 15928-15936
Author(s):  
Zhuoyang Lu ◽  
Xiangyang Liu ◽  
Maogang He ◽  
Jiangang Long ◽  
Jiankang Liu
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Ionic Liquids ◽  
Gold Nanoparticle ◽  
Dynamic Processes ◽  
Nanometer Resolution ◽  
Transmission Electron ◽  
Nanoparticle Aggregates ◽  
Supramolecular Aggregates

The nonvolatility and remarkable solvation property of ionic liquids is exploited to image the dynamic processes of DNA supramolecular aggregates and gold nanoparticle aggregates at nanometer resolution in an unsealed manner.

Dual-responsive polyphosphazene as a common platform for highly efficient drug self-delivery

2019 ◽  
Vol 7 (27) ◽  
pp. 4319-4327 ◽  
Author(s):  
Sheng-Lei Hou ◽  
Shuang-Shuang Chen ◽  
Zhang-Jun Huang ◽  
Qing-Hua Lu
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Cancer Chemotherapy ◽  
Stimuli Responsive ◽  
Highly Efficient ◽  
Dual Responsive ◽  
Common Platform

A drug self-framed delivery system (DSFDS) with dual-stimuli-responsive drug release and superhigh drug loaded capacity for efficient cancer chemotherapy is proposed.

Metabolizable dopamine-coated gold nanoparticle aggregates: preparation, characteristics, computed tomography imaging, acute toxicity, and metabolism in vivo

2016 ◽  
Vol 4 (6) ◽  
pp. 1090-1099 ◽  
Author(s):  
Yao Yu ◽  
Youshen Wu ◽  
Jiajun Liu ◽  
Ke Li ◽  
Daocheng Wu
Keyword(s):  
Computed Tomography ◽  
Acute Toxicity ◽  
Gold Nanoparticle ◽  
Circulation Time ◽  
Computed Tomography Imaging ◽  
Lower Toxicity ◽  
Tomography Imaging ◽  
Imaging Results ◽  
Nanoparticle Aggregates

We prepared metabolizable MSA AuNPs@DPA aggregates, which exhibit improved CT imaging results, much lower toxicity and much longer circulation time in vivo.

An intelligent dual stimuli-responsive photosensitizer delivery system with O2-supplying for efficient photodynamic therapy

2018 ◽  
Vol 167 ◽  
pp. 299-309 ◽  
Author(s):  
Hongjuan Zhao ◽  
Li Li ◽  
Cuixia Zheng ◽  
Yongwei Hao ◽  
Mengya Niu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Delivery System ◽  
Stimuli Responsive
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