scholarly journals Time‐Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE‐Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation

2019 ◽  
Vol 132 (24) ◽  
pp. 9557-9564 ◽  
Author(s):  
Qiyao Li ◽  
Ying Li ◽  
Tianliang Min ◽  
Junyi Gong ◽  
Lili Du ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Time Dependent ◽  
Multiple Targets ◽  
Highly Efficient ◽  
Cell Ablation

scholarly journals Pyridinium-substituted tetraphenylethylene salt-based photosensitizers by varying counter anions: a highly efficient photodynamic therapy for cancer cell ablation and bacterial inactivation

2020 ◽  
Vol 8 (24) ◽  
pp. 5234-5244 ◽  
Author(s):  
Wei Xiong ◽  
Lingyun Wang ◽  
Xiaoli Chen ◽  
Hao Tang ◽  
Derong Cao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Bacterial Inactivation ◽  
Highly Efficient ◽  
Cell Ablation ◽  
Photodynamic Therapy Of Cancer

A highly efficient photodynamic therapy of cancer cell ablation and bacterial inactivation by two AIEgens was reported.

scholarly journals Time-dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE-active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation

2019 ◽  
Author(s):  
Qiyao Li ◽  
Ying Li ◽  
Tianliang Min ◽  
Junyi Gong ◽  
Lili Du ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Reactive Oxygen Species Generation ◽  
Emission Feature ◽  
Time Dependent ◽  
Organic Salt ◽  
Antibacterial Performance ◽  
Cell Ablation ◽  
External Conditions

Pathogen infection and cancer are the two major human health problems. In this work, we achieved an organic salt photosensitizer (PS), called 4TPA-BQ with aggregation-induced emission feature <i>via</i> one-step reaction. Owing to the aggregation-induced reactive oxygen species generation effect and sufficient small ΔE<sub>ST</sub>, 4TPA-BQ shows a satisfactorily high <sup>1</sup>O<sub>2</sub> generation efficiency of 97.8%. <i>In vitro</i> and <i>in vivo</i> experiments confirmed that 4TPA-BQ exhibited potent photodynamic antibacterial performance against ampicillin-resistant <i>Escherichia coli</i> with good biocompatibility in a short time (15 min). When the incubation time persisted long enough (12 h), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time-dependent fluorescence-guided photodynamic therapy in one individual PS for ordered and multiple targeting by varying the external conditions. This can update the design principle of efficient PSs in potential clinical applications.

Dual-targeted activatable photosensitizers with aggregation-induced emission (AIE) characteristics for image-guided photodynamic cancer cell ablation

2016 ◽  
Vol 4 (1) ◽  
pp. 169-176 ◽  
Author(s):  
Youyong Yuan ◽  
Shidang Xu ◽  
Chong-Jing Zhang ◽  
Ruoyu Zhang ◽  
Bin Liu
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Normal Cell ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
Cell Ablation

The currently available photosensitizers (PSs) for photodynamic therapy (PDT) can easily lead to undesirable normal cell death due to their intrinsic photo-toxicity and lack of selectivity for cancer cells.

scholarly journals Time-dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE-active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation

2019 ◽  
Author(s):  
Qiyao Li ◽  
Ying Li ◽  
Tianliang Min ◽  
Junyi Gong ◽  
Lili Du ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Reactive Oxygen Species Generation ◽  
Emission Feature ◽  
Time Dependent ◽  
Organic Salt ◽  
Antibacterial Performance ◽  
Cell Ablation ◽  
External Conditions

Pathogen infection and cancer are the two major human health problems. In this work, we achieved an organic salt photosensitizer (PS), called 4TPA-BQ with aggregation-induced emission feature <i>via</i> one-step reaction. Owing to the aggregation-induced reactive oxygen species generation effect and sufficient small ΔE<sub>ST</sub>, 4TPA-BQ shows a satisfactorily high <sup>1</sup>O<sub>2</sub> generation efficiency of 97.8%. <i>In vitro</i> and <i>in vivo</i> experiments confirmed that 4TPA-BQ exhibited potent photodynamic antibacterial performance against ampicillin-resistant <i>Escherichia coli</i> with good biocompatibility in a short time (15 min). When the incubation time persisted long enough (12 h), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time-dependent fluorescence-guided photodynamic therapy in one individual PS for ordered and multiple targeting by varying the external conditions. This can update the design principle of efficient PSs in potential clinical applications.

Hydrogen peroxide-responsive AIE probe for imaging-guided organelle targeting and photodynamic cancer cell ablation

2021 ◽  
Author(s):  
Qian Wu ◽  
Youmei Li ◽  
Ying Li ◽  
Dong Wang ◽  
Ben Zhong Tang
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Cell Ablation ◽  
Selective Monitoring ◽  
Organelle Targeting

Hydrogen peroxide (H2O2), as one kind of key reactive oxygen species (ROS), is mainly produced endogenously primarily in the mitochondria. The selective monitoring of H2O2 in living cells is of...

scholarly journals Biomimetic oxygen delivery nanoparticles for enhancing photodynamic therapy in triple-negative breast cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hanyi Fang ◽  
Yongkang Gai ◽  
Sheng Wang ◽  
Qingyao Liu ◽  
Xiao Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Oxygen Delivery ◽  
Therapeutic Efficacy ◽  
Triple Negative ◽  
Oxygen Solubility ◽  
Post Injection

Abstract Background Triple-negative breast cancer (TNBC) is a kind of aggressive breast cancer with a high rate of metastasis, poor overall survival time, and a low response to targeted therapies. To improve the therapeutic efficacy and overcome the drug resistance of TNBC treatments, here we developed the cancer cell membrane-coated oxygen delivery nanoprobe, CCm–HSA–ICG–PFTBA, which can improve the hypoxia at tumor sites and enhance the therapeutic efficacy of the photodynamic therapy (PDT), resulting in relieving the tumor growth in TNBC xenografts. Results The size of the CCm–HSA–ICG–PFTBA was 131.3 ± 1.08 nm. The in vitro 1O2 and ROS concentrations of the CCm–HSA–ICG–PFTBA group were both significantly higher than those of the other groups (P < 0.001). In vivo fluorescence imaging revealed that the best time window was at 24 h post-injection of the CCm–HSA–ICG–PFTBA. Both in vivo 18F-FMISO PET imaging and ex vivo immunofluorescence staining results exhibited that the tumor hypoxia was significantly improved at 24 h post-injection of the CCm–HSA–ICG–PFTBA. For in vivo PDT treatment, the tumor volume and weight of the CCm–HSA–ICG–PFTBA with NIR group were both the smallest among all the groups and significantly decreased compared to the untreated group (P < 0.01). No obvious biotoxicity was observed by the injection of CCm–HSA–ICG–PFTBA till 14 days. Conclusions By using the high oxygen solubility of perfluorocarbon (PFC) and the homologous targeting ability of cancer cell membranes, CCm–HSA–ICG–PFTBA can target tumor tissues, mitigate the hypoxia of the tumor microenvironment, and enhance the PDT efficacy in TNBC xenografts. Furthermore, the HSA, ICG, and PFC are all FDA-approved materials, which render the nanoparticles highly biocompatible and enhance the potential for clinical translation in the treatment of TNBC patients.

Photodynamic therapy in a cervico-uterine cancer cell line (HeLa) implanted in nu/nu mice

2001 ◽  
Author(s):  
Eva Ramon Gallegos ◽  
Salomon Hernandez Guitierrez ◽  
Leticia Garduno Siciliano ◽  
Jose L. Jiminez Perez ◽  
Aura J. Perez Zapata ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Line ◽  
Cancer Cell ◽  
Uterine Cancer ◽  
Cancer Cell Line ◽  
Cell Line Hela ◽  
Line Hela
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