Photodynamic therapy in a cervico-uterine cancer cell line (HeLa) implanted in nu/nu mice

2001 ◽  
Author(s):  
Eva Ramon Gallegos ◽  
Salomon Hernandez Guitierrez ◽  
Leticia Garduno Siciliano ◽  
Jose L. Jiminez Perez ◽  
Aura J. Perez Zapata ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cell Line ◽  
Cancer Cell ◽  
Uterine Cancer ◽  
Cancer Cell Line ◽  
Cell Line Hela ◽  
Line Hela

scholarly journals The restraining effect of baicalein and U0126 on human cervical cancer cell line HeLa

2017 ◽  
Vol 16 (1) ◽  
pp. 957-963 ◽  
Author(s):  
Haiqiong Ye ◽  
Yujiao Zhang ◽  
Yongzhou Wang ◽  
Jiyi Xia ◽  
Xiguang Mao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Human Cervical Cancer Cell ◽  
Line Hela ◽  
Human Cervical Cancer

scholarly journals Caspase-mediated apoptotic effects of Ebenus boissieri barbey extracts on human cervical cancer cell line hela

2017 ◽  
Vol 13 (50) ◽  
pp. 254 ◽  
Author(s):  
Ece Simsek ◽  
Nilufer Imir ◽  
EsraArslan Aydemir ◽  
RamazanSuleyman Gokturk ◽  
Erdem Yesilada ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Human Cervical Cancer Cell ◽  
Apoptotic Effects ◽  
Line Hela ◽  
Human Cervical Cancer

Fucoxanthin induces apoptosis in human cervical cancer cell line HeLa via PI3K/Akt pathway

Tumor Biology ◽  
2014 ◽  
Vol 35 (11) ◽  
pp. 11261-11267 ◽  
Author(s):  
Guoliu Ye ◽  
Qin Lu ◽  
Weidong Zhao ◽  
Danli Du ◽  
Lijie Jin ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Akt Pathway ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Human Cervical Cancer Cell ◽  
Line Hela ◽  
Human Cervical Cancer

scholarly journals The effect of Chaihu-shugan-san on cytotoxicity induction and PDGF gene expression in cervical cancer cell line HeLa in the presence of paclitaxel +cisplatin

2021 ◽  
Vol 67 (3) ◽  
pp. 143-147
Author(s):  
Xue Jianfang ◽  
Zhu Ling ◽  
Jiao Yanan ◽  
Guan Yanliang
Keyword(s):  
Gene Expression ◽  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Significant Difference ◽  
Line Hela

Chaihu-shugan-san, as a traditional Chinese herbal formula, is composed of seven different herbs. This medicine can treat cancer due to its antioxidant compounds. In this study, the effect of Chaihu-shugan-san was considered on cytotoxicity induction and PDGF gene expression in cervical cancer cell line HeLa at different concentrations and at different times, by the MTT method. Paclitaxel + cisplatin were used as a control in this study. The expression of the PDGF gene was quantitatively evaluated in treated cells by real-time PCR, and a generalized linear model was used to evaluate the effect of the medicine, and Duncan's multiple range tests were used to evaluate the data. The results of the MTT test showed that Chaihu-shugan-san had antitumor properties in different concentrations, but there was a significant difference between this medicine and paclitaxel +cisplatin. Also, examination of gene expression showed that this medicine reduced the expression of the PDGF gene in the HeLa cancer cell line (P ? 0.04). Therefore, Chaihu-shugan-san could be suggested as an effective factor in preventing the growth of cervical cancer cells and controlling angiogenic factors that play an important role in the metastasis of cancerous tumors.

Chemical Constituents and Cytotoxicity of Euphorbia vajravelui

2019 ◽  
Vol 16 (8) ◽  
pp. 643-646
Author(s):  
Vijayalekshmi Anju ◽  
Sulochana Priya ◽  
Sabulal Baby ◽  
Koranappallil Bahuleyan Rameshkumar
Keyword(s):  
Single Crystal ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell Line ◽  
Single Crystal Xrd ◽  
Cytotoxicity Studies ◽  
Cell Line Hela ◽  
Cardiac Myoblasts ◽  
Line Hela

Euphorbia species are important in traditional medicines as well as in horticulture. Though 82 Euphorbia species are reported from India, most of the species are yet to be explored for the phytochemicals or bioactivities. The present study reports the phytochemical and cytotoxicity studies of the Western Ghats endemic plant Euphorbia vajravelui. Compounds were isolated from the extracts of E. vajravelui using column chromatography and were characterized through various spectroscopic techniques. The structures were further confirmed through single crystal XRD. The major pentacyclic triterpene 3β-friedelinol was estimated using a validated HPTLC method. Cytotoxicity of the extracts was tested against human cervical cancer cell line HeLa and normal cardiac myoblasts cell line H9C2 using MTT assay. The pentacyclic triterpenoids taraxeryl acetate, epi-friedelinyl acetate, 3β-friedelinol, taraxerol, 3α-friedelinol and friedelane-2β,3α-diyl diacetate and the phenolic compound 3,4,3'-tri-Omethyl ellagic acid 4'-rutinoside were isolated and characterized from E. vajravelui. Single crystal XRD data of epi-friedelinyl acetate, taraxerol and 3α-friedelinol were also reported. The major compound 3β-friedelinol was found to contain 0.33 ± 0.03%, estimated through a validated HPTLC method. The extracts were non-toxic towards normal cell line H9C2 (cardiac myoblasts) and showed negligible cytotoxic effects towards cervical cancer cell line HeLa upto100 µg/mL concentration. The major compounds isolated from E. vajravelui were triterpenoids and single crystal XRD data unambiguously confirmed the structures. The latex extract was non toxic towards normal cell line H9C2 and cancer cell line HeLa and the result was relevant especially in the context of the eco-toxicological concerns around Euphorbia species. This is the first report of the phytochemical and cytotoxicity studies of the Western Ghats endemic species E. vajravelui.

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