Neuropsychological Effects of Deep Brain Stimulation in Subjects with Early Stage Parkinson's Disease in a Randomized Clinical Trial

2015 ◽  
Vol 5 (1) ◽  
pp. 151-163 ◽  
Author(s):  
Michael G. Tramontana ◽  
Anna L. Molinari ◽  
Peter E. Konrad ◽  
Thomas L. Davis ◽  
Scott A. Wylie ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Trial ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Randomized Clinical Trial ◽  
Brain Stimulation ◽  
Early Stage ◽  
Neuropsychological Effects ◽  
Deep Brain

Effects of deep brain stimulation on sleep-wake disturbances in patients with Parkinson's disease: A narrative review

2021 ◽  
Vol 19 ◽  
Author(s):  
Yu Jin Jung ◽  
Han-Joon Kim ◽  
Sun Ha Paek ◽  
Beomseok Jeon
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Early Stage ◽  
Motor Symptoms ◽  
Specific Effects ◽  
The Impact ◽  
Non Motor Symptoms ◽  
Deep Brain

: Sleep-wake disturbances (SWD) are one of the most common non-motor symptoms in Parkinson's disease (PD) and can appear in the early stage even before the onset of motor symptoms. Deep brain stimulation (DBS) is an established treatment for the motor symptoms in patients with advanced PD. However, the effect of DBS on SWD and its specific mechanisms are not widely understood and remain controversial. In addition to the circuit-mediated direct effect, DBS may improve SWD by an indirect effect such as the resolution of nocturnal motor complications and a reduction of dopaminergic medication. Here, the authors review the recent literatures regarding the impact of DBS on SWD in patients with PD. Furthermore, the selection of the DBS targets and the specific effects of applying DBS to each target on SWD in PD are also discussed.

scholarly journals Subthalamic nucleus deep brain stimulation in early stage Parkinson's disease

2014 ◽  
Vol 20 (7) ◽  
pp. 731-737 ◽  
Author(s):  
David Charles ◽  
Peter E. Konrad ◽  
Joseph S. Neimat ◽  
Anna L. Molinari ◽  
Michael G. Tramontana ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Early Stage ◽  
Deep Brain

scholarly journals Tackling psychosocial maladjustment in Parkinson’s disease patients following subthalamic deep-brain stimulation: A randomised clinical trial

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0174512 ◽  
Author(s):  
Joao Flores Alves Dos Santos ◽  
Sophie Tezenas du Montcel ◽  
Marcella Gargiulo ◽  
Cecile Behar ◽  
Sébastien Montel ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Trial ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Randomised Clinical Trial ◽  
Psychosocial Maladjustment ◽  
Deep Brain

Patient Perspectives on Deep Brain Stimulation Clinical Research in Early Stage Parkinson’s Disease

2017 ◽  
Vol 7 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Lauren Heusinkveld ◽  
Mallory Hacker ◽  
Maxim Turchan ◽  
Madelyn Bollig ◽  
Christina Tamargo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Clinical Research ◽  
Brain Stimulation ◽  
Early Stage ◽  
Patient Perspectives ◽  
Deep Brain

scholarly journals A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying Effects

2021 ◽  
Vol 05 (02) ◽  
pp. 1-1
Author(s):  
Francesco Sciancalepore ◽  
◽  
Giulia Remoli ◽  
Leonardo Tariciotti ◽  
Giulia Sarti ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Early Stage ◽  
Case Reports ◽  
Biological Processes ◽  
Inclusion Criteria ◽  
Disease Modifying ◽  
Deep Brain

Deep-Brain Stimulation (DBS) is an important treatment option for the management of Parkinson’s disease (PD) and is a common symptomatic treatment. However, an increasing number of studies have examined the biological processes to assess if DBS can also modify the natural history of PD by acting on its pathophysiological mechanisms. Relevant literature published up to November 2020 was systematically searched on databases such as PubMed, ISI Web of Knowledge, Academic Search Index, and Science Citation Index. The following predefined inclusion criteria were applied to the full-text versions of the selected articles: i) recruiting and monitoring of PD subjects that were previously treated with DBS and ii) investigating the electrophysiological, biochemical, epigenetic, or neuroimaging effects of DBS. Studies focusing exclusively on motor and clinical changes were excluded. Reviews, case reports, studies on animal models, and computational studies were also not considered. Out of 2,960 records screened, 43 studies met the inclusion criteria. Only three studies described a potential disease-modifying effect of DBS. However, a wide heterogeneity was observed in the investigated biomarkers, and the design and methodological issues of several studies limited their ability to find potential disease-modifying features. Specifically, 60.4% of the trials followed-up subjects for no more than 1 year from the surgical intervention, and 67.4% observed patients with PD only once after DBS. Moreover, 64.2% of the studies enrolled late-stage PD patients. Most of the studies (88.4%) reported that DBS only had a symptomatic effect, with several of them showing some limitations in the study design and recruitment of patients. Further studies using shared biomarkers are encouraged to assess if and how DBS might affect the progression of PD. Based on the existing preclinical literature, prospective clinical trials examining the course of PD in early-stage patients are needed.

scholarly journals Deep Brain Stimulation for Early-Stage Parkinson's Disease: An Illustrative Case

2011 ◽  
Vol 14 (6) ◽  
pp. 515-522 ◽  
Author(s):  
Chandler E. Gill ◽  
Laura A. Allen ◽  
Peter E. Konrad ◽  
Thomas L. Davis ◽  
Mark J. Bliton ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Early Stage ◽  
Illustrative Case ◽  
Deep Brain
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