scholarly journals Young adulthood cardiovascular risk and MRI and amyloid PET in late‐life in a diverse cohort: The Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Kristen M. George ◽  
Rachel A. Whitmer ◽  
Elizabeth Rose Mayeda ◽  
M. Maria Glymour ◽  
Dan M Mungas ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Young Adulthood ◽  
Healthy Aging ◽  
Life Experiences ◽  
Late Life ◽  
Amyloid Pet

scholarly journals Impact of Cardiovascular Risk Factors in Adolescence, Young Adulthood, and Midlife on Late-life Cognition: Study of Healthy Aging in African Americans (STAR)

2021 ◽  
Author(s):  
Kristen M George ◽  
Paola Gilsanz ◽  
Rachel L Peterson ◽  
Lisa L Barnes ◽  
Charles S DeCarli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Executive Function ◽  
Cardiovascular Risk ◽  
African Americans ◽  
Episodic Memory ◽  
Young Adulthood ◽  
Healthy Aging ◽  
Black Americans ◽  
Late Life ◽  
Verbal Episodic Memory

Abstract Background Midlife cardiovascular risk factors (CVRF) increase risk of dementia. Black Americans experience an elevated prevalence of CVRF and dementia. However, little is known of how CVRF prior to midlife affect late-life cognition. We examined CVRF in adolescence, young adulthood, and midlife with late-life cognition in The Study of Healthy Aging in African Americans (STAR). Methods STAR assesses cognitive aging among 764 Black Americans ages ≥50 (mean age=69;SD=9;range 53-95). Participants’ body mass index, blood pressure, glucose, and total cholesterol were collected during Multiphasic Health Check-ups (MHC;1964-1985). At STAR baseline (2018-2019), executive function, verbal episodic memory, and semantic memory were measured using the Spanish and English Neuropsychological Assessment Scales. Linear regression models examined associations between CVRF and cognition adjusting for demographics and years since MHC. Results At MHC, 36% of participants had 1 CVRF and 26% had ≥2. Twenty-two percent of participants were adolescents (ages:12-20), 62% young adults (ages:21-34), and 16% midlife adults (ages:35-56). Overweight/obesity was not associated with cognition. Hypertension was associated with worse executive function [β(95%CI):-0.14(-0.28,-0.0003)] and verbal episodic memory [β(95%CI):-0.22(-0.37,-0.07)] compared to normotension. Diabetes was associated with worse executive function [β(95%CI):-0.43(-0.83,-0.03)]. Having ≥2 CVRF (versus 0) was associated with worse executive function [β(95%CI):-0.19(-0.34,-0.03)] and verbal episodic memory [β(95%CI):-0.25(-0.41,-0.08)]. Adolescents with hypertension had lower late-life executive function compared to normotensive adolescents [β(95%CI):-0.39(-0.67,-0.11)]. Young adulthood hypertension [β(95%CI):-0.29(-0.49,-0.09)] and midlife hyperlipidemia [β(95%CI):-0.386(-0.70,-0.02)] were associated with lower verbal episodic memory. Conclusions Among Black Americans, lifecourse CVRF were associated with poorer executive function and verbal episodic memory emphasizing the importance of cardiovascular health on the aging brain.

scholarly journals Racial/Ethnic Disparities in Young Adulthood and Midlife Cardiovascular Risk Factors and Late-life Cognitive Domains

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Rachel L. Peterson ◽  
Kristen M. George ◽  
Paola Gilsanz ◽  
Sarah Ackley ◽  
Elizabeth R. Mayeda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Young Adulthood ◽  
Ethnic Disparities ◽  
Late Life ◽  
Cognitive Domains ◽  
Racial Ethnic

scholarly journals Cardiovascular risk factors in adolescence and adulthood and late‐life cognition: Study of Healthy Aging in African Americans (STAR)

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Kristen M George ◽  
Rachel Peterson ◽  
Paola Gilsanz ◽  
Lisa L Barnes ◽  
M Maria Glymour ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
African Americans ◽  
Cardiovascular Risk Factors ◽  
Healthy Aging ◽  
Late Life

scholarly journals Relationship between MRI and amyloid PET measures with cognition in the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Kristen M. George ◽  
Rachel A Whitmer ◽  
M Maria Glymour ◽  
Elizabeth Rose Mayeda ◽  
Dan M Mungas ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Life Experiences ◽  
Amyloid Pet

scholarly journals Are adverse childhood experiences associated with late-life cognitive performance across racial/ethnic groups: results from the Kaiser Healthy Aging and Diverse Life Experiences study baseline

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e042125
Author(s):  
Audra L Gold ◽  
Erika Meza ◽  
Sarah F Ackley ◽  
Dan M Mungas ◽  
Rachel A Whitmer ◽  
...  
Keyword(s):  
Ethnic Groups ◽  
Adverse Childhood Experiences ◽  
Healthy Aging ◽  
Life Experiences ◽  
Late Life ◽  
Cognitive Outcomes ◽  
Northern California ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Racial Ethnic

ObjectivesEvidence on adverse childhood experiences (ACEs) and late-life cognitive outcomes is inconsistent, with little research among diverse racial/ethnic groups. We investigated whether ACE exposures were associated with worse late-life cognition for all racial/ethnic groups and at different ages of exposure.DesignCovariate-adjusted mixed-effects linear regression models estimated associations of: (1) total number of ACEs experienced, (2) earliest age when ACE occurred and (3) type of ACE with overall cognition.SettingKaiser Permanente Northern California members aged 65 years and older, living in Northern California.ParticipantsKaiser Healthy Aging and Diverse Life Experiences study baseline participants, aged 65 years and older (n=1661; including 403 Asian-American, 338 Latino, 427 Black and 493 white participants).ResultsMost respondents (69%) reported one or more ACE, most frequently family illness (36%), domestic violence (23%) and parental divorce (22%). ACE count was not adversely associated with cognition overall (β=0.01; 95% CI −0.01 to 0.03), in any racial/ethnic group or for any age category of exposure. Pooling across all race/ethnicities, parent’s remarriage (β=−0.11; 95% CI −0.20 to −0.03), mother’s death (β=−0.18; 95% CI −0.30 to −0.07) and father’s death (β=−0.11; 95% CI −0.20 to −0.01) were associated with worse cognition.ConclusionAdverse childhood exposures overall were not associated with worse cognition in older adults in a diverse sample, although three ACEs were associated with worse cognitive outcomes.

Cognitive performance in young adulthood and midlife: Relations with age, sex, and education—The Cardiovascular Risk in Young Finns Study.

2016 ◽  
Vol 30 (5) ◽  
pp. 532-542 ◽  
Author(s):  
Suvi P. Rovio ◽  
Katja Pahkala ◽  
Jaakko Nevalainen ◽  
Markus Juonala ◽  
Pia Salo ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Cognitive Performance ◽  
Young Adulthood ◽  
Young Finns Study

Trauma Caused by Injury or Abuse in Late Life: Experiences, Impacts, and the Federal Response

2019 ◽  
Author(s):  
Vijeth Iyengar ◽  
Greg Link ◽  
Phillip W. Beatty ◽  
Madeleine Boel ◽  
Cailin Crockett ◽  
...  
Keyword(s):  
Life Experiences ◽  
Late Life ◽  
Federal Response

scholarly journals Contribution of IQ in young adulthood to the associations of education and occupation with cognitive ability in older age

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Insa Feinkohl ◽  
Petra Kozma ◽  
Friedrich Borchers ◽  
Simone J. T. van Montfort ◽  
Jochen Kruppa ◽  
...  
Keyword(s):  
Higher Education ◽  
Cognitive Ability ◽  
Young Adulthood ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Late Life ◽  
Summary Score ◽  
Unique Contribution ◽  
Cross Sectional ◽  
Sectional Analysis

Abstract Background Studies suggest that a higher education and occupation are each associated with a higher late-life cognitive ability, but their inter-relationships in their association with cognitive ability and the contribution of peak IQ in young adulthood (‘pre-morbid IQ’) often remain unclear. Methods Cross-sectional analysis of 623 participants aged ≥65 years of the BioCog study. Education was coded according to the International Standard Classification of Education (ISCED; range 1 to 6). Occupation was coded as ‘semi/unskilled’, ‘skilled manual’, ‘skilled non-manual’, ‘managerial’, ‘professional’. A summary score of global ability (‘g’) was constructed from six cognitive tests. Pre-morbid IQ was estimated from vocabulary. The Geriatric Depression Scale assessed symptoms of depression. Age- and sex-adjusted analyses of covariance were performed. Results Education (partial eta2 0.076; p < 0.001) and occupation (partial eta2 = 0.037; p < 0.001) were each significantly associated with g. For education, the association was attenuated but remained statistically significant when pre-morbid IQ was controlled for (partial eta2 0.036; p < 0.001) and was unchanged with additional adjustment for depression (partial eta2 0.037; p < 0.001). For occupation, the association with g was no longer significant when pre-morbid IQ (partial eta2 = 0.015; p = 0.06) and depression (partial eta2 = 0.011; p = 0.18) were entered as covariates in separate steps. When education and occupation were entered concurrently into the fully adjusted model, only education was independently associated with g (partial eta2 0.030; p < 0.001; occupation, p = 0.93). Conclusion While a higher education and a higher occupation were each associated with a higher late-life cognitive ability, only for education some unique contribution to cognitive ability remained over and above its relationship with pre-morbid IQ, depression, and occupation. Further research is needed to address whether a longer time spent in education may promote late-life cognitive ability.

scholarly journals Early adulthood and midlife cardiovascular risk factors and late‐life cognition in KHANDLE: A lifecourse study of a diverse cohort

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Rachel Peterson ◽  
Kristen M. George ◽  
Paola Gilsanz ◽  
Elizabeth Rose Mayeda ◽  
M. Maria Glymour ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Early Adulthood ◽  
Late Life
Sign in / Sign up

Export Citation Format

Share Document