scholarly journals Cardiovascular risk factors in adolescence and adulthood and late‐life cognition: Study of Healthy Aging in African Americans (STAR)

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Kristen M George ◽  
Rachel Peterson ◽  
Paola Gilsanz ◽  
Lisa L Barnes ◽  
M Maria Glymour ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
African Americans ◽  
Cardiovascular Risk Factors ◽  
Healthy Aging ◽  
Late Life

scholarly journals Impact of Cardiovascular Risk Factors in Adolescence, Young Adulthood, and Midlife on Late-life Cognition: Study of Healthy Aging in African Americans (STAR)

2021 ◽  
Author(s):  
Kristen M George ◽  
Paola Gilsanz ◽  
Rachel L Peterson ◽  
Lisa L Barnes ◽  
Charles S DeCarli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Executive Function ◽  
Cardiovascular Risk ◽  
African Americans ◽  
Episodic Memory ◽  
Young Adulthood ◽  
Healthy Aging ◽  
Black Americans ◽  
Late Life ◽  
Verbal Episodic Memory

Abstract Background Midlife cardiovascular risk factors (CVRF) increase risk of dementia. Black Americans experience an elevated prevalence of CVRF and dementia. However, little is known of how CVRF prior to midlife affect late-life cognition. We examined CVRF in adolescence, young adulthood, and midlife with late-life cognition in The Study of Healthy Aging in African Americans (STAR). Methods STAR assesses cognitive aging among 764 Black Americans ages ≥50 (mean age=69;SD=9;range 53-95). Participants’ body mass index, blood pressure, glucose, and total cholesterol were collected during Multiphasic Health Check-ups (MHC;1964-1985). At STAR baseline (2018-2019), executive function, verbal episodic memory, and semantic memory were measured using the Spanish and English Neuropsychological Assessment Scales. Linear regression models examined associations between CVRF and cognition adjusting for demographics and years since MHC. Results At MHC, 36% of participants had 1 CVRF and 26% had ≥2. Twenty-two percent of participants were adolescents (ages:12-20), 62% young adults (ages:21-34), and 16% midlife adults (ages:35-56). Overweight/obesity was not associated with cognition. Hypertension was associated with worse executive function [β(95%CI):-0.14(-0.28,-0.0003)] and verbal episodic memory [β(95%CI):-0.22(-0.37,-0.07)] compared to normotension. Diabetes was associated with worse executive function [β(95%CI):-0.43(-0.83,-0.03)]. Having ≥2 CVRF (versus 0) was associated with worse executive function [β(95%CI):-0.19(-0.34,-0.03)] and verbal episodic memory [β(95%CI):-0.25(-0.41,-0.08)]. Adolescents with hypertension had lower late-life executive function compared to normotensive adolescents [β(95%CI):-0.39(-0.67,-0.11)]. Young adulthood hypertension [β(95%CI):-0.29(-0.49,-0.09)] and midlife hyperlipidemia [β(95%CI):-0.386(-0.70,-0.02)] were associated with lower verbal episodic memory. Conclusions Among Black Americans, lifecourse CVRF were associated with poorer executive function and verbal episodic memory emphasizing the importance of cardiovascular health on the aging brain.

scholarly journals Early adulthood and midlife cardiovascular risk factors and late‐life cognition in KHANDLE: A lifecourse study of a diverse cohort

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Rachel Peterson ◽  
Kristen M. George ◽  
Paola Gilsanz ◽  
Elizabeth Rose Mayeda ◽  
M. Maria Glymour ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Early Adulthood ◽  
Late Life

scholarly journals Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging

2019 ◽  
Vol 74 ◽  
pp. 46-55 ◽  
Author(s):  
Delia Fuhrmann ◽  
David Nesbitt ◽  
Meredith Shafto ◽  
James B. Rowe ◽  
Darren Price ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
White Matter ◽  
Cardiovascular Risk Factors ◽  
Healthy Aging

Midlife cardiovascular risk factors and risk of dementia in late life

Neurology ◽  
2005 ◽  
Vol 64 (2) ◽  
pp. 277-281 ◽  
Author(s):  
R. A. Whitmer ◽  
S. Sidney ◽  
J. Selby ◽  
S. C. Johnston ◽  
K. Yaffe
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Late Life

scholarly journals Healthy aging of the left ventricle in relationship to cardiovascular risk factors: The Multi-Ethnic Study of Atherosclerosis (MESA)

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179947 ◽  
Author(s):  
Chia-Ying Liu ◽  
Shenghan Lai ◽  
Nadine Kawel-Boehm ◽  
Harjit Chahal ◽  
Bharath Ambale-Venkatesh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Left Ventricle ◽  
Cardiovascular Risk Factors ◽  
Healthy Aging ◽  
Ethnic Study

scholarly journals Association among sickle cell trait, fitness, and cardiovascular risk factors in CARDIA

Blood ◽  
2017 ◽  
Vol 129 (6) ◽  
pp. 723-728 ◽  
Author(s):  
Robert I. Liem ◽  
Cheeling Chan ◽  
Thanh-Huyen T. Vu ◽  
Myriam Fornage ◽  
Alexis A. Thompson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
African Americans ◽  
Cardiovascular Risk Factors ◽  
Sickle Cell ◽  
Independent Risk Factor ◽  
Sickle Cell Trait ◽  
Key Points

Key Points SCT status is not significantly associated with longitudinal changes in fitness among African Americans. SCT status is not an independent risk factor for hypertension, diabetes, or metabolic syndrome among African Americans.

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