scholarly journals Early adulthood and midlife cardiovascular risk factors and late‐life cognition in KHANDLE: A lifecourse study of a diverse cohort

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Rachel Peterson ◽  
Kristen M. George ◽  
Paola Gilsanz ◽  
Elizabeth Rose Mayeda ◽  
M. Maria Glymour ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Early Adulthood ◽  
Late Life

Cardiovascular Risk Factors Across the Life Course and Cognitive Decline

Neurology ◽  
2021 ◽  
Vol 96 (17) ◽  
pp. e2212-e2219
Author(s):  
Kristine Yaffe ◽  
Eric Vittinghoff ◽  
Tina Hoang ◽  
Karen Matthews ◽  
Sherita H. Golden ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Life Course ◽  
Cognitive Decline ◽  
Cardiovascular Risk Factors ◽  
Early Adulthood ◽  
Late Life ◽  
Digit Symbol Substitution Test ◽  
Increased Risk ◽  
The Life Course

ObjectiveCardiovascular risk factors (CVRFs) are associated with increased risk of cognitive decline, but little is known about how early adult CVRFs and those across the life course might influence late-life cognition. To test the hypothesis that CVRFs across the adult life course are associated with late-life cognitive changes, we pooled data from 4 prospective cohorts (n = 15,001, ages 18–95).MethodsWe imputed trajectories of body mass index (BMI), fasting glucose (FG), systolic blood pressure (SBP), and total cholesterol (TC) for older adults. We used linear mixed models to determine the association of early adult, midlife, and late-life CVRFs with late-life decline on global cognition (Modified Mini-Mental State Examination [3MS]) and processing speed (Digit Symbol Substitution Test [DSST]), adjusting for demographics, education, and cohort.ResultsElevated BMI, FG, and SBP (but not TC) at each time period were associated with greater late-life decline. Early life CVRFs were associated with the greatest change, an approximate doubling of mean 10-year decline (an additional 3–4 points for 3MS or DSST). Late-life CVRFs were associated with declines in early late life (<80 years) but with gains in very late life (≥80 years). After adjusting for CVRF exposures at all time periods, the associations for early adult and late-life CVRFs persisted.ConclusionsWe found that imputed CVRFs across the life course, especially in early adulthood, were associated with greater late-life cognitive decline. Our results suggest that CVRF treatment in early adulthood could benefit late-life cognition, but that treatment in very late life may not be as helpful for these outcomes.

Midlife cardiovascular risk factors and risk of dementia in late life

Neurology ◽  
2005 ◽  
Vol 64 (2) ◽  
pp. 277-281 ◽  
Author(s):  
R. A. Whitmer ◽  
S. Sidney ◽  
J. Selby ◽  
S. C. Johnston ◽  
K. Yaffe
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Late Life

O1-05-02: Cardiovascular risk factors for cognitive function: Effects from early adulthood to mid-life

2013 ◽  
Vol 9 ◽  
pp. P135-P135
Author(s):  
Kristine Yaffe ◽  
Eric Vittinghoff ◽  
Mark Pletcher ◽  
Tina Hoang ◽  
Lenore Launer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cognitive Function ◽  
Cardiovascular Risk Factors ◽  
Early Adulthood

scholarly journals Racial/Ethnic Disparities in Young Adulthood and Midlife Cardiovascular Risk Factors and Late-life Cognitive Domains

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Rachel L. Peterson ◽  
Kristen M. George ◽  
Paola Gilsanz ◽  
Sarah Ackley ◽  
Elizabeth R. Mayeda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Young Adulthood ◽  
Ethnic Disparities ◽  
Late Life ◽  
Cognitive Domains ◽  
Racial Ethnic

scholarly journals Cardiovascular risk factors in adolescence and adulthood and late‐life cognition: Study of Healthy Aging in African Americans (STAR)

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Kristen M George ◽  
Rachel Peterson ◽  
Paola Gilsanz ◽  
Lisa L Barnes ◽  
M Maria Glymour ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
African Americans ◽  
Cardiovascular Risk Factors ◽  
Healthy Aging ◽  
Late Life

scholarly journals No Association between Low Birth Weight and Cardiovascular Risk Factors in Early Adulthood: Evidence from São Paulo, Brazil

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66554 ◽  
Author(s):  
Filumena Maria Gomes ◽  
S. V. Subramanian ◽  
Ana Maria de Ulhôa Escobar ◽  
Maria Helena Valente ◽  
Sandra Josefina Ferraz Ellero Grisi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Cardiovascular Risk Factors ◽  
Early Adulthood ◽  
Sao Paulo ◽  
São Paulo
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