Synthetic Approaches to the Anticancer Agent Fredericamycin A

2020 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Ambareen Fatma
Keyword(s):  
Anticancer Agent ◽  
Fredericamycin A ◽  
Synthetic Approaches

A Review on Synthetic Approaches of Phenanthridine

2021 ◽  
Vol 18 ◽  
Author(s):  
Nilesh Kshirsagar ◽  
Ratnamala Sonawane ◽  
Sultan Pathan ◽  
Ganesh Kamble ◽  
Girdhar Pal Singh
Keyword(s):  
Biological Activity ◽  
Transition Metal ◽  
Material Science ◽  
Anticancer Agent ◽  
Hypervalent Iodine ◽  
One Pot ◽  
Bond Forming ◽  
Microwave Assisted ◽  
Metal Catalyzed ◽  
Synthetic Approaches

Abstract: The phenanthridine family is widely found in medicinal chemistry and material science because of the biological activity and the presence in a variety of significant natural products and synthetic dye-stuffs. The phenanthridine has many clinical application like anticancer agent, antibacterial, antiprotozoal, pharmaceutically, and optoelectronic properties. Many methods have been reported for the synthesis of phenanthridine and phenanthridine alkaloids such as Pd catalyzed C-C bond forming. Reaction involving C-H activation , Radical, Microwave-assisted , transition metal catalyzed, one- pot cascade, benzyne mediated, photochemical, hypervalent iodine promoted ,etc. Here we summarized the literature data from 2014 to present concerning a novel or improved synthetic approaches.

Fused and Substituted Pyrimidine Derivatives as a Profound Anticancer Agent

2020 ◽  
Vol 20 ◽  
Author(s):  
Nahid Abbas ◽  
Gurubasavaraja S.P. Matada ◽  
Prasad S. Dhiwar ◽  
Shilpa Patel ◽  
Giles Devasahayam
Keyword(s):  
Small Molecules ◽  
Anticancer Agent ◽  
Targeted Agents ◽  
Pyrimidine Derivatives ◽  
Biological Targets ◽  
Routes Of Administration ◽  
Heterocyclic Molecules ◽  
Structural Activity Relationship ◽  
Synthetic Approaches ◽  
Relationship Of

: The rationale behind drug design is strategic utilization of heterocyclic fragments with specific physicochemical properties to form molecular targeted agents. Among the heterocyclic molecules, pyrimidine has proved to be a privileged pharmacophore for various biological cancer targets. The anticancer potential of small molecules with fused and substituted pyrimidine can be enhanced through bioisosteric replacements and altering their ADME parameters. Despite of several small molecules used in cancer chemotherapy, oncology therapeutics has various limitations. Especially in their routes of administration and their concurrent side effects. Such pernicious effects may be overcome, via selective biological targeting. In this review we have discussed the biological targets to inhibit cancer. Structural activity relationship of fused and substituted pyrimidine was studied. Eco friendly synthetic approaches for pyrimidine derivatives have been discussed. This review will give an insight to scientists and researchers of medicinal chemistry discipline to design small molecules having a pyrimidine scaffold with high anticancer potential.

Benzimidazole Scaffold as Anticancer Agent: Synthetic Approaches and Structure-Activity Relationship

2017 ◽  
Vol 350 (6) ◽  
pp. e201700040 ◽  
Author(s):  
Neelima Shrivastava ◽  
Mohd. Javed Naim ◽  
Md. Jahangir Alam ◽  
Farah Nawaz ◽  
Shujauddin Ahmed ◽  
...  
Keyword(s):  
Anticancer Agent ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Synthetic Approaches

Pyridyl disulfide-based thiol–disulfide exchange reaction: shaping the design of redox-responsive polymeric materials

2020 ◽  
Vol 11 (48) ◽  
pp. 7603-7624
Author(s):  
Ismail Altinbasak ◽  
Mehmet Arslan ◽  
Rana Sanyal ◽  
Amitav Sanyal
Keyword(s):  
Exchange Reaction ◽  
Functional Materials ◽  
Polymeric Materials ◽  
Disulfide Exchange ◽  
Redox Responsive ◽  
Synthetic Approaches

This review provides an overview of synthetic approaches utilized to incorporate the thiol-reactive pyridyl-disulfide motif into various polymeric materials, and briefly highlights its utilization to obtain functional materials.

The Therapeutic and Diagnostic Value of Fluorine

2020 ◽  
Vol 4 (1) ◽  
pp. 17-29
Author(s):  
Isma Attique ◽  
Shabbir Hussain ◽  
Muhammad Amjad ◽  
Khalida Nazir ◽  
Muhammad Shahid Nazir
Keyword(s):  
Anticancer Agent ◽  
Chemotherapeutic Agent ◽  
Functional Materials ◽  
Diagnostic Value ◽  
Vital Role ◽  
Malignant Growth ◽  
Medical Field ◽  
Active Nucleus ◽  
Broad Application ◽  
Tracer Atom

Fluorine has a useful positron transmitting isotope and it enjoys broad application in the medical field. It is utilized in fluorinated agents,therapeutic sciences and steroid field. Fluorine incorporation viafluoroalkylation is a useful approach in the development of new functional materials and in drug design. Fluorine also plays its role as an anticancer agent and is a successful chemotherapeutic agent for certain sorts of malignant growth. 5-fluorouracil plays a vital role in the treatment of cancer. 18 Facts as a radio label tracer atom in PET imaging. 19 F has the second most sensitive and stable NMR-active nucleus.

Non-Steroidal Anti-inflammatory Drugs (NSAIDs): Synthesis of Ibuprofen, Naproxen and Nabumetone

2019 ◽  
pp. 19-27
Keyword(s):  
Review Paper ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Synthetic Approaches

This review paper covers the major synthetic approaches attempted towards the synthesis of some Non-Steroidal Anti-Inflammatory Drugs (Naproxen, Ibuprofen and Nabumetone)

Aryl-substituted Triarsiranes: Synthesis and Reactivity

2020 ◽  
Author(s):  
André Schumann ◽  
Jonas Bresien ◽  
Malte Fischer ◽  
Christian Hering-Junghans
Keyword(s):  
Organic Chemistry ◽  
Electronic Structure ◽  
Heterocyclic Carbenes ◽  
Synthetic Approaches ◽  
Inorganic And Organic

Cyclotriarsanes are rare and limited synthetic approaches have hampered reactivity studies on these systems. Described in here is a scalable synthetic protocol towards (AsAr)<sub>3</sub> (Ar = Dip, 2,6-<sup>i</sup>Pr<sub>2</sub>-C<sub>6</sub>H<sub>3</sub>; Tip, 2,4,6-<sup>i</sup>Pr<sub>3</sub>-C<sub>6</sub>H<sub>2</sub>), which allowed to study their reactivity towards [Cp<sub>2</sub>Ti(C<sub>2</sub>(SiMe<sub>3</sub>)<sub>2</sub>], affording titanocene diarsene complexes and towards N-heterocyclic carbenes (NHCs) to give straightforward access to a variety of NHC-arsinidene adducts. The electronic structure of the titanium diarsene complxes has been studied and they are best described as Ti(IV) species with a doubly reduced As<sub>2</sub>Ar<sub>2</sub> ligand. These findings will make (AsAr)<sub>3</sub> valuable precursors in the synthetic inorganic and organic chemistry.

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