Benzimidazole Scaffold as Anticancer Agent: Synthetic Approaches and Structure-Activity Relationship

2017 ◽  
Vol 350 (6) ◽  
pp. e201700040 ◽  
Author(s):  
Neelima Shrivastava ◽  
Mohd. Javed Naim ◽  
Md. Jahangir Alam ◽  
Farah Nawaz ◽  
Shujauddin Ahmed ◽  
...  
Keyword(s):  
Anticancer Agent ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Synthetic Approaches

The Chemical Syntheses of Nannocystins

Synthesis ◽  
2019 ◽  
Vol 51 (11) ◽  
pp. 2252-2260
Author(s):  
Zhang Wang
Keyword(s):  
Natural Products ◽  
Anticancer Activity ◽  
Short Review ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Total Syntheses ◽  
Sar Studies ◽  
Structure Activity ◽  
Synthetic Approaches

The broad and potent anticancer activity of the nannocystin family of natural products has attracted significant efforts toward their total syntheses. Currently, seven total syntheses of different members of the nannocystins have been reported. In this Short Review, different synthetic approaches are highlighted. The reported structure-activity relationship (SAR) studies will also be highlighted.

Searching for Potential HDAC2 Inhibitors: Structure-activity Relationship Studies on Indole-based Hydroxamic Acids as an Anticancer Agent

2020 ◽  
Vol 17 (7) ◽  
pp. 905-917
Author(s):  
Ekta Shirbhate ◽  
Divya ◽  
Preeti Patel ◽  
Vijay K. Patel ◽  
Ravichandran Veerasamy ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Histone Deacetylase ◽  
Anticancer Agent ◽  
3D Qsar ◽  
Integrated Approach ◽  
Structure Activity Relationship ◽  
Molecular Target ◽  
Activity Relationship ◽  
Structure Activity ◽  
Current Scenario

Aim: To predict the most potent indole based HDAC2 inhibitors from several scientific reports through the process of lead identification and SAR development. Background: The current scenario is observing Histone Deacetylase (HDAC) as an alluring molecular target for the designing and development of drugs for cancer treatment. Background: The current scenario is observing Histone Deacetylase (HDAC) as an alluring molecular target for the designing and development of drugs for cancer treatment. Objective: To identify the lead and establish structure-activity correlation among indole based hydroxamic acid to find out promising HDAC2 based anticancer agent. Methods: A dataset containing 59 molecules was analyzed using structure and ligand-based integrated approach comprising atom-based 3D-QSAR (Quantitative Structure-Activity Relationship) and pharmacophore study, e-pharmacophore mapping and molecular modeling methodologies. The finest model was prepared by amalgamating the properties of electronegativity, polarizability, Vander Waals forces and other conformational aspects. Results: The result of 3D QSAR analysis, performed for 4 PLS factor, provided the following statistical information: R2 = 0.9461, Q2 = 0.7342 and low standard of deviation SD = 0.1744 for hypothesis ADDDH.10 and R2 = 0.9444, Q2= 0.7858 and again low standard of deviation SD = 0.1795 for hypothesis DDHRR.12. The XP molecular docking showed intermolecular interactions of small molecules with amino acids such as GLY154, HIP145, PHE210, HIE183, internal H2O and Zn2+. Conclusion: The interpretation of data generated as a result of this investigation clearly hints about the better biological activity of test compounds as compared to SAHA. Hence, the outcome of these structure and ligand-based integrated studies could be employed for the design of novel arylindole derivatives as a potent HDAC inhibitor.

Structure-activity relationship studies of isoquinolinone type anticancer agent

2001 ◽  
Vol 24 (4) ◽  
pp. 276-280 ◽  
Author(s):  
Seung Hoon Cheon ◽  
Joon Suck Park ◽  
Joon Yeol Lee ◽  
You Na Lee ◽  
Hyo Yi ◽  
...  
Keyword(s):  
Anticancer Agent ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
Sign in / Sign up

Export Citation Format

Share Document