Iron oxide‐loaded polymer scaffolds for non‐invasive hyperthermic treatment of infiltrated cells

AIChE Journal ◽  
2020 ◽  
Vol 66 (12) ◽  
Author(s):  
Tiffany Lam ◽  
Alyssa Moy ◽  
Hak Rae Lee ◽  
Qi Shao ◽  
John C. Bischof ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Polymer Scaffolds ◽  
Non Invasive ◽  
Hyperthermic Treatment

Characterization of Cell Association and Heat Treatment Using Iron Oxide Magnetic Nanoparticles

2007 ◽  
Author(s):  
Venkat S. Kalambur ◽  
Ellen Longmire ◽  
John C. Bischof
Keyword(s):  
Iron Oxide ◽  
Cell Sorting ◽  
Biomedical Applications ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Non Invasive ◽  
Cell Association ◽  
Iron Oxide Magnetic Nanoparticles ◽  
Magnetic Resonance Imaging Mri

Magnetic iron oxide nanoparticles (NPs) have intrinsic advantages over other NPs for various biomedical applications. These advantages include visualization under Magnetic Resonance Imaging (MRI), heating with Radiofrequency (RF), and movement in a magnetic field. There are now numerous efforts to expand the applications of these particles for non-invasive drug and adjuvant delivery, cellular imaging and in vitro cell sorting and purification. In the present study, we describe methods to (i) assess and quantify NP cell association (ii) facilitate NP heat destruction of cells after association with RF and laser. First, we show that (i) the cell association of iron oxide NPs is dependent on the surface coating (surfactant greater than dextran), time, cell-type and extracellular NP concentrations (saturation with concentration and time). Furthermore, the association fits a simple enzyme Michealis-Menten model. Second, (ii) improved heat destruction of cells can be achieved after laser irradiation compared to traditional RF treatment for similar NP associations. These results and assays show promise for cell sorting and purification applications.

Non-invasive Imaging of Tissue-Engineered Vascular Endothelium with Iron Oxide Nanoparticles

nano Online ◽  
2016 ◽  
Author(s):  
J. Frese ◽  
L. Hrdlicka ◽  
M. E. Mertens ◽  
L. Rongen ◽  
S. Koch ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Vascular Endothelium ◽  
Oxide Nanoparticles ◽  
Non Invasive

Non-invasive Imaging of Tissue-Engineered Vascular Endothelium with Iron Oxide Nanoparticles

2012 ◽  
Vol 57 (SI-1 Track-G) ◽  
Author(s):  
J. Frese ◽  
L. Hrdlicka ◽  
M. E. Mertens ◽  
L. Rongen ◽  
S. Koch ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Vascular Endothelium ◽  
Oxide Nanoparticles ◽  
Non Invasive

scholarly journals Collagen Scaffolds: Iron Oxide-Labeled Collagen Scaffolds for Non-Invasive MR Imaging in Tissue Engineering (Adv. Funct. Mater. 6/2014)

2014 ◽  
Vol 24 (6) ◽  
pp. 722-722
Author(s):  
Marianne E. Mertens ◽  
Alina Hermann ◽  
Anne Bühren ◽  
Leon Olde-Damink ◽  
Diana Möckel ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Iron Oxide ◽  
Mr Imaging ◽  
Collagen Scaffolds ◽  
Non Invasive

scholarly journals A Novel Approach for Non-Invasive Lung Imaging and Targeting Lung Immune Cells

2020 ◽  
Vol 21 (5) ◽  
pp. 1613 ◽  
Author(s):  
Amlan Chakraborty ◽  
Simon Royce ◽  
Cordelia Selomulya ◽  
Magdalena Plebanski
Keyword(s):  
Iron Oxide ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Immune Cells ◽  
Alveolar Macrophages ◽  
Lung Imaging ◽  
Oxide Nanoparticles ◽  
Super Paramagnetic Iron Oxide ◽  
Non Invasive ◽  
The Impact

Despite developments in pulmonary radiotherapy, radiation-induced lung toxicity remains a problem. More sensitive lung imaging able to increase the accuracy of diagnosis and radiotherapy may help reduce this problem. Super-paramagnetic iron oxide nanoparticles are used in imaging, but without further modification can cause unwanted toxicity and inflammation. Complex carbohydrate and polymer-based coatings have been used, but simpler compounds may provide additional benefits. Herein, we designed and generated super-paramagnetic iron oxide nanoparticles coated with the neutral natural dietary amino acid glycine (GSPIONs), to support non-invasive lung imaging and determined particle biodistribution, as well as understanding the impact of the interaction of these nanoparticles with lung immune cells. These GSPIONs were characterized to be crystalline, colloidally stable, with a size of 12 ± 5 nm and a hydrodynamic diameter of 84.19 ± 18 nm. Carbon, Hydrogen, Nitrogen (CHN) elemental analysis estimated approximately 20.2 × 103 glycine molecules present per nanoparticle. We demonstrated that it is possible to determine the biodistribution of the GSPIONs in the lung using three-dimensional (3D) ultra-short echo time magnetic resonance imaging. The GSPIONs were found to be taken up selectively by alveolar macrophages and neutrophils in the lung. In addition, the GSPIONs did not cause changes to airway resistance or induce inflammatory cytokines. Alveolar macrophages and neutrophils are critical regulators of pulmonary inflammatory diseases, including allergies, infections, asthma and chronic obstructive pulmonary disease (COPD). Therefore, pulmonary Magnetic Resonance (MR) imaging and preferential targeting of these lung resident cells by our nanoparticles offer precise imaging tools, which can be utilized to develop precision targeted radiotherapy as well as diagnostic tools for lung cancer, thereby having the potential to reduce the pulmonary complications of radiation.

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