scholarly journals Cyclic Arginine–Glycine–Aspartate‐Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes

2021 ◽  
pp. 2100370
Author(s):  
Alexandros Marios Sofias ◽  
Geir Bjørkøy ◽  
Jordi Ochando ◽  
Linda Sønstevold ◽  
Maria Hegvik ◽  
...  
Keyword(s):  
Inflammatory Lesions ◽  
Lipid Nanoparticle

scholarly journals Inflammatory Lesions: Cyclic Arginine–Glycine–Aspartate‐Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes (Adv. Sci. 13/2021)

2021 ◽  
Vol 8 (13) ◽  
pp. 2170077
Author(s):  
Alexandros Marios Sofias ◽  
Geir Bjørkøy ◽  
Jordi Ochando ◽  
Linda Sønstevold ◽  
Maria Hegvik ◽  
...  
Keyword(s):  
Inflammatory Lesions ◽  
Lipid Nanoparticle

Use of Protein a Conjugated to Peroxidase to Localize Immunoglobulin G in SSPE Ferret Brain

1982 ◽  
Vol 40 ◽  
pp. 350-351
Author(s):  
Hannah R. Brown ◽  
Anthony F. Nostro ◽  
Halldor Thormar
Keyword(s):  
Immunoglobulin G ◽  
Human Disease ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Protein A ◽  
Inflammatory Lesions ◽  
Sspe Virus ◽  
Specific Immunoglobulin ◽  
Antibody Titers ◽  
The Brain

Subacute sclerosing panencephalitis (SSPE) is a slowly progressing disease of the CNS in children which is caused by measles virus. Ferrets immunized with measles virus prior to inoculation with the cell associated, syncytiogenic D.R. strain of SSPE virus exhibit characteristics very similar to the human disease. Measles virus nucleocapsids are present, high measles antibody titers are found in the sera and inflammatory lesions are prominent in the brains. Measles virus specific immunoglobulin G (IgG) is present in the brain,and IgG/ albumin ratios indicate that the antibodies are synthesized within the CNS.

Formulation Development of Tamoxifen Loaded Lipid Nanoparticle by Taguchi (L12 (2 11)) Orthogonal Array Design

2020 ◽  
Vol 16 ◽  
Author(s):  
Poovi Ganesan ◽  
N Damodharan
Keyword(s):  
Orthogonal Array ◽  
Drug Loading ◽  
Optimization Technique ◽  
Pharmaceutical Products ◽  
Water Soluble ◽  
Nanostructured Lipid Carrier ◽  
Orthogonal Array Design ◽  
Formulation Development ◽  
Array Design ◽  
Lipid Nanoparticle

Background: A better understanding of the biopharmaceutical and physicochemical properties of drugs and the pharmaco-technical factors would be of great help for developing pharmaceutical products. But, it is extremely difficult to study the effect of each variable and interaction among them through the conventional approach Objective: To screen the most influential factors affecting the particle size (PS) of lipid nanoparticle (LNPs) (solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC)) for poorly water-soluble BCS class-II drug like tamoxifen (TMX) to improve its oral bioavailability and to reduce its toxicity to tolerable limits using Taguchi (L12 (2 11)) orthogonal array design by applying computer optimization technique. Results: The size of all LNPs formulations prepared as per the experimental design varied between 172 nm and 3880 μm, polydispersity index between 0.033 and 1.00, encapsulation efficiency between 70.8% and 75.7%, and drug loading between 5.84% and 9.68%. The study showed spherical and non-spherical as well as aggregated and non-aggregated LNPs. Besides, it showed no interaction and amorphous form of the drug in LNPs formulation. The Blank NLCs exhibited no cytotoxicity on MCF-7 cells as compared to TMX solution, SLNs (F5) and NLCs (F12) suggests that the cause of cell death is primarily from the effect of TMX present in NLCs. Conclusions: The screening study clearly showed the importance of different individual factors significant effect for the LNPs formulation development and its overall performance in an in-vitro study with minimum experimentation thus saving considerable time, efforts, and resources for further in-depth study.

scholarly journals Lipid Nanoparticle RBD-hFc mRNA Vaccine Protects hACE2 Transgenic Mice against a Lethal SARS-CoV-2 Infection

Nano Letters ◽  
2021 ◽  
Author(s):  
Uri Elia ◽  
Shahar Rotem ◽  
Erez Bar-Haim ◽  
Srinivas Ramishetti ◽  
Gonna Somu Naidu ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Lipid Nanoparticle

scholarly journals Future considerations for the mRNA-lipid nanoparticle vaccine platform

2021 ◽  
Vol 48 ◽  
pp. 65-72
Author(s):  
Botond Z Igyártó ◽  
Sonya Jacobsen ◽  
Sonia Ndeupen
Keyword(s):  
Vaccine Platform ◽  
Lipid Nanoparticle

Acidic pH-induced changes in lipid nanoparticle membrane packing

2021 ◽  
Vol 1863 (8) ◽  
pp. 183627
Author(s):  
Kyoka Koitabashi ◽  
Hiroki Nagumo ◽  
Mizuka Nakao ◽  
Tomoko Machida ◽  
Kohki Yoshida ◽  
...  
Keyword(s):  
Acidic Ph ◽  
Lipid Nanoparticle ◽  
Induced Changes

scholarly journals Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery

Small ◽  
2021 ◽  
pp. 2103025
Author(s):  
Roy Meel ◽  
Sam Chen ◽  
Josh Zaifman ◽  
Jayesh A. Kulkarni ◽  
Xu Ran S. Zhang ◽  
...  
Keyword(s):  
Lipid Nanoparticle ◽  
Lipophilic Prodrug ◽  
Platform Technology
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