Changes in the hyaluronidase-hyaluronic acid system in the kidneys of rabbits with experimental intestitial nephritis

1964 ◽  
Vol 57 (3) ◽  
pp. 277-281
Author(s):  
A. G. Ginetsinskii ◽  
M. G. Zaks ◽  
V. I. Ioffe ◽  
T. V. Krestinskaya ◽  
M. M. Sokolova ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Acid System

scholarly journals DNA‐Grafted Hyaluronic Acid System with Enhanced Injectability and Biostability for Photo‐Controlled Osteoarthritis Gene Therapy

2021 ◽  
pp. 2004793
Author(s):  
Zhijie Chen ◽  
Feng Zhang ◽  
Hongbo Zhang ◽  
Liang Cheng ◽  
Kaizhe Chen ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Acid System

scholarly journals The Hyaluronan-Related Genes HAS2, HYAL1-5, HYALP1 are Associated with Prognosis, Cell Viability and Spheroid Formation Capacity in Ovarian Cancer

2021 ◽  
Author(s):  
Jette Riecks ◽  
Balázs Győrffy ◽  
Ludwig Kiesel ◽  
Alberto Passi ◽  
Davide Vigetti ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Hyaluronic Acid ◽  
Cell Viability ◽  
Cancer Patients ◽  
Cell Phenotype ◽  
Acid System ◽  
Hyaluronan Synthases ◽  
Response To Chemotherapy ◽  
The Impact

Abstract Purpose: Hyaluronan modulates tumor progression, including cell adhesion, cohesion, proliferation and invasion, and the cancer stem cell phenotype. In ovarian cancer, high levels of stromal hyaluronan are associated with poor prognosis. In this work hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-5, HYALP1) were examined with regard to different levels of gene expression and its influence on ovarian cancer patients survival. The impact of a siRNA depletion of hyaluronic acid synthase HAS2 was investigated in vitro.Methods: Using the Kaplan Meier Plotter tool, we investigated the influence of hyaluronic synthesis enzymes on the survival of a collective of 1435 ovarian cancer patients. We studied SKOV3 ovarian cancer cells subjected to HAS2 siRNA or control siRNA treatment in terms of HAS1-3, HYAL2 and HYAL3 mRNA expression. We investigated the ability to form spheroids using the Hanging Drop method and the response to chemotherapy at different concentrations using the MTT Assay. By String analysis, interactions within the enzymes of the hyaluronic acid system and with binding partners were visualized. Results: HAS2 improves cell viability, the capability to form tumor spheroids and has a negative prognostic value regarding overall survival. Lower HAS2 expression and high expression of HYAL2 and HYAL3 favours the survival of ovarian cancer patients. HAS2 knockdown cells and control cells showed a moderate response to in vitro chemotherapy with Taxol, Cisplatin and combinatorial treatment. Conclusion: In conclusion our study shows that the hyaluronic acid system has a relevant influence on the survival of ovarian cancer patients and could therefore be considered as a possible prognostic factor.

scholarly journals Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System

2021 ◽  
pp. 2103189
Author(s):  
Niranjan G. Kotla ◽  
Isma Liza Mohd Isa ◽  
Swetha Rasala ◽  
Secil Demir ◽  
Rajbir Singh ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Hyaluronic Acid ◽  
Acid System ◽  
Gut Barrier ◽  
Barrier Functions

scholarly journals The Hyaluronic Acid System is Intact in Menstrual Endometrial Cells in Women With and Without Endometriosis

2018 ◽  
Vol 26 (1) ◽  
pp. 109-113 ◽  
Author(s):  
Jennifer F. Knudtson ◽  
Jessica E. McLaughlin ◽  
Marlen Tellez Santos ◽  
Peter A. Binkley ◽  
Rajeshwar R. Tekmal ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Acid System ◽  
Endometrial Cells

Healing of Circular Defects in the Rabbit Medial Meniscus Can Occur Spontaneously and Is not Improved by Intra-Articular Hyaluronic Acid

1996 ◽  
Vol 09 (02) ◽  
pp. 60-5 ◽  
Author(s):  
N. Hope ◽  
P. Ghosh ◽  
S. Collier
Keyword(s):  
Hyaluronic Acid ◽  
Medial Meniscus ◽  
Chondroitin Sulphate ◽  
Rabbit Model ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Keratan Sulphate ◽  
Meniscal Healing ◽  
Meniscus Healing ◽  
Made In

SummaryThe aim of this study was to determine the effects of intra-articular hyaluronic acid on meniscal healing. Circular defects, 1.0 mm in diameter, were made in the anterior third of the medial meniscus in rabbits. In one joint, 0.4 ml hyaluronic acid (Healon®) was instilled, and in the contralateral (control) joint, 0.4 ml Ringer’s saline. Four rabbits were killed after four, eight and 12 weeks and the menisci examined histologically. By eight weeks most of the lesions had healed by filling with hyaline-like cartilage. Healing was not improved by hyaluronic acid treatment. The repair tissue stained strongly with alcian blue, and the presence of type II collagen, keratan sulphate, and chondroitin sulphate was demonstrated by immunohistochemical localisation. In contrast to the circular defects, longitudinal incisions made in the medial menisci of a further six rabbits did not show any healing after 12 weeks, indicating that the shape of the lesion largely determined the potential for healing.The effect of hyaluronic acid on meniscal healing was tested in a rabbit model. With one millimeter circular lesions in the medial meniscus, healing by filling with hyalinelike cartilage was not significantly affected by the application of hyaluronic acid intra-articularly at the time of surgery, compared to saline controls, as assessed histologically four, eight and 12 weeks after the operation.

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