scholarly journals Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial‐Membrane‐Coated Nanoparticles

2019 ◽  
Vol 31 (43) ◽  
pp. 1902626 ◽  
Author(s):  
Ravi B. Patel ◽  
Mingzhou Ye ◽  
Peter M. Carlson ◽  
Abigail Jaquish ◽  
Luke Zangl ◽  
...  
Keyword(s):  
Cancer Vaccine ◽  
Bacterial Membrane ◽  
Coated Nanoparticles

Self-Assembly of 4-Vinylbenzoic Acid Layer on the Magnetic Nanoparticles and In Situ Polymerization

2011 ◽  
Vol 391-392 ◽  
pp. 1427-1430
Author(s):  
Guo Lun Zhong ◽  
Ru Yi Bi ◽  
Hong Lei Mao ◽  
Yong Hong Wang ◽  
Jin Bao Xu
Keyword(s):  
Self Assembly ◽  
In Situ Polymerization ◽  
Single Layer ◽  
Hydrophobic Surface ◽  
Good Property ◽  
Functional Polymer ◽  
Coated Nanoparticles ◽  
Magnetite Particles ◽  
20 Nm

A new method for fabrication of core-shell functional polymer coated nanoparticles was proposed in this work. At first the magnetite particles were wrapped with single-layer oleic acid for getting a hydrophobic surface. Then the monomer molecules of 4-vinylbenzoic acid were fabricated onto this layer by self-assembly and finally in-situ polymerization was taken place for obtaining the functional polymer coated nanoparticles with –COOH groups outside. The nanoparticles were characterized by FTIR, TEM, magnetic property, etc. The results showed that the size of the particle was less than 20 nm in diameter and had a very good property of superparamagnetism.

scholarly journals In situ EPR spectroscopy of a bacterial membrane transporter using an expanded genetic code

2021 ◽  
Author(s):  
Anandi Kugele ◽  
Sophie Ketter ◽  
Bjarne Silkenath ◽  
Valentin Wittmann ◽  
Benesh Joseph ◽  
...  
Keyword(s):  
Genetic Code ◽  
Click Chemistry ◽  
Epr Spectroscopy ◽  
Diels Alder ◽  
Membrane Transporter ◽  
Bacterial Membrane ◽  
Expanded Genetic Code ◽  
Living Bacteria

The membrane transporter BtuB is site-directedly spin labelled on the surface of living bacteria via Diels–Alder click chemistry.

Lipid Coated and Chlorin e6 Loaded Calcium Carbonate for Effective In Situ Immunotheraphy of Colorectal Cancer

2020 ◽  
Vol 16 (8) ◽  
pp. 1196-1204
Author(s):  
Wenxin Dai ◽  
Shaoquan Lu ◽  
Wangyuan Zeng ◽  
Dongwon Lee
Keyword(s):  
Colorectal Cancer ◽  
Calcium Carbonate ◽  
Cancer Vaccine ◽  
Inflammatory Responses ◽  
Chlorin E6 ◽  
Strong Immune Response ◽  
Tumor Associated Antigen

Cancer vaccine is well recognized as a novel but effective way for cancer immunotherapy. Especially, the role of dendritic cells (DCs) in antigen presentation properties is critical for the final performance of cancer vaccine. Herein, a lipid (Li) coated calcium carbonate (CC) vehicle (Li/CC) was employed to load chlorin e6 (Ce6) to serve as a potential in situ vaccine (Li/CC-Ce6) for effective immunotherapy of colorectal cancer. It was suggested that the loaded Ce6 within Li/CCCe6 can be activated under laser irradiation. The photodynamic therapy (PDT) of Ce6 was expected to produce reactive oxygen species (ROS) to cause cell death and expose tumor-associated antigen (TAA). In addition, the produced ROS can mimic the inflammatory responses for the recruitment of DC to initiate strong immune response cascade. Moreover, the recruitment of DC can recognize the exposed TAA to stimulate DC for effective vaccination in situ. Results from in vitro and in vivo assays demonstrated the strong ability of this platform to enhance DC vaccination, resulting in promising growth inhibition of both primary and distant tumors.

Herpes Simplex Virus as an in Situ Cancer Vaccine for the Induction of Specific Anti-Tumor Immunity

1999 ◽  
Vol 10 (3) ◽  
pp. 385-393 ◽  
Author(s):  
Masahiro Toda ◽  
Samuel D. Rabkin ◽  
Hidefumi Kojima ◽  
Robert L. Martuza
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Tumor Immunity ◽  
Cancer Vaccine ◽  
Simplex Virus

scholarly journals Structure and Stability of PEG- and Mixed PEG-Layer-Coated Nanoparticles at High Particle Concentrations Studied In Situ by Small-Angle X-Ray Scattering

2017 ◽  
Vol 35 (2) ◽  
pp. 1700319 ◽  
Author(s):  
Florian Schulz ◽  
Johannes Möller ◽  
Felix Lehmkühler ◽  
Andrew J. Smith ◽  
Tobias Vossmeyer ◽  
...  
Keyword(s):  
Small Angle ◽  
X Ray ◽  
Structure And Stability ◽  
High Particle ◽  
Coated Nanoparticles ◽  
X Ray Scattering ◽  
Ray Scattering

scholarly journals Modulating Antibacterial Immunity via Bacterial Membrane-Coated Nanoparticles

Nano Letters ◽  
2015 ◽  
Vol 15 (2) ◽  
pp. 1403-1409 ◽  
Author(s):  
Weiwei Gao ◽  
Ronnie H. Fang ◽  
Soracha Thamphiwatana ◽  
Brian T. Luk ◽  
Jieming Li ◽  
...  
Keyword(s):  
Bacterial Membrane ◽  
Coated Nanoparticles

Supramolecular Assembled Programmable Nanomedicine As In Situ Cancer Vaccine for Cancer Immunotherapy

2021 ◽  
Vol 33 (7) ◽  
pp. 2007293 ◽  
Author(s):  
Yu Zhang ◽  
Sheng Ma ◽  
Xinming Liu ◽  
Yudi Xu ◽  
Jiayu Zhao ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Cancer Vaccine

Interleukin-12 as an in situ cancer vaccine component: a review

2022 ◽  
Author(s):  
Emily M. Cheng ◽  
Noah W. Tsarovsky ◽  
Paul M. Sondel ◽  
Alexander L. Rakhmilevich
Keyword(s):  
Cancer Vaccine ◽  
Interleukin 12 ◽  
Vaccine Component
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