Electrical Detection of DNA Hybridization with Single-Base Specificity Using Transistors Based on CVD-Grown Graphene Sheets

2010 ◽  
Vol 22 (14) ◽  
pp. 1649-1653 ◽  
Author(s):  
Xiaochen Dong ◽  
Yumeng Shi ◽  
Wei Huang ◽  
Peng Chen ◽  
Lain-Jong Li
Keyword(s):  
Dna Hybridization ◽  
Graphene Sheets ◽  
Electrical Detection ◽  
Single Base ◽  
Base Specificity ◽  
Grown Graphene

Surface and electrochemical characterisation of CVD grown graphene sheets

2013 ◽  
Vol 35 ◽  
pp. 26-29 ◽  
Author(s):  
Elo Kibena ◽  
Marek Mooste ◽  
Jekaterina Kozlova ◽  
Margus Marandi ◽  
Väino Sammelselg ◽  
...  
Keyword(s):  
Graphene Sheets ◽  
Grown Graphene ◽  
Electrochemical Characterisation

Label-Free Electrical Detection of DNA Hybridization on Graphene using Hall Effect Measurements: Revisiting the Sensing Mechanism

2013 ◽  
Vol 23 (18) ◽  
pp. 2301-2307 ◽  
Author(s):  
Cheng-Te Lin ◽  
Phan Thi Kim Loan ◽  
Tzu-Yin Chen ◽  
Keng-Ku Liu ◽  
Chang-Hsiao Chen ◽  
...  
Keyword(s):  
Hall Effect ◽  
Dna Hybridization ◽  
Label Free ◽  
Electrical Detection ◽  
Sensing Mechanism ◽  
Hall Effect Measurements

scholarly journals Bioassays Based on Molecular Nanomechanics

2002 ◽  
Vol 18 (4) ◽  
pp. 167-174 ◽  
Author(s):  
Arun Majumdar
Keyword(s):  
Cancer Diagnosis ◽  
Protein Interactions ◽  
Dna Hybridization ◽  
Specific Antigen ◽  
Label Free ◽  
Receptor Ligand ◽  
Single Base ◽  
Ligand Interactions ◽  
Single Base Pair ◽  
Microcantilever Beam

Recent experiments have shown that when specific biomolecular interactions are confined to one surface of a microcantilever beam, changes in intermolecular nanomechanical forces provide sufficient differential torque to bend the cantilever beam. This has been used to detect single base pair mismatches during DNA hybridization, as well as prostate specific antigen (PSA) at concentrations and conditions that are clinically relevant for prostate cancer diagnosis. Since cantilever motion originates from free energy change induced by specific biomolecular binding, this technique is now offering a common platform for label-free quantitative analysis of protein-protein binding, DNA hybridization DNA-protein interactions, and in general receptor-ligand interactions. Current work is focused on developing “universal microarrays” of microcantilever beams for high-throughput multiplexed bioassays.

Sign in / Sign up

Export Citation Format

Share Document