scholarly journals Antibacterial Hydrogels: Injectable and Self‐Healing Hydrogel with Anti‐Bacterial and Anti‐Inflammatory Properties for Acute Bacterial Rhinosinusitis with Micro Invasive Treatment (Adv. Healthcare Mater. 20/2020)

2020 ◽  
Vol 9 (20) ◽  
pp. 2070073
Author(s):  
Zhengming Chen ◽  
Zhengwei Cai ◽  
Chengjing Zhu ◽  
Xianmin Song ◽  
Yanghua Qin ◽  
...  
Keyword(s):  
Self Healing ◽  
Invasive Treatment ◽  
Acute Bacterial Rhinosinusitis ◽  
Anti Inflammatory

scholarly journals Acupuncture for Primary Dysmenorrhea: A Potential Mechanism from an Anti-Inflammatory Perspective

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Wen-Yan Yu ◽  
Liang-Xiao Ma ◽  
Zhou Zhang ◽  
Jie-Dan Mu ◽  
Tian-Yi Sun ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Animal Studies ◽  
Visceral Pain ◽  
Self Healing ◽  
Primary Dysmenorrhea ◽  
Potential Mechanism ◽  
Future Studies ◽  
Anti Inflammatory ◽  
Proinflammatory Factors

The low adverse effects of acupuncture for primary dysmenorrhea (PD), known as one of the most commonly reported gynecological debilitating conditions affecting women’s overall health, have been thus far confirmed. Moreover, it has been increasingly recognized that inflammation is involved in such menstrual cramps, and recent studies have further shown that the anti-inflammatory effects of acupuncture are helpful in its control. This review portrays the role of inflammation in PD pathophysiology, provides evidence from clinical and animal studies on acupuncture for inflammation-induced visceral pain, and reflects on acupuncture-related therapies for dysmenorrhea with regard to their anti-inflammatory characteristics. Further research accordingly needs to be carried out to clarify the effects of acupuncture on proinflammatory factors in PD, particularly chemokines and leukocytes. Future studies on this condition from an anti-inflammatory perspective should be also performed in line with the notion of emphasizing stimulation modes to optimize the clinical modalities of acupuncture. Additionally, the effects and mechanism of more convenient self-healing approaches such as TENS/TEAS for PD should be investigated.

Application of bacteriophage in complex treatment of rinosinusites

2018 ◽  
pp. 51-56
Author(s):  
Al Hariri Mahmoud Jоmaa ◽  
Svitlana Semenenko ◽  
Sergey Zaikov ◽  
Vasyl Popovych
Keyword(s):  
Therapy Group ◽  
Enzyme Linked Immunosorbent Assay ◽  
Nasal Sinus ◽  
Pronounced Increase ◽  
Acute Bacterial Rhinosinusitis ◽  
Anti Inflammatory ◽  
Group 2 ◽  
The City ◽  
Baseline Therapy ◽  
Group 1

Materials and methods: Sixty patients aged 18 to 85 years who were ill with acute bacterial rhinosinusitis were examined. the average age of which was 36 ± 2 years. The research was carried out on the basis of the ENT Department of the City Clinical Emergency Hospital and the Municipal Medical Diagnostic Center of the city of Vinnitsya. All patients were divided into two groups. 30 patients with acute bacterial rhinosinusitis included in the baseline therapy group 1 (group of comparison), which included: systemic antibiotic therapy (selective drugs - cephalosporins II-III generation), anti-inflammatory (topical corticosteroids, non-steroidal anti-inflammatory drugs), irrigation therapy, local decongestants and drugs with mucolytic, secretomotor and secretory effect. Group 2 (main group) consisted of 30 patients with a diagnosis of acute bacterial rhinosinusitis, the bacteriophage (sta- phylococcal or piophage) was added to the baseline therapy. Patients undergoing bacteriophage (staphylococcus or piophage) were injected as drops in the nose, 3-4 drops in each nasal passage three times a day for 7-10 days or after catheterization of the nasal sinus was washed with sterile 0.9% sodium chloride solution, after which was injected through a catheter of 3-5 ml of a bacteriophage into the sinus cavity once a day for 7-10 days. The level of secretory immunoglobulin A (sIgA) was determined using an enzyme-linked immunosorbent assay in nasal secret. The statistical processing of the results was carried out using the statistical computer program Statistica for Windows, v.12 using parametric and nonparametric methods for evaluating the results. Results: Prior to the median treatment, the concentration of sIgA in nasal washes in group 1 was 0.92 mg / L, the interquartile interval of P25-P75 was in the range of 0.74; 1.15 mg / l, and in group 2 - median 0.94 mg / L, P25-P75 - 0.75-1.10 mg / l (p> 0.05). It was found that standard therapy was accompanied by a probable increase The concentration of sIgA in the nasal secret in 7-10 days from the beginning of treatment was 2.1 times (p <0.001), compared to the indicator before treatment, while the rates before treatment and after 12 weeks were not statistically significantly different (p = 0.051). Against the background of combination therapy, which included a bacteriophage, there was a more pronounced increase in the level of sIgA - after 7-10 days in 3 times (p <0,001), in 12 weeks in 2,5 times (p <0,001), compared with the indicator before treatment. A comparison of the mean values of sIgA concentration in the nasal secret between the study groups revealed that in 7-10 days and 12 weeks, the concentration of sIgA in patients receiving a bacteriophage was 21.3% and 43.9% higher, respectively, than in patients in the base group therapy (p = 0.048 and p <0.001). It was established that modified therapy with the use of bacteriophage contributes to the prevention of chronic acute bacterial rhinosinusitis, which was 36.6% less frequent than in the basic therapy group without bacteriophage (CS: 0.18; 95% CI: [0.05-0, 58]).

In situ mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis

2021 ◽  
Author(s):  
Weifeng Shao ◽  
Rui Chen ◽  
Gaolong Lin ◽  
Kunjie Ran ◽  
Yingying Zhang ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Oral Mucositis ◽  
The Self ◽  
Temperature Sensitive ◽  
Self Healing ◽  
Severe Inflammation ◽  
Anti Inflammatory ◽  
Repairing Effect

The self-healing of chemotherapy-induced oral mucositis was difficultly practiced because of both local bacterial infection and severe inflammation. Herein, in situ mucoadhesive hydrogels (PPP_E) was successfully prepared by using temperature-sensitive...

Autonomous self-healing polyisoprene elastomers with high modulus and good toughness based on the synergy of dynamic ionic crosslinks and highly disordered crystals

2020 ◽  
Vol 11 (41) ◽  
pp. 6549-6558
Author(s):  
Yohei Miwa ◽  
Mayu Yamada ◽  
Yu Shinke ◽  
Shoichi Kutsumizu
Keyword(s):  
Mechanical Properties ◽  
Room Temperature ◽  
Self Healing ◽  
High Modulus ◽  
Disordered Crystals ◽  
Ionic Crosslinks

We designed a novel polyisoprene elastomer with high mechanical properties and autonomous self-healing capability at room temperature facilitated by the coexistence of dynamic ionic crosslinks and crystalline components that slowly reassembled.

Congenital self-healing histiocytosis

1982 ◽  
Vol 118 (4) ◽  
pp. 267-272 ◽  
Author(s):  
E. Bonifazi
Keyword(s):  
Self Healing
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