scholarly journals Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of Mg2+/curcumin from injectable self-healing hydrogels

Theranostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 5911-5925
Author(s):  
Baojun Chen ◽  
Yongping Liang ◽  
Jing Zhang ◽  
Lang Bai ◽  
Meiguang Xu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Bone Healing ◽  
Self Healing ◽  
Synergistic Enhancement ◽  
Anti Inflammatory

Formulation and Evaluation of Atorvastatin Calcium-Poly-ε-Caprolactone Nanoparticles Loaded Ocular Inserts for Sustained Release and Antiinflammatory Efficacy

2020 ◽  
Vol 21 (15) ◽  
pp. 1688-1698
Author(s):  
Germeen N.S. Girgis
Keyword(s):  
Sustained Release ◽  
In Vitro Release ◽  
Pluronic F127 ◽  
In Vivo Study ◽  
Average Weight ◽  
Drug Release Profile ◽  
Atorvastatin Calcium ◽  
Anti Inflammatory

Purpose: The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. Methods: First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanoparticles were loaded within inserts formulated with Methylcellulose (MC) and Polyvinyl Alcohol (PVA) by a solvent casting technique and evaluated physically, for in-vitro drug release profile. Finally, an in-vivo study was performed on the selected formulation to prove non-irritability and sustained ocular anti-inflammatory efficacy compared with free drug-loaded ocuserts. Results: The results revealed (ATC-PCL) nanoparticles prepared with 0.5% pluronic F127 were optimized with 181.72±3.6 nm particle size, 0.12±0.02 (PDI) analysis, -27.4± 0.69 mV zeta potential and 62.41%±4.7% entrapment efficiency. Nanoparticles loaded ocuserts manifested compatibility between drug and formulation polymers. Moreover, formulations complied with average weight 0.055±0.002 to 0.143±0.023 mg, and accepted pH. ATC-PCL nanoparticles loaded inserts prepared by 5% MC showed more sustained, prolonged in-vitro release over 24h. In-vivo study emphasized non-irritability, ocular anti-inflammatory effectiveness represented by smaller lid closure scores, and statistically significant lowering in PMN count after 3h. Conclusion: These findings proposed a possibly simple, new and affordable price technique to prepare promising (ATC-PCL) nanoparticles loaded inserts to achieve sustained release with prolonged antiinflammatory efficacy.

scholarly journals Acupuncture for Primary Dysmenorrhea: A Potential Mechanism from an Anti-Inflammatory Perspective

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Wen-Yan Yu ◽  
Liang-Xiao Ma ◽  
Zhou Zhang ◽  
Jie-Dan Mu ◽  
Tian-Yi Sun ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Animal Studies ◽  
Visceral Pain ◽  
Self Healing ◽  
Primary Dysmenorrhea ◽  
Potential Mechanism ◽  
Future Studies ◽  
Anti Inflammatory ◽  
Proinflammatory Factors

The low adverse effects of acupuncture for primary dysmenorrhea (PD), known as one of the most commonly reported gynecological debilitating conditions affecting women’s overall health, have been thus far confirmed. Moreover, it has been increasingly recognized that inflammation is involved in such menstrual cramps, and recent studies have further shown that the anti-inflammatory effects of acupuncture are helpful in its control. This review portrays the role of inflammation in PD pathophysiology, provides evidence from clinical and animal studies on acupuncture for inflammation-induced visceral pain, and reflects on acupuncture-related therapies for dysmenorrhea with regard to their anti-inflammatory characteristics. Further research accordingly needs to be carried out to clarify the effects of acupuncture on proinflammatory factors in PD, particularly chemokines and leukocytes. Future studies on this condition from an anti-inflammatory perspective should be also performed in line with the notion of emphasizing stimulation modes to optimize the clinical modalities of acupuncture. Additionally, the effects and mechanism of more convenient self-healing approaches such as TENS/TEAS for PD should be investigated.

Transforming sustained release into on-demand release: self-healing guanosine–borate supramolecular hydrogels with multiple responsiveness for Acyclovir delivery

2020 ◽  
Vol 8 (22) ◽  
pp. 6190-6203
Author(s):  
Cheng-guang Wu ◽  
Xiang Wang ◽  
Yun-feng Shi ◽  
Bin-cheng Wang ◽  
Wei Xue ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Release Kinetics ◽  
Self Healing ◽  
On Demand

Supramolecular hydrogels derived from natural nucleoside have promising applications for on-demand drug release with controlled on/off switch and adjustable release kinetics in response to various stimuli.

Non-steroidal anti-inflammatory drugs inhibit bone healing: A review

2010 ◽  
Vol 23 (06) ◽  
pp. 385-392 ◽  
Author(s):  
S. Barry
Keyword(s):  
Animal Models ◽  
Heterotopic Ossification ◽  
Mechanism Of Action ◽  
Bone Healing ◽  
Clinical Importance ◽  
Human Medicine ◽  
Experimental Animal Models ◽  
Domestic Species ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryThe ability of non-steroidal anti-inflammatory drugs (NSAID) to inhibit bone healing has been established in experimental animal models using mice, rats, and rabbits. The mechanism of action is largely unknown but stems from prostaglandin inhibition and is likely multifactorial. In human medicine NSAID are known to prevent heterotopic ossification, however the clinical importance of their effects on bone healing remains controversial. Although a small handful of reports suggest that NSAID suppress bone healing in dogs and horses, there is little published information to direct veterinary practice in domestic species.

Effect of steroidal saponins-loaded nano-bioglass/phosphatidylserine/collagen bone substitute on bone healing

2017 ◽  
Vol 62 (5) ◽  
Author(s):  
Chunrong Yang ◽  
Huazhong Wu ◽  
Jianhua Wang
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Porous Structure ◽  
Bone Healing ◽  
Bone Substitute ◽  
Therapeutic Potential ◽  
Steroidal Saponins ◽  
Skeletal Defects ◽  
Collagen Microsphere

AbstractThe objective of this study was to investigate the therapeutic potential of nano-bioglass/phosphatidylserine/collagen (nBG/PS/COL) scaffolds loaded with steroidal saponins as an inducer factor for skeletal defects. The drugs-encapsulated bone substitute was prepared by loading steroidal saponins-collagen microsphere suspension in nano-bioglass and phosphatidylserine (PS) composite. The scaffolds possess an interconnected porous structure with a porosity of about 82.3%. The pore size ranges from several micrometers up to about 400 μm. The drug release assays showed the long-term sustained release of steroidal saponins from the scaffolds with effective and safe bioactivity. Moreover,

scholarly journals Evaluation of a Topical Herbal Agent for the Promotion of Bone Healing

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Wing-Sum Siu ◽  
Chun-Hay Ko ◽  
Ka-Wing Lam ◽  
Elaine Wat ◽  
Wai-Ting Shum ◽  
...  
Keyword(s):  
Bone Healing ◽  
Bone Cells ◽  
Drill Hole ◽  
Treatment Area ◽  
Hole Defect ◽  
Anti Inflammatory ◽  
Turnover Markers ◽  
Healing Bone

A topically used Chinese herbal paste, namely, CDNR, was designed to facilitate fracture healing which is usually not addressed in general hospital care. From ourin vitrostudies, CDNR significantly inhibited the release of nitric oxide from RAW264.7 cells by 51 to 77%. This indicated its anti-inflammatory effect. CDNR also promoted the growth of bone cells by stimulating the proliferation of UMR106 cells up to 18%. It also increased the biomechanical strength of the healing bone in a drill-hole defect rat model by 16.5% significantly. This result revealed itsin vivoefficacy on facilitation of bone healing. Furthermore, the detection of the chemical markers of CDNR in the skin and muscle of the treatment area demonstrated its transdermal properties. However, CDNR did not affect the bone turnover markers in serum of the rats. With its anti-inflammatory and bone formation properties, CDNR is found effective in promoting bone healing.

Sign in / Sign up

Export Citation Format

Share Document