In situ mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis

2021 ◽  
Author(s):  
Weifeng Shao ◽  
Rui Chen ◽  
Gaolong Lin ◽  
Kunjie Ran ◽  
Yingying Zhang ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Oral Mucositis ◽  
The Self ◽  
Temperature Sensitive ◽  
Self Healing ◽  
Severe Inflammation ◽  
Anti Inflammatory ◽  
Repairing Effect

The self-healing of chemotherapy-induced oral mucositis was difficultly practiced because of both local bacterial infection and severe inflammation. Herein, in situ mucoadhesive hydrogels (PPP_E) was successfully prepared by using temperature-sensitive...

scholarly journals Self-Healing EPDM Rubbers with Highly Stable and Mechanically-Enhanced Urea-Formaldehyde (UF) Microcapsules Prepared by Multi-Step In Situ Polymerization

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1918 ◽  
Author(s):  
Hyeong-Jun Jeoung ◽  
Kun Won Kim ◽  
Yong Jun Chang ◽  
Yong Chae Jung ◽  
Hyunchul Ku ◽  
...  
Keyword(s):  
Mechanical Stability ◽  
In Situ Polymerization ◽  
Urea Formaldehyde ◽  
Testing Machine ◽  
Optical Microscope ◽  
The Self ◽  
Self Healing ◽  
Grubbs Catalyst ◽  
Healing Efficiency

The mechanically-enhanced urea-formaldehyde (UF) microcapsules are developed through a multi-step in situ polymerization method. Optical microscope (OM) and field emission scanning electron microscope (FE-SEM) prove that the microcapsules, 147.4 μm in diameter with a shell thickness of 600 nm, are well-formed. From 1H-nuclear magnetic resonance (1H-NMR) analysis, we found that dicyclopentadiene (DCPD), a self-healing agent encapsulated by the microcapsules, occupies ca. 40.3 %(v/v) of the internal volume of a single capsule. These microcapsules are mixed with EPDM (ethylene-propylene-diene-monomer) and Grubbs’ catalyst via a solution mixing method, and universal testing machine (UTM) tests show that the composites with mechanically-enhanced microcapsules has ca. 47% higher toughness than the composites with conventionally prepared UF microcapsules, which is attributed to the improved mechanical stability of the microcapsule. When the EPDM/microcapsule rubber composites are notched, Fourier-transform infrared (FT-IR) spectroscopy shows that DCPD leaks from the broken microcapsule to the damaged site and flows to fill the notched valley, and self-heals as it is cured by Grubbs’ catalyst. The self-healing efficiency depends on the capsule concentration in the EPDM matrix. However, the self-healed EPDM/microcapsule rubber composite with over 15 wt% microcapsule shows an almost full recovery of the mechanical strength and 100% healing efficiency.

scholarly journals Maleimide Self-Reaction in Furan/Maleimide-Based Reversibly Crosslinked Polyketones: Processing Limitation or Potential Advantage?

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2230
Author(s):  
Felipe Orozco ◽  
Zafarjon Niyazov ◽  
Timon Garnier ◽  
Nicola Migliore ◽  
Alexander Zdvizhkov ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Polymer System ◽  
Side Reaction ◽  
The Self ◽  
The Other ◽  
Side Reactions ◽  
Thermal Treatments ◽  
Self Healing ◽  
Do So

Polymers crosslinked via furan/maleimide thermo-reversible chemistry have been extensively explored as reprocessable and self-healing thermosets and elastomers. For such applications, it is important that the thermo-reversible features are reproducible after many reprocessing and healing cycles. Therefore, side reactions are undesirable. However, we have noticed irreversible changes in the mechanical properties of such materials when exposing them to temperatures around 150 °C. In this work, we study whether these changes are due to the self-reaction of maleimide moieties that may take place at this rather low temperature. In order to do so, we prepared a furan-grafted polyketone crosslinked with the commonly used aromatic bismaleimide (1,1′-(methylenedi-4,1-phenylene)bismaleimide), and exposed it to isothermal treatments at 150 °C. The changes in the chemistry and thermo-mechanical properties were mainly studied by infrared spectroscopy, 1H-NMR, and rheology. Our results indicate that maleimide self-reaction does take place in the studied polymer system. This finding comes along with limitations over the reprocessing and self-healing procedures for furan/maleimide-based reversibly crosslinked polymers that present their softening (decrosslinking) point at relatively high temperatures. On the other hand, the side reaction can also be used to tune the properties of such polymer products via in situ thermal treatments.

scholarly journals A Self-healing Hydrogel Electrolyte Towards All-in-one Flexible Supercapacitors

2021 ◽  
Author(s):  
Wen-Bin Ma ◽  
Ke-Hu Zhu ◽  
Shi-Fang Ye ◽  
Yao Wang ◽  
Lin Guo ◽  
...  
Keyword(s):  
Electrode Materials ◽  
Mechanical Performance ◽  
In Situ Polymerization ◽  
The Self ◽  
Poly Vinyl Alcohol ◽  
Physical Interaction ◽  
Self Healing ◽  
Wearable Electronics ◽  
Pva Hydrogel

Abstract The autonomously self-healable all-in-one supercapacitor is prepared by in situ rapid polymerization of electrode materials on the surface of self-healing poly (vinyl alcohol) (PVA) hydrogel electrolyte containing sulphuric acid (H2SO4). The self-healing PVA electrolyte has been achieved by physical interaction, in which dynamic hydrogen bonds between PVA chains can readily break and reform, allowing PVA hydrogel electrolyte to self-heal and regain its mechanical and electrochemical properties. The obtained PVA hydrogel displays fast self-healing capability, reliable mechanical performance (stress at 290 KPa after stretching to 238 %) and high ionic conductivity (57.8 mS cm− 1). Based on these excellent properties, an all-in-one supercapacitor with self-healing characteristics is assembled by in situ polymerization of aniline on the surface of self-healable PVA electrolyte. The self-healable all-in-one supercapacitor exhibits specific capacitance 470 mF cm− 2 at current density of 0.2 mA cm− 2 and energy density 32 µWh cm− 2 at power density 100 µW cm− 2. The broken device can be repaired itself and there is a 63% capacitance retention for the healable supercapacitor. This self-healing supercapacitor will promote the development of self-healing energy storage devices in wearable electronics.

Self-Sensing and Self-Healing of Structural Damage in Fiber Reinforced Composites

2013 ◽  
Author(s):  
Yingtao Liu ◽  
Abhishek Rajadas ◽  
Aditi Chattopadhyay
Keyword(s):  
Structural Damage ◽  
The Self ◽  
Fiber Reinforced Composites ◽  
Self Healing ◽  
Reinforced Composites ◽  
Fiber Reinforced ◽  
Matrix Cracks ◽  
The Matrix ◽  
Carbon Fiber Reinforced Composites

Carbon fiber reinforced composites have been used in a wide range of applications in aerospace, mechanical, and civil structures. Due to the nature of material, multiple types of structural damage including micro matrix cracks and delaminations can significant degrade the integrity and safety of composites. It is difficult to detect and repair such damage since they are always barely visible to the naked eye. This paper presents the development of self-sensing and self-healing functions in order to detect damage progression and conduct in-situ damage repair in composite structures. Carbon nanotubes, which are highly conductive materials, are uniformly distributed within epoxy to develop the self-sensing capability. Shape memory polymer is used in the hot spot to obtain the self-healing capability. The developed multi-functional material is applied to carbon fiber reinforced composites for the autonomic detection and heal the matrix cracking. Experimental results showed that the developed composite materials are capable of detecting and healing the matrix cracks and delaminations. The developed self-healing material has the potential to be used as a novel structural material in mechanical, civil, aerospace applications. It can be used to detect and in-situ repair matrix damage induced by low velocity impacts and fatigues.

scholarly journals A self-healing catalyst for electrocatalytic and photoelectrochemical oxygen evolution in highly alkaline conditions

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Chao Feng ◽  
Faze Wang ◽  
Zhi Liu ◽  
Mamiko Nakabayashi ◽  
Yequan Xiao ◽  
...  
Keyword(s):  
Oxygen Evolution ◽  
The Self ◽  
Self Healing ◽  
Ferrous Ions ◽  
Nickel Iron ◽  
Long Term Stability ◽  
Alkaline Conditions ◽  
Double Hydroxides

AbstractWhile self-healing is considered a promising strategy to achieve long-term stability for oxygen evolution reaction (OER) catalysts, this strategy remains a challenge for OER catalysts working in highly alkaline conditions. The self-healing of the OER-active nickel iron layered double hydroxides (NiFe-LDH) has not been successful due to irreversible leaching of Fe catalytic centers. Here, we investigate the introduction of cobalt (Co) into the NiFe-LDH as a promoter for in situ Fe redeposition. An active borate-intercalated NiCoFe-LDH catalyst is synthesized using electrodeposition and shows no degradation after OER tests at 10 mA cm−2 at pH 14 for 1000 h, demonstrating its self-healing ability under harsh OER conditions. Importantly, the presence of both ferrous ions and borate ions in the electrolyte is found to be crucial to the catalyst’s self-healing. Furthermore, the implementation of this catalyst in photoelectrochemical devices is demonstrated with an integrated silicon photoanode. The self-healing mechanism leads to a self-limiting catalyst thickness, which is ideal for integration with photoelectrodes since redeposition is not accompanied by increased parasitic light absorption.

Enhanced drug loading of in situ forming gels for oral mucositis pain control

2021 ◽  
Vol 595 ◽  
pp. 120225
Author(s):  
Tingting Li ◽  
Rajesh V. Lalla ◽  
Diane J. Burgess
Keyword(s):  
Oral Mucositis ◽  
Pain Control ◽  
Drug Loading ◽  
In Situ Forming
Sign in / Sign up

Export Citation Format

Share Document