Delivering Proangiogenic Factors from 3D‐Printed Polycaprolactone Scaffolds for Vascularized Bone Regeneration

2020 ◽  
Vol 9 (23) ◽  
pp. 2000727
Author(s):  
Haoming Liu ◽  
Yingying Du ◽  
Gaojie Yang ◽  
Xixi Hu ◽  
Lin Wang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
3D Printed ◽  
Vascularized Bone

scholarly journals 3D Printed Wesselsite Nanosheets Functionalized Scaffold Facilitates NIR‐II Photothermal Therapy and Vascularized Bone Regeneration

2021 ◽  
pp. 2100894
Author(s):  
Chen Yang ◽  
Hongshi Ma ◽  
Zhiyong Wang ◽  
Muhammad Rizwan Younis ◽  
Chunyang Liu ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Photothermal Therapy ◽  
3D Printed ◽  
Vascularized Bone

3D-printed scaffolds with synergistic effect of hollow-pipe structure and bioactive ions for vascularized bone regeneration

Biomaterials ◽  
2017 ◽  
Vol 135 ◽  
pp. 85-95 ◽  
Author(s):  
Wenjie Zhang ◽  
Chun Feng ◽  
Guangzheng Yang ◽  
Guanglong Li ◽  
Xun Ding ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Bone Regeneration ◽  
3D Printed ◽  
Vascularized Bone

scholarly journals Vascularized Bone Regeneration Accelerated by 3D-Printed Nanosilicate-Functionalized Polycaprolactone Scaffold

2021 ◽  
Author(s):  
Xiongcheng Xu ◽  
Long Xiao ◽  
Yanmei Xu ◽  
Jin Zhuo ◽  
Xue Yang ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Regeneration ◽  
Bone Repair ◽  
Cytokine Secretion ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed ◽  
Vascularized Bone

Abstract Critical oral-maxillofacial bone defects, damaged by trauma and tumors, not only affect the physiological functions and mental health of patients but are also highly challenging to reconstruct. Personalized biomaterials customized by 3D printing technology have the potential to match oral-maxillofacial bone repair and regeneration requirements. Laponite nanosilicates have been added to biomaterials to achieve biofunctional modification owing to their excellent biocompatibility and bioactivity. Herein, porous nanosilicate-functionalized polycaprolactone (PCL/LAP) was fabricated by 3D printing technology, and its bioactivities in bone regeneration were investigated in vitro and in vivo. In vitro experiments demonstrated that PCL/LAP exhibited good cytocompatibility and enhanced the viability of BMSCs. PCL/LAP functioned to stimulate osteogenic differentiation of BMSCs at the mRNA and protein levels and elevated angiogenic gene expression and cytokine secretion. Moreover, BMSCs cultured on PCL/LAP promoted the angiogenesis potential of endothelial cells by angiogenic cytokine secretion. Then, PCL/LAP scaffolds were implanted into the calvarial defect model. Toxicological safety of PCL/LAP was confirmed, and significant enhancement of vascularized bone formation was observed. Taken together, 3D-printed PCL/LAP scaffolds with brilliant osteogenesis to enhance bone regeneration could be envisaged as an outstanding bone substitute for a promising change in oral-maxillofacial bone defect reconstruction.

Construction of a nanofiber network within 3D printed scaffolds for vascularized bone regeneration

2021 ◽  
Vol 9 (7) ◽  
pp. 2631-2646
Author(s):  
Mengru Geng ◽  
Qianqian Zhang ◽  
Jiani Gu ◽  
Jin Yang ◽  
Haibo Du ◽  
...  
Keyword(s):  
Cell Growth ◽  
Bone Formation ◽  
Bone Regeneration ◽  
Cell Growth And Migration ◽  
3D Printed ◽  
And Migration ◽  
Vascularized Bone

3D printed scaffolds with micro and nano architectures that facilitate cell growth and migration were prepared, and the scaffolds allowed deferoxamine release to accelerate bone formation.

Copper peptide-incorporated 3D-printed silk-based scaffolds promote vascularized bone regeneration

2021 ◽  
pp. 130147
Author(s):  
Mingliang Zhou ◽  
Xiaolin Wu ◽  
Jiaxin Luo ◽  
Guangzheng Yang ◽  
Yuezhi Lu ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
3D Printed ◽  
Vascularized Bone
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