Highly Stable and Long‐Circulating Metal‐Organic Frameworks Nanoprobes for Sensitive Tumor Detection In Vivo

2019 ◽  
Vol 8 (19) ◽  
pp. 1900761 ◽  
Author(s):  
Ruili Zhang ◽  
Chaoqiang Qiao ◽  
Qian Jia ◽  
Yongdong Wang ◽  
Huimin Huang ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Tumor Detection ◽  
Metal Organic

In depth analysis of the in vivo toxicity of nanoparticles of porous iron(iii) metal–organic frameworks

2013 ◽  
Vol 4 (4) ◽  
pp. 1597 ◽  
Author(s):  
Tarek Baati ◽  
Leila Njim ◽  
Fadoua Neffati ◽  
Abdelhamid Kerkeni ◽  
Muriel Bouttemi ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Porous Iron ◽  
In Vivo Toxicity ◽  
Depth Analysis ◽  
Metal Organic

scholarly journals A Simple in vivo Assay Using Amphipods for the Evaluation of Potential Biocompatible Metal-Organic Frameworks

2021 ◽  
Vol 9 ◽  
Author(s):  
Ines Sifaoui ◽  
Idaira Pacheco-Fernández ◽  
José E. Piñero ◽  
Verónica Pino ◽  
Jacob Lorenzo-Morales
Keyword(s):  
Ex Vivo ◽  
Colorimetric Assay ◽  
Metal Organic Frameworks ◽  
Screening Method ◽  
Toxicity Tests ◽  
Toxicity Screening ◽  
Metal Organic ◽  
Potential Use

In this study, the application of amphipods in vivo assays was evaluated. The main aim of this work was to check the potential use of this model in biocompatibility assessments of metal-organic frameworks (MOFs). Hence, six different MOFs were synthesized and the in vitro and ex vivo cytotoxicity was first assessed using a colorimetric assay and a macrophage cell line. Obtained results were compared to validate the in vivo toxicity tests carried out using amphipods and increasing concentrations of the different MOFs. Amphipods do not require the need of ethics approval and also are less expensive to keep than conventional in vivo models, showing its potential as a fast and reliable platform in toxicity studies. The obtained results showed that the amphipods based-assay was simple, easy to replicate and yielded toxicity data corresponding to the type of MOFs tested. In addition, it was observed that only CIM-80(Al) and CIM-84(Zr) did not show any toxicity to the animals at the different tested concentrations. Therefore, the developed in vivo model could be applied as a high-throughput toxicity screening method to evaluate the toxicity of numerous materials, chemicals and therapeutic agents among others.

Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

2018 ◽  
Vol 30 (37) ◽  
pp. 1707365 ◽  
Author(s):  
Teresa Simon-Yarza ◽  
Angelika Mielcarek ◽  
Patrick Couvreur ◽  
Christian Serre
Keyword(s):  
Metal Organic Frameworks ◽  
In Vivo Efficacy ◽  
The Road ◽  
Metal Organic ◽  
On The Road

scholarly journals Drug Delivery: Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine (Adv. Mater. 37/2018)

2018 ◽  
Vol 30 (37) ◽  
pp. 1870281 ◽  
Author(s):  
Teresa Simon-Yarza ◽  
Angelika Mielcarek ◽  
Patrick Couvreur ◽  
Christian Serre
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
In Vivo Efficacy ◽  
The Road ◽  
Metal Organic ◽  
On The Road

ZIF-8 Degrades in Cell Media, Serum, and Some—But Not All—Common Laboratory Buffers

2019 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Michael W. Gaertner ◽  
Hamilton lee ◽  
Fabian C. Herbert ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
The Other ◽  
Blood Proteins ◽  
Time Resolved ◽  
Rational Explanation ◽  
Metal Organic ◽  
Release Data ◽  
Common Laboratory

<p>The emergence of drug delivery using water stable metal-organic frameworks has elicited a lot of interest in their biocompatibility. However, few studies have been conducted on their stability in common buffers, cell media, and blood proteins. For these studies, single crystal ZIF-8 approximately 1 um in diameter were synthesized, incubated with common laboratory buffers, cell media, and serum, and then characterized by PXRD, IR, DLS, and SEM. Time-resolved SEM and PXRD demonstrate that buffers containing phosphate and bicarbonate alter the appearance and composition of ZIF-8. Further, blood proteins in serum dissolve ZIF-8, causing trapped biomolecules to escape. The study presented here suggests that ZIF-8 can undergo dramatic surface chemistry changes that may affect the interpretation of cellular uptake and cargo release data. On the other hand, it provides a rational explanation as to how ZIF-8 neatly dissolves <i>in vivo</i>. </p>

Size and surface controllable metal–organic frameworks (MOFs) for fluorescence imaging and cancer therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (13) ◽  
pp. 6205-6211 ◽  
Author(s):  
Xuechuan Gao ◽  
Ruixue Cui ◽  
Guanfeng Ji ◽  
Zhiliang Liu
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Anti Cancer ◽  
Metal Organic ◽  
Organic Framework

This work presents a novel size and surface controllable metal–organic framework, UIO-66-NH2-FA-5-FAM/5-FU, which possesses the superior characteristics of targeted identification of cancer cells, bioimaging and obvious anti-cancer effects in vivo.

Metal-Organic Frameworks

2021 ◽  
pp. 171-183
Author(s):  
Marcus Vinícius Dias-Souza ◽  
Cleiton Gonçalves Dias
Keyword(s):  
Drug Delivery Systems ◽  
Metal Organic Frameworks ◽  
Bioinorganic Chemistry ◽  
Loading Capacity ◽  
Clinical Use ◽  
Metal Centers ◽  
Control Drug ◽  
Metal Organic ◽  
Control Drug Release

In the field of bioinorganic chemistry, porosity has been explored for the development of metal-organic frameworks (MOFs), innovative polymers, or networks composed of metal centers that stabilize organic molecules with high contact surface and well-defined crystalline structures. MOFs have also been investigated for drug therapies due to their high loading capacity, thermal stability, low electrical conductivity, biodegradability, biocompatibility, easy functionalization, and size considered adequate to control drug release in vivo. MOFs can be sensitive to variations in pH, magnetism, temperature, pressure, light, and humidity, making them desirable for vectorizing extended release systems. Among the most investigated pharmacological groups for association with MOFs are anti-inflammatory and antineoplasic drugs. Here the authors explore the recent advances of MOFs-based drug delivery systems, their current limitations, and discuss the evidences towards their potential clinical use.

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