scholarly journals Drug Delivery: Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine (Adv. Mater. 37/2018)

2018 ◽  
Vol 30 (37) ◽  
pp. 1870281 ◽  
Author(s):  
Teresa Simon-Yarza ◽  
Angelika Mielcarek ◽  
Patrick Couvreur ◽  
Christian Serre
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
In Vivo Efficacy ◽  
The Road ◽  
Metal Organic ◽  
On The Road

Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

2018 ◽  
Vol 30 (37) ◽  
pp. 1707365 ◽  
Author(s):  
Teresa Simon-Yarza ◽  
Angelika Mielcarek ◽  
Patrick Couvreur ◽  
Christian Serre
Keyword(s):  
Metal Organic Frameworks ◽  
In Vivo Efficacy ◽  
The Road ◽  
Metal Organic ◽  
On The Road

ZIF-8 Degrades in Cell Media, Serum, and Some—But Not All—Common Laboratory Buffers

2019 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Michael W. Gaertner ◽  
Hamilton lee ◽  
Fabian C. Herbert ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
The Other ◽  
Blood Proteins ◽  
Time Resolved ◽  
Rational Explanation ◽  
Metal Organic ◽  
Release Data ◽  
Common Laboratory

<p>The emergence of drug delivery using water stable metal-organic frameworks has elicited a lot of interest in their biocompatibility. However, few studies have been conducted on their stability in common buffers, cell media, and blood proteins. For these studies, single crystal ZIF-8 approximately 1 um in diameter were synthesized, incubated with common laboratory buffers, cell media, and serum, and then characterized by PXRD, IR, DLS, and SEM. Time-resolved SEM and PXRD demonstrate that buffers containing phosphate and bicarbonate alter the appearance and composition of ZIF-8. Further, blood proteins in serum dissolve ZIF-8, causing trapped biomolecules to escape. The study presented here suggests that ZIF-8 can undergo dramatic surface chemistry changes that may affect the interpretation of cellular uptake and cargo release data. On the other hand, it provides a rational explanation as to how ZIF-8 neatly dissolves <i>in vivo</i>. </p>

Liposomes as colloidal nanovehicles: on the road to success in intravenous drug delivery

2018 ◽  
Vol 34 (3) ◽  
pp. 365-383 ◽  
Author(s):  
Sumaira Naeem ◽  
Geetha Viswanathan ◽  
Misni Bin Misran
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Colloidal Systems ◽  
Triggered Release ◽  
The Road ◽  
On The Road

AbstractThe advancement of research in colloidal systems has led to the increased application of this technology in more effective and targeted drug delivery. Nanotechnology enables control over functionality parameters and allows innovations in biodegradable, biocompatible, and stimuli-responsive delivery systems. The first closed bilayer phospholipid system, the liposome system, has been making steady progress over five decades of extensive research and has been efficient in achieving many desirable parameters such as remote drug loading, size-controlling measures, longer circulation half-lives, and triggered release. Liposome-mediated drug delivery has been successful in overcoming obstacles to cellular and tissue uptake of drugs with improved biodistributionin vitroandin vivo. These colloidal nanovehicles have moved on from a mere concept to clinical applications in various drug delivery systems for antifungal, antibiotic, and anticancer drugs.

ZIF-8 Degrades in Cell Media, Serum, and Some—But Not All—Common Laboratory Buffers

2019 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Michael W. Gaertner ◽  
Hamilton lee ◽  
Fabian C. Herbert ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
The Other ◽  
Blood Proteins ◽  
Time Resolved ◽  
Rational Explanation ◽  
Metal Organic ◽  
Release Data ◽  
Common Laboratory

<p>The emergence of drug delivery using water stable metal-organic frameworks has elicited a lot of interest in their biocompatibility. However, few studies have been conducted on their stability in common buffers, cell media, and blood proteins. For these studies, single crystal ZIF-8 approximately 1 um in diameter were synthesized, incubated with common laboratory buffers, cell media, and serum, and then characterized by PXRD, IR, DLS, and SEM. Time-resolved SEM and PXRD demonstrate that buffers containing phosphate and bicarbonate alter the appearance and composition of ZIF-8. Further, blood proteins in serum dissolve ZIF-8, causing trapped biomolecules to escape. The study presented here suggests that ZIF-8 can undergo dramatic surface chemistry changes that may affect the interpretation of cellular uptake and cargo release data. On the other hand, it provides a rational explanation as to how ZIF-8 neatly dissolves <i>in vivo</i>. </p>

Smart metal organic frameworks: Focus on cancer treatment

2021 ◽  
Author(s):  
Monir Falsafi ◽  
Amir Shokooh Saljooghi ◽  
Khalil Abnous ◽  
Seyed Mohammad Taghdisi ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Porous Materials ◽  
Metal Clusters ◽  
Metal Organic Frameworks ◽  
Controlled Systems ◽  
Metal Organic

Metal–organic frameworks (MOFs), as a prominent category of hybrid porous materials constructed from metal clusters or ions plus organic linkers, have been broadly employed as controlled systems of drug delivery...

scholarly journals Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (73) ◽  
pp. 45130-45138
Author(s):  
Li Li ◽  
Shasha Han ◽  
Sengqun Zhao ◽  
Xurui Li ◽  
Bingmi Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Metal Organic Frameworks ◽  
Oral Drug ◽  
Metal Organic

The drug delivery system of CS-MOF@5-FU was developed to achieve oral administration of 5-FU.

Lawsone Derived Zn (II) and Fe (III) Metal Organic Frameworks with pH Dependent Emission for Controlled Drug Delivery

2021 ◽  
Author(s):  
Sirajunnisa P ◽  
Liz Hannah George ◽  
Narayanapillai Manoj ◽  
Prathapan S ◽  
G.S. Sailaja
Keyword(s):  
Drug Delivery ◽  
Porous Structure ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Controlled Drug Delivery ◽  
Sensing Applications ◽  
Porous Carriers ◽  
Metal Organic ◽  
Ph Dependent

Fluorescent biocompatible porous carriers have been investigated as suitable probes for drug delivery and sensing applications owing to their intrinsic fluorescence and high surface area originating from their porous structure...

scholarly journals Recent Bio-Advances in Metal-Organic Frameworks

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1291 ◽  
Author(s):  
Isobel Tibbetts ◽  
George Kostakis
Keyword(s):  
Drug Delivery ◽  
Inorganic Material ◽  
Metal Organic Frameworks ◽  
Gas Storage ◽  
Industrial Applications ◽  
Biologically Relevant ◽  
Bioinspired Materials ◽  
Synthesis Properties ◽  
Metal Organic

Metal-organic frameworks (MOFs) have found uses in adsorption, catalysis, gas storage and other industrial applications. Metal Biomolecule Frameworks (bioMOFs) represent an overlap between inorganic, material and medicinal sciences, utilising the porous frameworks for biologically relevant purposes. This review details advances in bioMOFs, looking at the synthesis, properties and applications of both bioinspired materials and MOFs used for bioapplications, such as drug delivery, imaging and catalysis, with a focus on examples from the last five years.

scholarly journals A novel route to size-controlled MIL-53(Fe) metal–organic frameworks for combined chemodynamic therapy and chemotherapy for cancer

RSC Advances ◽  
2021 ◽  
Vol 11 (18) ◽  
pp. 10540-10547
Author(s):  
Anxia Li ◽  
Xiaoxin Yang ◽  
Juan Chen
Keyword(s):  
Drug Delivery ◽  
Therapeutic Approach ◽  
Metal Organic Frameworks ◽  
Ionic Surfactant ◽  
Controlled Synthesis ◽  
New Approach ◽  
Metal Organic ◽  
Size Controlled

In this study, we reported a new approach for the size-controlled synthesis of uniform iron(iii)-based MIL-53 nanocrystals using the non-ionic surfactant PVP. A combinational therapeutic approach was presented for drug delivery and ROS therapy.

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