Metal‐organic frameworks‐based fluorescent nanocomposites for bioimaging in living cells and in vivo

2020 ◽  
Author(s):  
Meijia Liu ◽  
Xiangling Ren ◽  
Xianwei Meng ◽  
Hongbo Li
Keyword(s):  
Metal Organic Frameworks ◽  
Living Cells ◽  
Metal Organic

In depth analysis of the in vivo toxicity of nanoparticles of porous iron(iii) metal–organic frameworks

2013 ◽  
Vol 4 (4) ◽  
pp. 1597 ◽  
Author(s):  
Tarek Baati ◽  
Leila Njim ◽  
Fadoua Neffati ◽  
Abdelhamid Kerkeni ◽  
Muriel Bouttemi ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Porous Iron ◽  
In Vivo Toxicity ◽  
Depth Analysis ◽  
Metal Organic

scholarly journals A Simple in vivo Assay Using Amphipods for the Evaluation of Potential Biocompatible Metal-Organic Frameworks

2021 ◽  
Vol 9 ◽  
Author(s):  
Ines Sifaoui ◽  
Idaira Pacheco-Fernández ◽  
José E. Piñero ◽  
Verónica Pino ◽  
Jacob Lorenzo-Morales
Keyword(s):  
Ex Vivo ◽  
Colorimetric Assay ◽  
Metal Organic Frameworks ◽  
Screening Method ◽  
Toxicity Tests ◽  
Toxicity Screening ◽  
Metal Organic ◽  
Potential Use

In this study, the application of amphipods in vivo assays was evaluated. The main aim of this work was to check the potential use of this model in biocompatibility assessments of metal-organic frameworks (MOFs). Hence, six different MOFs were synthesized and the in vitro and ex vivo cytotoxicity was first assessed using a colorimetric assay and a macrophage cell line. Obtained results were compared to validate the in vivo toxicity tests carried out using amphipods and increasing concentrations of the different MOFs. Amphipods do not require the need of ethics approval and also are less expensive to keep than conventional in vivo models, showing its potential as a fast and reliable platform in toxicity studies. The obtained results showed that the amphipods based-assay was simple, easy to replicate and yielded toxicity data corresponding to the type of MOFs tested. In addition, it was observed that only CIM-80(Al) and CIM-84(Zr) did not show any toxicity to the animals at the different tested concentrations. Therefore, the developed in vivo model could be applied as a high-throughput toxicity screening method to evaluate the toxicity of numerous materials, chemicals and therapeutic agents among others.

Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

2018 ◽  
Vol 30 (37) ◽  
pp. 1707365 ◽  
Author(s):  
Teresa Simon-Yarza ◽  
Angelika Mielcarek ◽  
Patrick Couvreur ◽  
Christian Serre
Keyword(s):  
Metal Organic Frameworks ◽  
In Vivo Efficacy ◽  
The Road ◽  
Metal Organic ◽  
On The Road

scholarly journals Packaging and delivering enzymes by amorphous metal-organic frameworks

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiaoling Wu ◽  
Hua Yue ◽  
Yuanyu Zhang ◽  
Xiaoyong Gao ◽  
Xiaoyang Li ◽  
...  
Keyword(s):  
Electron Tomography ◽  
Single Cells ◽  
Metal Organic Frameworks ◽  
Enzymatic Catalysis ◽  
Living Cells ◽  
Amorphous Metal ◽  
Precipitation Process ◽  
Ambient Conditions ◽  
One Pot ◽  
Metal Organic

AbstractEnzymatic catalysis in living cells enables the in-situ detection of cellular metabolites in single cells, which could contribute to early diagnosis of diseases. In this study, enzyme is packaged in amorphous metal-organic frameworks (MOFs) via a one-pot co-precipitation process under ambient conditions, exhibiting 5–20 times higher apparent activity than when the enzyme is encapsulated in corresponding crystalline MOFs. Molecular simulation and cryo-electron tomography (Cryo-ET) combined with other techniques demonstrate that the mesopores generated in this disordered and fuzzy structure endow the packaged enzyme with high enzyme activity. The highly active glucose oxidase delivered by the amorphous MOF nanoparticles allows the noninvasive and facile measurement of glucose in single living cells, which can be used to distinguish between cancerous and normal cells.

Highly Stable and Long‐Circulating Metal‐Organic Frameworks Nanoprobes for Sensitive Tumor Detection In Vivo

2019 ◽  
Vol 8 (19) ◽  
pp. 1900761 ◽  
Author(s):  
Ruili Zhang ◽  
Chaoqiang Qiao ◽  
Qian Jia ◽  
Yongdong Wang ◽  
Huimin Huang ◽  
...  
Keyword(s):  
Metal Organic Frameworks ◽  
Tumor Detection ◽  
Metal Organic
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