Phospholipid-based multifunctional coating via layer-by-layer self-assembly for biomedical applications

2020 ◽  
Vol 116 ◽  
pp. 111237 ◽  
Author(s):  
Peichuang Li ◽  
Xiaojing Li ◽  
Wanhao Cai ◽  
Huiqing Chen ◽  
Hang Chen ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Layer By Layer

scholarly journals Layer-by-Layer Self-Assembly Composite Coatings for Improved Corrosion and Wear Resistance of Mg Alloy for Biomedical Applications

Coatings ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 515
Author(s):  
Tongfang Liu ◽  
Song Rui ◽  
Sheng Li
Keyword(s):  
Wear Resistance ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Composite Coatings ◽  
Covalent Bond ◽  
Mg Alloys ◽  
Mg Alloy ◽  
Layer By Layer ◽  
Corrosion Propagation ◽  
Chemical Linkage

Mg alloys are promising biomedical metal due to their natural degradability, good processability, and favorable mechanical properties. However, the poor corrosion resistance limits their further clinical applications. In this study, the combined strategies of surface chemical treatment and layer-by-layer self-assembly were used to prepare composite coatings on Mg alloys to improve the biocorrosion resistance. Specially, alkalized AZ91 Mg alloy generated chemical linkage with silane via Si–O–Mg covalent bond at the interface. Subsequently, Si–OH group from silane formed a crosslinked silane layer by Si–O–Si network. Further chemical assembly with graphene oxide (GO), lengthened the diffusion pathway of corrosive medium. The chemically assembled composite coatings could firmly bond to Mg alloy substrate, which persistently and effectively acted as compact barriers against corrosion propagation. Improved biocorrosion resistance of AZ91 Mg alloy with self-assembly composite coatings of silane/GO was subsequently confirmed by immersion tests. Besides, the Mg alloy exhibited good wear resistance due to outside layer of GO with a lubricant effect. Cell viability of higher than 75% had also been found for the alloy with self-assembly composite coatings, which showed good cytocompatibility.

scholarly journals Synthesis and characterization of innovative poly(lactide-co-glycolide)-(poly-l-ornithine/fucoidan) core–shell nanocarriers by layer-by-layer self-assembly

RSC Advances ◽  
2017 ◽  
Vol 7 (52) ◽  
pp. 32786-32794 ◽  
Author(s):  
Jingqian Fan ◽  
Yuangang Liu ◽  
Shibin Wang ◽  
Yulu Liu ◽  
Siming Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Synthesis And Characterization ◽  
Core Shell ◽  
Layer By Layer

Layer-by-Layer (LbL) self-assembly of nanocarriers has garnered the interest of researchers for a wide variety of biomedical applications.

Biomedical Applications of Layer-by-Layer Self-Assembly for Cell Encapsulation: Current Status and Future Perspectives

2018 ◽  
Vol 8 (1) ◽  
pp. 1800939 ◽  
Author(s):  
Tengfei Liu ◽  
Ying Wang ◽  
Wen Zhong ◽  
Bingyun Li ◽  
Kibret Mequanint ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Cell Encapsulation ◽  
Current Status ◽  
Layer By Layer ◽  
Future Perspectives

Self-Assembly Technique for Biomedical Applications

Nano LIFE ◽  
2015 ◽  
Vol 05 (02) ◽  
pp. 1542002 ◽  
Author(s):  
Xiao Gong
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Layer By Layer ◽  
Biomedical Materials ◽  
Biomedical Material ◽  
Potential Applications ◽  
Assembly Technique

Layer-by-layer (LbL) self-assembly has attracted extensive attention for its simplicity and versatility. Self-assembly has many potential applications, among which biomedical applications is especially important because it can be used as a means of generating drug delivery and biomedical materials. Based on this, most recent progress in the field of self-assembly technique for drug delivery and biomedical material applications are summarized in this mini review. The remaining challenges are also mentioned.

scholarly journals Construction of Chitosan/Alginate Nano-Drug Delivery System for Improving Dextran Sodium Sulfate-Induced Colitis in Mice

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1884
Author(s):  
Mengfei Jin ◽  
Shangyong Li ◽  
Yanhong Wu ◽  
Dandan Li ◽  
Yantao Han
Keyword(s):  
Self Assembly ◽  
Average Diameter ◽  
Mucosal Healing ◽  
Plga Nanoparticles ◽  
Narrow Particle Size Distribution ◽  
Layer By Layer ◽  
Systemic Side Effects ◽  
Assembly Technology ◽  
The Fourier Transform ◽  
Polyelectrolyte Film

(1) Background: In the treatment of ulcerative colitis (UC), accurate delivery and release of anti-inflammatory drugs to the site of inflammation can reduce systemic side effects. (2) Methods: We took advantage of this goal to prepare resveratrol-loaded PLGA nanoparticles (RES-PCAC-NPs) by emulsification solvent volatilization. After layer-by-layer self-assembly technology, we deposited chitosan and alginate to form a three-layer polyelectrolyte film. (3) Results: It can transport nanoparticles through the gastric environment to target inflammation sites and slowly release drugs at a specific pH. The resulting RES-PCAC-NPs have an ideal average diameter (~255 nm), a narrow particle size distribution and a positively charged surface charge (~13.5 mV). The Fourier transform infrared spectroscopy showed that resveratrol was successfully encapsulated into PCAC nanoparticles, and the encapsulation efficiency reached 87.26%. In addition, fluorescence imaging showed that RES-PCAC-NPs with positive charges on the surface can effectively target and accumulate in the inflammation site while continuing to penetrate downward to promote mucosal healing. Importantly, oral RES-PCAC-NPs treatment in DSS-induced mice was superior to other results in significantly improved inflammatory markers of UC. (4) Conclusions: Our results strongly prove that RES-PCAC-NPs can target the inflamed colon for maximum efficacy, and this oral pharmaceutical formulation can represent a promising formulation in the treatment of UC.

scholarly journals The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

2021 ◽  
Author(s):  
Marissa Morales-Moctezuma ◽  
Sebastian G Spain
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Biomedical Applications

Nanogels have emerged as innovative platforms for numerous biomedical applications including gene and drug delivery, biosensors, imaging, and tissue engineering. Polymerisation-induced thermal self-assembly (PITSA) has been shown to be suitable...

Graphene-Based Multilayers Constructed from Layer-by-Layer Self-Assembly Techniques

2014 ◽  
Vol 14 (2) ◽  
pp. 1145-1153 ◽  
Author(s):  
Bing Yu ◽  
Xiaomian Liu ◽  
Hailin Cong ◽  
Hua Yuan ◽  
Dong Wang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Layer By Layer
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