Versatile Polymer Nanoparticles as Two‐Photon‐Triggered Photosensitizers for Simultaneous Cellular, Deep‐Tissue Imaging, and Photodynamic Therapy

2017 ◽  
Vol 6 (12) ◽  
pp. 1601431 ◽  
Author(s):  
Liang Guo ◽  
Jiechao Ge ◽  
Qian Liu ◽  
Qingyan Jia ◽  
Hongyan Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Polymer Nanoparticles ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Two Photon ◽  
Deep Tissue Imaging

Lysosome-targetable polythiophene nanoparticles for two-photon excitation photodynamic therapy and deep tissue imaging

2017 ◽  
Vol 5 (20) ◽  
pp. 3651-3657 ◽  
Author(s):  
Shaojing Zhao ◽  
Guangle Niu ◽  
Feng Wu ◽  
Li Yan ◽  
Hongyan Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Fluorescence Imaging ◽  
Cross Section ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Two Photon ◽  
Photon Excitation ◽  
Deep Tissue Imaging ◽  
Two Photon Excitation

Polythiophene nanoparticles with large TPA cross section and high1O2generation quantum yield have been developed for simultaneous lysosome-targetable fluorescence imaging and photodynamic therapy.

scholarly journals Red-emissive azabenzanthrone derivatives for photodynamic therapy irradiated with ultralow light power density and two-photon imaging

2018 ◽  
Vol 9 (23) ◽  
pp. 5165-5171 ◽  
Author(s):  
Qiguang Zang ◽  
Jiayi Yu ◽  
Wenbin Yu ◽  
Jun Qian ◽  
Rongrong Hu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Power Density ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Light Power ◽  
Two Photon ◽  
Deep Tissue Imaging ◽  
Photon Imaging ◽  
Two Photon Imaging

Azabenzanthrone derivatives with high phototoxicity and efficient emission are designed for photodynamic therapy and deep-tissue imaging.

scholarly journals Ultrabright red AIEgens for two-photon vascular imaging with high resolution and deep penetration

2018 ◽  
Vol 9 (10) ◽  
pp. 2705-2710 ◽  
Author(s):  
Wei Qin ◽  
Pengfei Zhang ◽  
Hui Li ◽  
Jacky W. Y. Lam ◽  
Yuanjing Cai ◽  
...  
Keyword(s):  
High Resolution ◽  
Vascular Imaging ◽  
Tissue Imaging ◽  
Deep Penetration ◽  
High Contrast ◽  
Deep Tissue ◽  
Two Photon ◽  
High Penetration ◽  
Deep Tissue Imaging

A successful strategy for the design of ultrabright red luminogens with aggregation-induced emission (AIE) features is reported. The AIE dots can be utilized as efficient fluorescent probes for in vivo deep-tissue imaging with high penetration depth and high contrast.

scholarly journals Extremely High Brightness from Polymer-Encapsulated Quantum Dots for Two-photon Cellular and Deep-tissue Imaging

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Yanyan Fan ◽  
Helin Liu ◽  
Rongcheng Han ◽  
Lu Huang ◽  
Hao Shi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
High Brightness ◽  
Two Photon ◽  
Deep Tissue Imaging

scholarly journals Multifunctional AIE Iridium (III) Photosensitizer Nanoparticles for Two-Photon-Activated Imaging and Mitochondria Targeting  Photodynamic Therapy

2021 ◽  
Author(s):  
Xuzi Cai ◽  
Kangnan Wang ◽  
Wen Ma ◽  
yuanyuan Yang ◽  
Gui Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Solubility ◽  
Redox Homeostasis ◽  
Tissue Imaging ◽  
Ros Generation ◽  
Generation Efficiency ◽  
Deep Tissue ◽  
Two Photon ◽  
Targeting Ability

Abstract Developing novel photosensitizers for deep tissue imaging and efficient photodynamic therapy (PDT) remains a challengebecause of the poor water solubility, low reactive oxygen species (ROS) generation efficiency, serve dark cytotoxicity, and weak absorption in the NIR region of conventional photosensitizers. Herein,cyclometalated iridium (III) complexes(Ir)with aggregation-induced emission (AIE) feature, high photoinduced ROS generation efficiency, two-photonexcitation, and mitochondria-targetingcapability were designed and further encapsulated into biocompatible nanoparticles (NPs).The Ir-NPs can be used to disturb redox homeostasis in vitro, result in mitochondrial dysfunction and cell apoptosis. Importantly, invivo experiments demonstrated that theIr-NPs presented obviously tumor-targeting ability, excellent antitumor effect, and low systematic dark-toxicity. Moreover, the Ir-NPs could serve as a two-photon imaging agent for deep tissue bioimaging with a penetration depth of up to 300 μm. This work presents a promising strategy for designing a clinical application of multifunctional Ir-NPs toward bioimaging and PDT.

Water-Soluble Red-Fluorescent Dyes for Two-Photon Deep-Tissue Imaging

2020 ◽  
Vol 93 (10) ◽  
pp. 1226-1233
Author(s):  
Shozo Onishi ◽  
Yasutaka Suzuki ◽  
Hikari Ano ◽  
Jun Kawamata
Keyword(s):  
Fluorescent Dyes ◽  
Water Soluble ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Two Photon ◽  
Deep Tissue Imaging

scholarly journals Addressing the autofluorescence issue in deep tissue imaging by two-photon microscopy: the significance of far-red emitting dyes

2017 ◽  
Vol 8 (11) ◽  
pp. 7696-7704 ◽  
Author(s):  
Yong Woong Jun ◽  
Hye Rim Kim ◽  
Ye Jin Reo ◽  
Mingchong Dai ◽  
Kyo Han Ahn
Keyword(s):  
Wavelength Region ◽  
Water Soluble ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Two Photon Microscopy ◽  
New Class ◽  
Two Photon ◽  
Deep Tissue Imaging

We have developed a new class of two-photon absorbing dyes that are far-red emitting, water-soluble, and very bright inside cells as well as in tissue. The significant autofluorescence from yellow wavelength region in tissue imaging can be addressed by deep-red emitting dyes.

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