Lysosome-targetable polythiophene nanoparticles for two-photon excitation photodynamic therapy and deep tissue imaging

2017 ◽  
Vol 5 (20) ◽  
pp. 3651-3657 ◽  
Author(s):  
Shaojing Zhao ◽  
Guangle Niu ◽  
Feng Wu ◽  
Li Yan ◽  
Hongyan Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Fluorescence Imaging ◽  
Cross Section ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Two Photon ◽  
Photon Excitation ◽  
Deep Tissue Imaging ◽  
Two Photon Excitation

Polythiophene nanoparticles with large TPA cross section and high1O2generation quantum yield have been developed for simultaneous lysosome-targetable fluorescence imaging and photodynamic therapy.

scholarly journals Two-Photon–NIR-II Antimicrobial Graphene-Nanoagent for Ultraviolet–NIR Imaging and Photoinactivation

2021 ◽  
Author(s):  
WEN-SHUO KUO ◽  
Chia-Yuan Chang ◽  
Ping-Ching Wu ◽  
Jiu-Yao Wang
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Chemical Modification ◽  
Near Infrared ◽  
Photon Absorption ◽  
Excitation Wavelength ◽  
Strong Electron ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Abstract BackgroundNitrogen doping and amino-group functionalization, which result in strong electron donation, can be achieved through chemical modification. Large π-conjugated systems of graphene quantum dot (GQD)-based materials acting as electron donors can be chemically manipulated with low two-photon excitation energy in a short photoexcitation time for improving the charge transfer efficiency of sorted nitrogen-doped amino acid–functionalized GQDs (sorted amino-N-GQDs). ResultsIn this study, a self-developed femtosecond Ti-sapphire laser optical system (222.7 nJ pixel−1 with 100-170 scans, approximately 0.65-1.11 s of total effective exposure times; excitation wavelength: 960 nm in the near-infrared II region) was used for chemical modification. The sorted amino-N-GQDs exhibited enhanced two-photon absorption, post-two-photon excitation stability, two-photon excitation cross-section, and two-photon luminescence through the radiative pathway. The lifetime and quantum yield of the sorted amino-N-GQDs decreased and increased, respectively. Furthermore, the sorted amino-N-GQDs exhibited excitation-wavelength-independent photoluminescence in the near-infrared region and generated reactive oxygen species after two-photon excitation. An increase in the size of the sorted amino-N-GQDs boosted photochemical and electrochemical efficacy and resulted in high photoluminescence quantum yield and highly efficient two-photon photodynamic therapy. ConclusionThe sorted dots can be used in two-photon contrast probes for tracking and localizing analytes during two-photon imaging in a biological environment and for conducting two-photon photodynamic therapy for eliminating infectious microbes.

scholarly journals Red-emissive azabenzanthrone derivatives for photodynamic therapy irradiated with ultralow light power density and two-photon imaging

2018 ◽  
Vol 9 (23) ◽  
pp. 5165-5171 ◽  
Author(s):  
Qiguang Zang ◽  
Jiayi Yu ◽  
Wenbin Yu ◽  
Jun Qian ◽  
Rongrong Hu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Power Density ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Light Power ◽  
Two Photon ◽  
Deep Tissue Imaging ◽  
Photon Imaging ◽  
Two Photon Imaging

Azabenzanthrone derivatives with high phototoxicity and efficient emission are designed for photodynamic therapy and deep-tissue imaging.

Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

2017 ◽  
Vol 9 (17) ◽  
pp. 14590-14595 ◽  
Author(s):  
Minhuan Lan ◽  
Shaojing Zhao ◽  
Yusheng Xie ◽  
Junfang Zhao ◽  
Liang Guo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Water Soluble ◽  
Two Photon ◽  
Photon Excitation ◽  
Photodynamic Therapy Of Cancer ◽  
Two Photon Excitation

scholarly journals Breaking the 1,2-HOPO barrier with a cyclen backbone for more efficient sensitization of Eu(iii) luminescence and unprecedented two-photon excitation properties

2019 ◽  
Vol 10 (17) ◽  
pp. 4550-4559 ◽  
Author(s):  
Lixiong Dai ◽  
Wai-Sum Lo ◽  
Yanjuan Gu ◽  
Qingwu Xiong ◽  
Ka-Leung Wong ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Breaking the barrier of 1,2 HOPO complexes with extremely emissive Eu-Cy-HOPO (overall quantum yield −30.2%) that displays two photon properties.

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