Drug Delivery: Targeted and pH-Responsive Delivery of Doxorubicin to Cancer Cells Using Multifunctional Dendrimer-Modified Multi-Walled Carbon Nanotubes (Adv. Healthcare Mater. 9/2013)

2013 ◽  
Vol 2 (9) ◽  
pp. 1181-1181 ◽  
Author(s):  
Shihui Wen ◽  
Hui Liu ◽  
Hongdong Cai ◽  
Mingwu Shen ◽  
Xiangyang Shi
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Ph Responsive ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

pH Responsive Release of Doxorubicin to the Cancer Cells by Functionalized Multi-Walled Carbon Nanotubes

2015 ◽  
Vol 15 (7) ◽  
pp. 4799-4805 ◽  
Author(s):  
B. Anbarasan ◽  
S. Vignesh Babu ◽  
K. Elango ◽  
B. Shriya ◽  
S. Ramaprabhu
Keyword(s):  
Carbon Nanotubes ◽  
Cancer Cells ◽  
Ph Responsive ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy

2017 ◽  
Vol 8 (45) ◽  
pp. 6938-6942 ◽  
Author(s):  
Daquan Wang ◽  
Yibo Ren ◽  
Yongping Shao ◽  
Lingjie Meng
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Photothermal Therapy ◽  
Normal Cells ◽  
Redox Responsive ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

A multifunctional drug delivery system for chemo-photothermal therapeutics was developed by coating an anticancer-drug-containing polyphosphazene onto multi-walled carbon nanotubes, which could selectively suppress and kill cancer cells, but negligibly affect normal cells.

scholarly journals Multi-Walled Carbon Nanotubes Decorated with Guanidinylated Dendritic Molecular Transporters: An Efficient Platform for the Selective Anticancer Activity of Doxorubicin

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 858
Author(s):  
Kyriaki-Marina Lyra ◽  
Archontia Kaminari ◽  
Katerina N. Panagiotaki ◽  
Konstantinos Spyrou ◽  
Sergios Papageorgiou ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Delivery System ◽  
Colloidal Stability ◽  
Triggered Release ◽  
Selective Toxicity ◽  
Molecular Transporters ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

An efficient doxorubicin (DOX) drug delivery system with specificity against tumor cells was developed, based on multi-walled carbon nanotubes (MWCNTs) functionalized with guanidinylated dendritic molecular transporters. Acid-treated MWCNTs (oxCNTs) interacted both electrostatically and through hydrogen bonding and van der Waals attraction forces with guanidinylated derivatives of 5000 and 25,000 Da molecular weight hyperbranched polyethyleneimine (GPEI5K and GPEI25K). Chemical characterization of these GPEI-functionalized oxCNTs revealed successful decoration with GPEIs all over the oxCNTs sidewalls, which, due to the presence of guanidinium groups, gave them aqueous compatibility and, thus, exceptional colloidal stability. These GPEI-functionalized CNTs were subsequently loaded with DOX for selective anticancer activity, yielding systems of high DOX loading, up to 99.5% encapsulation efficiency, while the DOX-loaded systems exhibited pH-triggered release and higher therapeutic efficacy compared to that of free DOX. Most importantly, the oxCNTs@GPEI5K-DOX system caused high and selective toxicity against cancer cells in a non-apoptotic, fast and catastrophic manner that cancer cells cannot recover from. Therefore, the oxCNTs@GPEI5K nanocarrier was found to be a potent and efficient nanoscale DOX delivery system, exhibiting high selectivity against cancerous cells, thus constituting a promising candidate for cancer therapy.

pH-Switchable electroactive composite films of carboxylated multi-walled carbon nanotubes and Prussian blue

RSC Advances ◽  
2015 ◽  
Vol 5 (125) ◽  
pp. 103184-103188
Author(s):  
Ying Tong ◽  
Yuanyuan Wang ◽  
Bowen Gao ◽  
Lei Su ◽  
Xueji Zhang
Keyword(s):  
Thin Films ◽  
Carbon Nanotubes ◽  
Prussian Blue ◽  
Composite Films ◽  
Ph Responsive ◽  
Composite Thin Films ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Here the combination of carboxylated multi-walled carbon nanotubes (CMWCNTs) and Prussian blue (PB) for fabricating pH-responsive electroactive composite thin films is reported.

The “click-on-tube” approach for the production of efficient drug carriers based on oxidized multi-walled carbon nanotubes

2016 ◽  
Vol 4 (21) ◽  
pp. 3823-3831 ◽  
Author(s):  
Stefano Fedeli ◽  
Alberto Brandi ◽  
Lorenzo Venturini ◽  
Paola Chiarugi ◽  
Elisa Giannoni ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carriers ◽  
Multi Walled Carbon Nanotube ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Straightforward Approach

An efficient drug delivery system through a straightforward approach to multi-walled carbon nanotube decoration.

Nanohybrid Nanoparticles Based on Chitosan/Functionalized Carbon Nanotubes as Anti-HIV Nanocarrier

NANO ◽  
2015 ◽  
Vol 10 (01) ◽  
pp. 1550010 ◽  
Author(s):  
R. Afshari ◽  
S. Mazinani ◽  
M. Abdouss
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Carbon Nanotube ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Delivery Systems ◽  
Potential Applications ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Carbon nanotube-natural biopolymer nanovectors have important potential applications in delivery system for drugs and biomolecules. In this work, the use of multi-walled carbon nanotubes (MWCNT) as nanoreservoirs for drug loading and controlled release is demonstrated. We synthesized different carbon nanotube-based drug delivery systems including acid and amide-functionalized MWCNT; chitosan (CS) covalently grafted to functionalized MWCNT and MWCNT-CS nanoparticles (NPs) using an ionotropic gelation method as a sustained-release systems for delivery of Tenofovir (hydrophilic anti-retroviral drug). The prepared NPs as different drug delivery systems were characterized by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). As it is shown, in vitro drug release studies indicated that the cumulative release rate of Tenofovir from MWCNT–CS NPs shows the best result and it reaches the maximum value (90%) after about 120 h. Moreover, comparing to ungrafted CNTs, MWCNT–CS shows high dispersability and long-term stability in aqueous medium which approves the effective solubilization of MWCNT followed by grafting with CS.

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