Targeted and pH-Responsive Delivery of Doxorubicin to Cancer Cells Using Multifunctional Dendrimer-Modified Multi-Walled Carbon Nanotubes

2013 ◽  
Vol 2 (9) ◽  
pp. 1267-1276 ◽  
Author(s):  
Shihui Wen ◽  
Hui Liu ◽  
Hongdong Cai ◽  
Mingwu Shen ◽  
Xiangyang Shi
Keyword(s):  
Carbon Nanotubes ◽  
Cancer Cells ◽  
Ph Responsive ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

pH Responsive Release of Doxorubicin to the Cancer Cells by Functionalized Multi-Walled Carbon Nanotubes

2015 ◽  
Vol 15 (7) ◽  
pp. 4799-4805 ◽  
Author(s):  
B. Anbarasan ◽  
S. Vignesh Babu ◽  
K. Elango ◽  
B. Shriya ◽  
S. Ramaprabhu
Keyword(s):  
Carbon Nanotubes ◽  
Cancer Cells ◽  
Ph Responsive ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

scholarly journals Multi-Walled Carbon Nanotubes Decorated with Guanidinylated Dendritic Molecular Transporters: An Efficient Platform for the Selective Anticancer Activity of Doxorubicin

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 858
Author(s):  
Kyriaki-Marina Lyra ◽  
Archontia Kaminari ◽  
Katerina N. Panagiotaki ◽  
Konstantinos Spyrou ◽  
Sergios Papageorgiou ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Delivery System ◽  
Colloidal Stability ◽  
Triggered Release ◽  
Selective Toxicity ◽  
Molecular Transporters ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

An efficient doxorubicin (DOX) drug delivery system with specificity against tumor cells was developed, based on multi-walled carbon nanotubes (MWCNTs) functionalized with guanidinylated dendritic molecular transporters. Acid-treated MWCNTs (oxCNTs) interacted both electrostatically and through hydrogen bonding and van der Waals attraction forces with guanidinylated derivatives of 5000 and 25,000 Da molecular weight hyperbranched polyethyleneimine (GPEI5K and GPEI25K). Chemical characterization of these GPEI-functionalized oxCNTs revealed successful decoration with GPEIs all over the oxCNTs sidewalls, which, due to the presence of guanidinium groups, gave them aqueous compatibility and, thus, exceptional colloidal stability. These GPEI-functionalized CNTs were subsequently loaded with DOX for selective anticancer activity, yielding systems of high DOX loading, up to 99.5% encapsulation efficiency, while the DOX-loaded systems exhibited pH-triggered release and higher therapeutic efficacy compared to that of free DOX. Most importantly, the oxCNTs@GPEI5K-DOX system caused high and selective toxicity against cancer cells in a non-apoptotic, fast and catastrophic manner that cancer cells cannot recover from. Therefore, the oxCNTs@GPEI5K nanocarrier was found to be a potent and efficient nanoscale DOX delivery system, exhibiting high selectivity against cancerous cells, thus constituting a promising candidate for cancer therapy.

pH-Switchable electroactive composite films of carboxylated multi-walled carbon nanotubes and Prussian blue

RSC Advances ◽  
2015 ◽  
Vol 5 (125) ◽  
pp. 103184-103188
Author(s):  
Ying Tong ◽  
Yuanyuan Wang ◽  
Bowen Gao ◽  
Lei Su ◽  
Xueji Zhang
Keyword(s):  
Thin Films ◽  
Carbon Nanotubes ◽  
Prussian Blue ◽  
Composite Films ◽  
Ph Responsive ◽  
Composite Thin Films ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Here the combination of carboxylated multi-walled carbon nanotubes (CMWCNTs) and Prussian blue (PB) for fabricating pH-responsive electroactive composite thin films is reported.

scholarly journals Combining Carbon Nanotubes and Chitosan for the Vectorization of Methotrexate to Lung Cancer Cells

Materials ◽  
2019 ◽  
Vol 12 (18) ◽  
pp. 2889 ◽  
Author(s):  
Giuseppe Cirillo ◽  
Orazio Vittorio ◽  
David Kunhardt ◽  
Emanuele Valli ◽  
Florida Voli ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Carbon Nanotubes ◽  
Photoelectron Spectroscopy ◽  
Ph Responsive ◽  
Carbon Nanostructure ◽  
X Ray ◽  
Transmission Electron ◽  
Multi Walled Carbon Nanotubes ◽  
Responsive Behavior ◽  
Walled Carbon Nanotubes

A hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1s signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299.

Adsorption, and controlled release of doxorubicin from cellulose acetate/polyurethane/multi-walled carbon nanotubes composite nanofibers

2021 ◽  
Author(s):  
Reza Alisani ◽  
Navid Rakhshani ◽  
maryam Abolhallaj ◽  
Foojan Motevallid ◽  
Parvaneh Ghaderi-shekhi Abadi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Carbon Nanotubes ◽  
Cancer Cells ◽  
Cellulose Acetate ◽  
Composite Nanofibers ◽  
Prostate Cancer Cells ◽  
Environmental Application ◽  
The Status ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Abstract The cellulose acetate (CA)/poly (ε-caprolactone diol)/poly (tetramethylene ether) glycol-polyurethane (PCL-Diol/PTMG-PU)/multi-walled carbon nanotubes (MWCNTs) composite nanofibers were prepared via two-nozzle electrospinning on both counter sides of the collector. The performance of synthesized composite nanofibers was investigated as an environmental application and anticancer delivery system for the adsorption/release of doxorubicin (DOX). The synergic effect of MWCNTs and DOX incorporated into the nanofibers was investigated against LNCaP prostate cancer cells. The status of MWCNTs and DOX in composite nanofibers was demonstrated by SEM, FTIR and UV-Vis determinations. The adsorption tests using nanofibrous adsorbent toward DOX sorption was evaluated under various DOX initial concentrations (100-2000 mgL-1 ), adsorption times (5-120 minutes), and pH values (pH:2-9). Due to the fitting of isotherm and kinetic data with Redlich-Peterson and pseudo-second order models, both chemisorption and surface adsorption of DOX molecules mechanisms have been predicted. The drug release from both nanofibers and MWCNTs-loaded nanofibers was compared. The better drug sustained release profiles verified in the presence of composite nanofibers. LNCaP prostate cancer and L929 normal cells were treated to investigate the cytotoxicity and compatibility of synthesized composite nanofibers. The apoptosis/necrosis of hybrid nanofibers and MWCNTs loaded-nanofibers was investigated. The obtained results demonstrated the synergic effects of MWCNTs and DOX loaded-nanofibers on the LNCaP prostate cancer cells death.

scholarly journals Construction of Multiple Switchable Sensors and Logic Gates Based on Carboxylated Multi-Walled Carbon Nanotubes/Poly(N,N-Diethylacrylamide)

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3358 ◽  
Author(s):  
Xuemei Wu ◽  
Xiaoqing Bai ◽  
Yang Ma ◽  
Jie Wei ◽  
Juan Peng ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Logic Gate ◽  
Logic Gates ◽  
Present System ◽  
Ph Responsive ◽  
Cyclic Voltammetric ◽  
Computing Systems ◽  
Multi Walled Carbon Nanotubes ◽  
Gate System ◽  
Walled Carbon Nanotubes

In this work, binary hydrogel films based on carboxylated multi-walled carbon nanotubes/poly(N,N-diethylacrylamide) (c-MWCNTs/PDEA) were successfully polymerized and assembled on a glassy carbon (GC) electrode surface. The electroactive drug probes matrine and sophoridine in solution showed reversible thermal-, salt-, methanol- and pH-responsive switchable cyclic voltammetric (CV) behaviors at the film electrodes. The control experiments showed that the pH-responsive property of the system could be ascribed to the drug components of the solutions, whereas the thermal-, salt- and methanol-sensitive behaviors were attributed to the PDEA constituent of the films. The CV signals particularly, of matrine and sophoridine were significantly amplified by the electrocatalysis of c-MWCNTs in the films at 1.02 V and 0.91 V, respectively. Moreover, the addition of esterase, urease, ethyl butyrate, and urea to the solution also changed the pH of the system, and produced similar CV peaks as with dilution by HCl or NaOH. Based on these experiments, a 6-input/5-output logic gate system and 2-to-1 encoder were successfully constructed. The present system may lead to the development of novel types of molecular computing systems.

scholarly journals Prostate-specific membrane antigen–directed nanoparticle targeting for extreme nearfield ablation of prostate cancer cells

Tumor Biology ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 101042831769594 ◽  
Author(s):  
Seung S Lee ◽  
Philip JR Roche ◽  
Paresa N Giannopoulos ◽  
Elliot J Mitmaker ◽  
Michael Tamilia ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Carbon Nanotubes ◽  
Cancer Cells ◽  
Tissue Damage ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Cells ◽  
Cell Ablation ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Specific Membrane

Almost all biological therapeutic interventions cannot overcome neoplastic heterogeneity. Physical ablation therapy is immune to tumor heterogeneity, but nearby tissue damage is the limiting factor in delivering lethal doses. Multi-walled carbon nanotubes offer a number of unique properties: chemical stability, photonic properties including efficient light absorption, thermal conductivity, and extensive surface area availability for covalent chemical ligation. When combined together with a targeting moiety such as an antibody or small molecule, one can deliver highly localized temperature increases and cause extensive cellular damage. We have functionalized multi-walled carbon nanotubes by conjugating an antibody against prostate-specific membrane antigen. In our in vitro studies using prostate-specific membrane antigen–positive LNCaP prostate cancer cells, we have effectively demonstrated cell ablation of >80% with a single 30-s exposure to a 2.7-W, 532-nm laser for the first time without bulk heating. We also confirmed the specificity and selectivity of prostate-specific membrane antigen targeting by assessing prostate-specific membrane antigen–null PC3 cell lines under the same conditions (<10% cell ablation). This suggests that we can achieve an extreme nearfield cell ablation effect, thus restricting potential tissue damage when transferred to in vivo clinical applications. Developing this new platform will introduce novel approaches toward current therapeutic modalities and will usher in a new age of effective cancer treatment squarely addressing tumoral heterogeneity.

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