Enzymatic Micromotors as a Mobile Photosensitizer Platform for Highly Efficient On‐Chip Targeted Antibacteria Photodynamic Therapy

2019 ◽  
Vol 29 (17) ◽  
pp. 1807727 ◽  
Author(s):  
Dandan Xu ◽  
Chao Zhou ◽  
Chen Zhan ◽  
Yong Wang ◽  
Yongqiang You ◽  
...  
2022 ◽  
Vol 27 (1) ◽  
pp. 1-31
Author(s):  
Sri Harsha Gade ◽  
Sujay Deb

Cache coherence ensures correctness of cached data in multi-core processors. Traditional implementations of existing protocols make them unscalable for many core architectures. While snoopy coherence requires unscalable ordered networks, directory coherence is weighed down by high area and energy overheads. In this work, we propose Wireless-enabled Share-aware Hybrid (WiSH) to provide scalable coherence in many core processors. WiSH implements a novel Snoopy over Directory protocol using on-chip wireless links and hierarchical, clustered Network-on-Chip to achieve low-overhead and highly efficient coherence. A local directory protocol maintains coherence within a cluster of cores, while coherence among such clusters is achieved through global snoopy protocol. The ordered network for global snooping is provided through low-latency and low-energy broadcast wireless links. The overheads are further reduced through share-aware cache segmentation to eliminate coherence for private blocks. Evaluations show that WiSH reduces traffic by and runtime by , while requiring smaller storage and lower energy as compared to existing hierarchical and hybrid coherence protocols. Owing to its modularity, WiSH provides highly efficient and scalable coherence for many core processors.


2020 ◽  
Vol 11 (9) ◽  
pp. 2494-2503 ◽  
Author(s):  
Zheng Zheng ◽  
Haixiang Liu ◽  
Shaodong Zhai ◽  
Haoke Zhang ◽  
Guogang Shan ◽  
...  

Mitochondria-targeted photosensitizers with highly efficient singlet oxygen generation, bright near-infrared AIE and good two-photon absorption are obtained through ingenious molecular engineering for cancer cell-selective photodynamic therapy.


2020 ◽  
Vol 11 (26) ◽  
pp. 6882-6888 ◽  
Author(s):  
Peng Gao ◽  
Mengzhen Wang ◽  
Yuanyuan Chen ◽  
Wei Pan ◽  
Ping Zhou ◽  
...  

A covalent organic framework-based nanoplatform has been developed for cancer imaging, photodynamic therapy, and prognosis.


2020 ◽  
Vol 44 (22) ◽  
pp. 9355-9364 ◽  
Author(s):  
Qunshou Kong ◽  
Boxuan Ma ◽  
Tao Yu ◽  
Cheng Hu ◽  
Gaocan Li ◽  
...  

Nowadays, photodynamic therapy (PDT) has become an effective method for cancer therapy.


Small ◽  
2020 ◽  
Vol 16 (23) ◽  
pp. 2001059 ◽  
Author(s):  
Dapeng Chen ◽  
Qing Yu ◽  
Xuan Huang ◽  
Hanming Dai ◽  
Tao Luo ◽  
...  

Author(s):  
Ziqi Zhang ◽  
Zhuanning Lu ◽  
Qiong Yuan ◽  
Chen Zhang ◽  
Yanli Tang

A biocompatible and ROS-responsive drug delivery nanocarrier iRGD-BDOX@CPNs with active targeting was constructed for highly efficient chemo-/photodynamic (PDT) synergistic therapy.


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