scholarly journals Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism

2018 ◽  
Vol 28 (34) ◽  
pp. 1800960 ◽  
Author(s):  
Hyun-Ouk Kim ◽  
Woonsung Na ◽  
Minjoo Yeom ◽  
Jihye Choi ◽  
Jihye Kim ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Host Cell ◽  
Rapid Detection ◽  
Cell Entry ◽  
Viral Fusion ◽  
Highly Pathogenic ◽  
Entry Mechanism

scholarly journals Infectious Cell Entry Mechanism of Influenza Virus

1982 ◽  
Vol 43 (1) ◽  
pp. 284-293 ◽  
Author(s):  
Akihiko Yoshimura ◽  
Kazumichi Kuroda ◽  
Kazunori Kawasaki ◽  
Shohei Yamashina ◽  
Toyozo Maeda ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Cell Entry ◽  
Entry Mechanism

scholarly journals Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction

2016 ◽  
Vol 91 (4) ◽  
Author(s):  
Giulia Torriani ◽  
Clara Galan-Navarro ◽  
Stefan Kunz
Keyword(s):  
Host Cell ◽  
Viral Entry ◽  
Molecular Mechanisms ◽  
Cell Interaction ◽  
Cell Entry ◽  
Lassa Virus ◽  
Human Pathogen ◽  
Highly Pathogenic ◽  
Receptor Recognition ◽  
Host Cell Interaction

ABSTRACT Viral entry represents the first step of every viral infection and is a determinant for the host range and disease potential of a virus. Here, we review the latest developments on cell entry of the highly pathogenic Old World arenavirus Lassa virus, providing novel insights into the complex virus-host cell interaction of this important human pathogen. We will cover new discoveries on the molecular mechanisms of receptor recognition, endocytosis, and the use of late endosomal entry factors.

Characterization of the host cell entry of filamentous influenza virus

2005 ◽  
Vol 150 (9) ◽  
pp. 1783-1796 ◽  
Author(s):  
S. B. Sieczkarski ◽  
G. R. Whittaker
Keyword(s):  
Influenza Virus ◽  
Host Cell ◽  
Cell Entry ◽  
Host Cell Entry

scholarly journals Cell-penetrating peptide-mediated cell entry of H5N1 highly pathogenic avian influenza virus

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Naoki Kajiwara ◽  
Namiko Nomura ◽  
Masako Ukaji ◽  
Naoki Yamamoto ◽  
Michinori Kohara ◽  
...  
Keyword(s):  
Amino Acids ◽  
Influenza Virus ◽  
Sialic Acid ◽  
Avian Influenza ◽  
Highly Pathogenic Avian Influenza ◽  
Cell Entry ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza ◽  
Cell Penetrating ◽  
Pathogenic Avian Influenza Virus

Abstract H5N1 highly pathogenic avian influenza virus (HPAIV) poses a huge threat to public health and the global economy. These viruses cause systemic infection in poultry and accidental human infection leads to severe pneumonia, associated with high mortality rates. The hemagglutinin (HA) of H5N1 HPAIV possesses multiple basic amino acids, as in the sequence RERRRKKR at the cleavage site; however, the role of this motif is not fully understood. Here, we showed that a 33-amino acid long peptide derived from HA of H5N1 HPAIV (HA314-46) has the potential to penetrate various cells and lung tissue through a sialic acid-independent endocytotic pathway. Mutant peptide analyses revealed that the cysteine residue at position 318 and multiple basic amino acids were essential for the cell-penetrating activity. Moreover, reassortant viruses possessing H5 HA could enter sialic acid-deficient cells, and virus internalisation was facilitated by cleavage with recombinant furin. Thus, our findings demonstrate that the HA314-46 motif exhibits cell-penetrating activity through a sialic acid-independent cell entry mechanism.

scholarly journals The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases

Viruses ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 837 ◽  
Author(s):  
Gonzalo Izaguirre
Keyword(s):  
Surface Proteins ◽  
Cell Entry ◽  
The Other ◽  
Highly Pathogenic ◽  
Proprotein Convertases ◽  
Enveloped Viruses ◽  
Secretion Pathway ◽  
Pathogenic Viruses ◽  
Protein Secretion Pathway ◽  
Entry Mechanism

A wide variety of viruses exploit furin and other proprotein convertases (PCs) of the constitutive protein secretion pathway in order to regulate their cell entry mechanism and infectivity. Surface proteins of enveloped, as well as non-enveloped, viruses become processed by these proteases intracellularly during morphogenesis or extracellularly after egress and during entry in order to produce mature virions activated for infection. Although viruses also take advantage of other proteases, it is when some viruses become reactive with PCs that they may develop high pathogenicity. Besides reacting with furin, some viruses may also react with the PCs of the other specificity group constituted by PC4/PC5/PACE4/PC7. The targeting of PCs for inhibition may result in a useful strategy to treat infections with some highly pathogenic viruses. A wide variety of PC inhibitors have been developed and tested for their antiviral activity in cell-based assays.

Kinetic stability modulation of polymeric nanoparticles for enhanced detection of influenza virus via penetration of viral fusion peptides

2021 ◽  
Author(s):  
Chaewon Park ◽  
Jong-Woo Lim ◽  
Geunseon Park ◽  
Hyun-Ouk Kim ◽  
Sojeong Lee ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Host Cell ◽  
Detection System ◽  
Polymeric Nanoparticles ◽  
Virus Detection ◽  
Kinetic Stability ◽  
Influenza Viruses ◽  
Viral Fusion ◽  
Fusion Peptides ◽  
Insight Into

Virus detection is materialized by engineered polymeric nanoparticles as host cell-mimetic decoys and analysis of the kinetic stability of nanoparticles against fusion peptides provides insight into the design of influenza viruses detection system.

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